轻型小动脉闭塞型急性后循环脑梗死患者早期神经功能恶化的危险因素分析
Risk Factors for Early Neurological Deterioration in Patients with Mild Small Artery Occlusion Acute Posterior Circulation Cerebral Infarction
DOI: 10.12677/acm.2026.161347, PDF,   
作者: 冯千正*：承德医学院研究生学院，河北 承德；邢台市人民医院神经内四科，河北 邢台；李婷婷：河北医科大学研究生学院，河北 石家庄；曹旭鑫：承德医学院研究生学院，河北 承德；张 静#：邢台市人民医院神经内四科，河北 邢台
关键词: 急性后循环脑梗死；早期神经功能恶化；危险因素；轻型；小动脉闭塞型；Acute Posterior Circulation Cerebral Infarction； Early Neurological Deterioration； Risk Factors； Mild Type； Small Artery Occlusion Type
摘要: 目的：探讨轻型小动脉闭塞型急性后循环脑梗死(APCCI)患者发生早期神经功能恶化(END)的危险因素。方法：回顾性分析90例轻型小动脉闭塞型后循环急性脑梗死患者的临床资料，根据入院后72 h内是否发生END分为END组15例和无END组75例。比较2组的一般特征及临床资料，采用Logistic回归模型分析轻型小动脉闭塞型后循环急性脑梗死患者发生END的独立危险因素。结果：90例轻型小动脉闭塞型APCCI患者发生END15例(16.67%)。多因素Logistic回归分析结果显示，血小板计数减少(OR = 0.982, 95% CI = 0.967~0.996, P = 0.012)、椎动脉狭窄(OR = 18.737, 95% CI = 1.929~181.992, P = 0.012)为轻型小动脉闭塞型后循环急性脑梗死患者发生END的独立危险因素(均P < 0.05)。结论：血小板计数减少、椎动脉狭窄的轻型小动脉闭塞型后循环急性脑梗死患者发生END的风险增大，临床上对该类患者进行治疗时应综合评估上述因素。
Abstract: Objective: This paper aims to explore the risk factors for early neurological deterioration (END) in patients with mild small artery occlusion acute posterior circulation cerebral infarction (APCCI). Methods: The clinical data of 90 patients with mild small artery occlusion posterior circulation acute cerebral infarction were retrospectively analyzed. The patients were divided into the END group (n = 15) and the non-END group (n = 75) based on whether END occurred within 72 hours after admission. The general characteristics and clinical data of the two groups were compared. Logistic regression model was used to analyze the independent risk factors for END in patients with mild small artery occlusion posterior circulation acute cerebral infarction. Results: Among the 90 patients with mild small artery occlusion APCCI, 15 cases (16.67%) experienced END. The results of multivariate Logistic regression analysis showed that decreased platelet count (OR = 0.982, 95% CI = 0.967~0.996, P = 0.012) and vertebral artery stenosis (OR = 18.737, 95% CI = 1.929~181.992, P = 0.012) were independent risk factors for END in patients with mild small artery occlusion posterior circulation acute cerebral infarction (all P < 0.05). Conclusion: The risk of END increases in patients with mild small artery occlusion posterior circulation acute cerebral infarction with decreased platelet count and vertebral artery stenosis. Clinically, when treating such patients, the above factors should be comprehensively evaluated.
文章引用：冯千正, 李婷婷, 曹旭鑫, 张静. 轻型小动脉闭塞型急性后循环脑梗死患者早期神经功能恶化的危险因素分析[J]. 临床医学进展, 2026, 16(1): 2858-2865. https://doi.org/10.12677/acm.2026.161347

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