右美托咪定联合硝酸甘油控制性降压在经尿道前列腺电切术中的效果观察

Observation of the Effect of Dexmedetomidine Combined with Nitroglycerin on Controlled Hypotension in Transurethral Resection of the Prostate

摘要: 目的：探讨在经尿道前列腺电切术中通过右美托咪定联合硝酸甘油进行控制性降压的效果。方法：选取2023年1月~2025年3月在本院接受经尿道前列腺电切术的患者52例，随机分作两组，参照组26例通过硝酸甘油实施控制性降压，联合组26例通过右美托咪定联合硝酸甘油实施控制性降压，对比两组血压控制效果、手术应激反应及并发症。结果：联合组平均动脉压(MAP)、中心静脉压(CVP)均较参照组低(P < 0.05)；联合组去甲肾上腺素(NE)、多巴胺(DA)、C反应蛋白(CRP)较参照组低(P < 0.05)；联合组并发症发生率较参照组低(P < 0.05)。结论：在经尿道前列腺电切术控制性降压中，应用右美托咪定联合硝酸甘油方案可达到良好降压效果，并减轻术后应激反应，进而减少并发症。

Abstract: Objective: To explore the effect of dexmedetomidine combined with nitroglycerin on controlled hypotension during transurethral resection of the prostate. Method: 52 patients who underwent transurethral resection of the prostate in our hospital from January 2023 to March 2025 were randomly divided into two groups. The reference group (26 cases) received controlled hypotension with nitroglycerin, while the combination group (26 cases) received controlled hypotension with dexmedetomidine combined with nitroglycerin. The blood pressure control effect, surgical stress response, and complications were compared between the two groups. Results: The mean arterial pressure (MAP) and central venous pressure (CVP) in the combined group were lower than those in the control group (P < 0.05). The levels of norepinephrine (NE), dopamine (DA), and C-reactive protein (CRP) in the combined group were lower than those in the control group (P < 0.05). The complication rate in the combined group was lower than that in the control group (P < 0.05). Conclusion: In transurethral resection of the prostate, the combination of dexmedetomidine and nitroglycerin can achieve effective blood pressure control, reduce postoperative stress responses, and consequently decrease complications.