地黄治疗骨科疾病的研究进展——从分子机制到临床应用

Research Progress on the Treatment of Orthopedic Diseases with Rehmannia glutinosa—From Molecular Mechanisms to Clinical Applications

摘要: 地黄(Rehmannia glutinosa Libosch)作为传统中药，在骨科疾病治疗中具有悠久历史。本文系统综述了地黄及其活性成分在骨关节炎、骨质疏松、类风湿性关节炎等骨科疾病中的药理作用、分子机制及临床疗效。现代药理学研究表明，梓醇、地黄苷A、毛蕊花糖苷等核心成分通过调控Hsp90β、PI3K/AKT、MCP-1/CCR2等信号通路，抑制软骨细胞凋亡、促进成骨分化、调节骨代谢平衡。临床研究证实含地黄复方(如六味地黄丸、通督地黄汤)可显著改善患者骨代谢指标及临床症状。本文为地黄治疗骨科疾病的深入研究和临床应用提供理论依据。

Abstract: Rehmannia glutinosa Libosch as a traditional Chinese medicine, has a long history in the treatment of orthopedic diseases. This article systematically reviews the pharmacological effects, molecular mechanisms and clinical efficacy of Rehmannia glutinosa and its active components in orthopedic diseases such as osteoarthritis, osteoporosis, and rheumatoid arthritis. Modern pharmacological studies have shown that core components such as zeyu alcohol, Rehmannia glycoside A, and camphor sugar glycoside can regulate the Hsp90β, PI3K/AKT, MCP-1/CCR2 signaling pathways, inhibit chondrocyte apoptosis, promote osteogenic differentiation, and regulate bone metabolic balance. Clinical studies have confirmed that compound preparations containing Rehmannia glutinosa (such as Liuwei Dihuang Pills and Tongdu Dihuang Decoction) can significantly improve patients’ bone metabolic indicators and clinical symptoms. This article provides a theoretical basis for in-depth research and clinical application of Rehmannia glutinosa in the treatment of orthopedic diseases.