基于网络药理学探究黄芪、白术治疗女性复发性尖锐湿疣的作用机制

Exploration of the Mechanism of Astragalus membranaceus and Atractylodes macrocephala in Treating Female Recurrent Condyloma Acuminatum Based on Network Pharmacology

摘要: 复发性尖锐湿疣(RCA)在女性中复发率高，除HPV持续感染外，女性经期后外环境因素及冲任不足也是重要诱因，且现有治疗多聚焦于外部疣体，对阴道内及宫颈病变关注不足。固冲汤源自《医学衷中参西录》，传统用于妇科血症，从冲任不调角度出发，现代临床显示其有免疫调节、抗病毒潜在作用。本研究基于网络药理学，聚焦固冲汤中与治疗RCA相关性较强的2~3味主要药物，即黄芪、白术，探究其治疗女性RCA的作用机制。通过网络构建与分析，筛选出活性成分及潜在靶点，确定核心靶点与关键通路，包括HPV感染、免疫调节及细胞凋亡与增殖调控相关通路。

Abstract: Recurrent condyloma acuminatum (RCA) has a high recurrence rate in women. In addition to persistent human papillomavirus (HPV) infection, external environmental factors after menstruation and insufficient Chong and Ren channels (a concept in traditional Chinese medicine related to reproductive function) are also important predisposing factors. Moreover, current treatments mostly focus on external warts, with insufficient attention given to vaginal and cervical lesions. Guchong Decoction, originating from “Medicine for Sincere and In-depth Learning of Chinese and Western Medicine”, is traditionally used for gynecological hematological diseases. From the perspective of disharmony of Chong and Ren channels, modern clinical studies show its potential immunomodulatory and antiviral effects. This study, based on network pharmacology, focuses on 2~3 main drugs in Guchong Decoction that are highly relevant to the treatment of RCA, namely Astragalus membranaceus (Huangqi) and Atractylodes macrocephala (Baizhu), to explore their mechanism of action in treating female RCA. Through network construction and analysis, active components and potential targets were screened out, and core targets and key pathways were identified, including those related to HPV infection, immune regulation, and the regulation of cell apoptosis and proliferation.