复方桐叶烧伤油联合重组人表皮生长因子对ICU患者失禁性皮炎的效果研究

Effect of Compound Tung Leaf Burn Oil Combined with Recombinant Human Epidermal Growth Factor on Incontinence-Associated Dermatitis in ICU Patients

摘要: 目的：失禁性皮炎(IAD)是ICU患者常见的皮肤问题，严重影响患者的舒适度和治疗效果。本研究旨在评估复方桐叶烧伤油联合重组人表皮生长因子对ICU患者失禁性皮炎的治疗效果。方法：本研究为前瞻性、随机对照临床试验。2023年10月至2024年10月期间，选取在某医院ICU住院的60例失禁性皮炎患者，按随机数字法分为干预组(30例)和对照组(30例)。干预组接受复方桐叶烧伤油联合重组人表皮生长因子的治疗，对照组接受复方桐叶烧伤油单独治疗。治疗疗程为10天，评估指标包括皮肤损伤严重程度、IAD发生率、发生时间、PAT量表评分等。结果：干预组在皮损严重程度、IAD发生率、发生时间和PAT量表评分方面均显著优于对照组(P < 0.05)。干预组皮损的重度发生率为0%，而对照组为6.67%；IAD发生率为16.67%，显著低于对照组的40.00%。干预后，干预组的PAT量表评分显著降低(3.95 ± 0.93 vs. 5.16 ± 1.66, P = 0.001)。此外，干预组患者的皮肤损伤愈合速度明显快于对照组。结论：复方桐叶烧伤油联合重组人表皮生长因子能够显著改善ICU患者失禁性皮炎的治疗效果，缩短皮损愈合时间，减少皮肤损伤的严重程度，改善患者的心理状态，具有较好的临床应用前景。

Abstract: Objective: Incontinence-associated dermatitis (IAD) is a common skin problem in ICU patients, which seriously affects the comfort and therapeutic effect of patients. The purpose of this study is to evaluate the therapeutic effect of compound tung leaf burn oil combined with recombinant human epidermal growth factor on incontinence-associated dermatitis in ICU patients. Methods: This study is a prospective, randomized controlled clinical trial. From October 2023 to October 2024, 60 patients with incontinence-associated dermatitis in ICU of a hospital were randomly divided into intervention group (30 cases) and control group (30 cases). The intervention group was treated with compound tung leaf burn oil combined with recombinant human epidermal growth factor, while the control group was treated with compound tung leaf burn oil alone. The course of treatment lasted for 10 days, and the evaluation indexes included the severity of skin injury, IAD incidence, occurrence time, PAT scale score and so on. Results: The intervention group was significantly better than the control group in the severity of skin lesions, IAD incidence, occurrence time and PAT scale score (P < 0.05). The severe incidence of skin lesions in the intervention group was 0%, while that in the control group was 6.67%. The incidence of IAD was 16.67%, which was significantly lower than that of control group (40.00%). After the intervention, the score of PAT in the intervention group decreased significantly (3.95 ± 0.93 vs. 5.16 ± 1.66, P = 0.001). In addition, the healing speed of skin injury in the intervention group was significantly faster than that in the control group. Conclusion: Compound tung leaf burn oil combined with recombinant human epidermal growth factor can significantly improve the therapeutic effect of incontinence-associated dermatitis in ICU patients, shorten the healing time of skin lesions, reduce the severity of skin injuries, and improve the psychological state of patients, which has a good clinical application prospect.