蛋白水凝胶在肝脏疾病治疗与再生医学中的应用研究

Research on the Application of Protein Hydrogel in the Treatment of Liver Diseases and Regenerative Medicine

摘要: 肝脏作为人体拥有合成、解毒、免疫、消化等多项功能的最大实质性器官，在维持人体正常运转中不可缺少，但肝脏疾病却也并不少见，并且面临着药物治疗靶向差、系统毒性大，肝移植存在免疫排斥、费用高昂；蛋白水凝胶卓越的生物相容性与可降解性，能够高度模拟肝细胞的天然生长微环境，在各种肝脏疾病治疗中已有应用。本文就常见的几种蛋白水凝胶在治疗肝脏疾病的应用做出汇总，并就蛋白水凝胶的应用提出局限与难题，最后展望未来的研究方向，以期为蛋白水凝胶的临床应用治疗提供新的思路和参考。

Abstract: As the largest substantive organ with many functions such as synthesis, detoxification, immunity, digestion and so on, the liver is indispensable in maintaining the normal operation of the human body, but liver diseases are not uncommon, and it faces poor drug targeting, great systemic toxicity, immune rejection and high cost in liver transplantation. Protein hydrogel has excellent biocompatibility and biodegradability, which can highly simulate the natural growth microenvironment of hepatocytes and has been used in the treatment of various liver diseases. In this paper, the application of several common protein hydrogels in the treatment of liver diseases is summarized, and the limitations and problems of the application of protein hydrogels are put forward. Finally, the future research direction is prospected, in order to provide new ideas and references for the clinical application and treatment of protein hydrogels.