蛇床子散加减方联合CO₂点阵激光在外阴白色病变中的临床疗效观察

Clinical Observation on the Therapeutic Efficacy of Modified Shechuangzi Decoction Combined with CO₂ Fractional Laser in the Treatment of Vulvar Leukoplakia

摘要: 目的：探究蛇床子散加减方联合CO₂点阵激光在外阴白色病变中的应用效果，从而为疾病的临床治疗提供新的思路和实践借鉴。方法：选取2025年7月~2025年12月在我院收治的外阴白色病变患者50例，采用随机数字表法分研究组和对照组，对照组采取CO₂点阵激光治疗，研究组在对照组基础上采取蛇床子散加减方。统计两组治疗前后临床症状积分、炎症因子指标、生活质量、不良反应发生率等，比较两组之间差异，分析蛇床子散加减方联合CO₂点阵激光治疗外阴白色病变的临床效果。结果：治疗前后临床症状积分、炎症因子指标、生活质量、不良反应发生率等比较，研究组均优于对照组(P < 0.05)。结论：蛇床子散加减方联合CO₂点阵激光治疗外阴白色病变的效果显著，值得临床推广并使用。

Abstract: Objective: To investigate the application effect of modified Shechuangzi Decoction combined with CO₂ fractional laser in the treatment of vulvar leukoplakia, thereby providing new insights and practical references for clinical management of the disease. Methods: A total of 50 patients with vulvar leukoplakia admitted to our hospital from July 2025 to December 2025 were selected and randomly divided into a study group and a control group using a random number table method. The control group received CO₂ fractional laser therapy alone, while the study group received modified Shechuangzi Decoction in addition to the same laser treatment. Clinical symptom scores, inflammatory cytokine levels, quality of life, and the incidence of adverse reactions were statistically analyzed before and after treatment. Differences between the two groups were compared to evaluate the clinical efficacy of the combined therapy. Results: The study group demonstrated superior outcomes compared to the control group in terms of clinical symptom scores, inflammatory cytokine levels, quality of life, and the incidence of adverse reactions (P < 0.05). Conclusion: The combination of modified Shechuangzi Decoction and CO₂ fractional laser exhibits significant therapeutic efficacy in treating vulvar leukoplakia and is worthy of clinical promotion and application.