拉贝洛尔联合硝苯地平对妊娠期高血压疾病患者凝血及血管内皮功能的调控作用与疗效研究进展

Research Progress on the Regulatory Effects and Therapeutic Efficacy of Labetalol Combined with Nifedipine on Coagulation and Vascular Endothelial Function in Patients with Gestational Hypertension

摘要: 妊娠期高血压疾病是一种妊娠期特有的疾病，严重威胁孕妇和胎儿健康。拉贝洛尔与硝苯地平的联合治疗方案近年来在临床应用中优势明显。研究表明，联合用药能通过多途径协同联合降低血压，改善血管内皮功能，调节凝血纤溶系统，降低不良母婴结局发生率。现就拉贝洛尔与硝苯地平联合使用对妊娠期高血压疾病患者凝血功能及血管内皮功能的调控作用与临床疗效予以综述，为妊娠期高血压疾病的临床治疗提供新的思路。

Abstract: Hypertensive disorders in pregnancy are specific diseases during pregnancy that seriously threaten the health of pregnant women and their fetuses. The combined treatment of labetalol and nifedipine has shown significant advantages in clinical application in recent years. Studies have shown that the combined use of these drugs can lower blood pressure through multiple pathways, improve vascular endothelial function, regulate the coagulation and fibrinolysis system, and reduce the incidence of adverse maternal and neonatal outcomes. This article reviews the regulatory effects of the combined use of labetalol and nifedipine on the coagulation function and vascular endothelial function of patients with hypertensive disorders in pregnancy and their clinical efficacy, providing new ideas for the clinical treatment of hypertensive disorders in pregnancy.