唐氏筛查指标预测不良妊娠结局的研究进展
Research Progress on Down Syndrome Screening Indicators for Predicting Adverse Pregnancy Outcomes
DOI: 10.12677/jcpm.2026.51032, PDF,    科研立项经费支持
作者: 欧语波, 黄大元：吉首大学医学院，湖南 吉首；张 静*：中南大学湘雅医学院附属常德医院(常德市第一人民医院)，产科，湖南 常德
关键词: 唐氏筛查；不良妊娠结局；流产；早产；妊娠期高血压；Down’s Syndrome Screening； Adverse Pregnancy Outcomes； Abortion； Premature Delivery； Gestational Hypertension
摘要: 唐氏筛查是孕期常规检测的重要组成部分，主要通过测定母体血清中的特定标记物(如甲胎蛋白、游离β-hCG、血浆蛋白A等)来评估胎儿患有唐氏综合症的风险。近年来，研究者们逐渐认识到这些血清标记物在预测不良妊娠结局(如流产、早产、胎儿生长受限等)中的潜在价值。本文旨在综述唐氏筛查血清标记物的研究进展，探讨其在不良妊娠结局预测中的应用及其机制，为临床实践提供参考。
Abstract: Down’s syndrome screening is an important part of routine prenatal testing, mainly assessing the risk of Down’s syndrome in the fetus by measuring specific markers in the mother’s serum (such as alpha-fetoprotein, free β-hCG, and plasma protein A, etc.). In recent years, researchers have gradually recognized the potential value of these serum markers in predicting adverse pregnancy outcomes (such as miscarriage, preterm birth, and fetal growth restriction, etc.). This article aims to review the research progress of serum markers in Down’s syndrome screening, explore their application and mechanism in predicting adverse pregnancy outcomes, and provide references for clinical practice.
文章引用：欧语波, 黄大元, 张静. 唐氏筛查指标预测不良妊娠结局的研究进展[J]. 临床个性化医学, 2026, 5(1): 214-221. https://doi.org/10.12677/jcpm.2026.51032

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