人工智能在腹主动脉瘤疾病中的应用
Applications of Artificial Intelligence in Abdominal Aortic Aneurysm
DOI: 10.12677/acm.2026.162474, PDF,   
作者: 贺紫灵, 杨 超*:暨南大学第二临床医学院(深圳市人民医院)心脏外科,广东 深圳
关键词: 腹主动脉瘤人工智能机器学习深度学习破裂风险预测Abdominal Aortic Aneurysm Artificial Intelligence Machine Learning Deep Learning Rupture Risk Prediction
摘要: 目的:综述人工智能(AI)在腹主动脉瘤(AAA)破裂风险预测中的研究进展。方法:检索近5年国内外AI在AAA中的应用文献,从影像分割、瘤体生长预测、破裂风险评估及生物力学分析等方面总结AI方法的技术原理与临床效果。结果:深度学习在CT影像自动分割中显著提升主动脉外壁、腔内血栓识别精度,Dice系数普遍>0.9;机器学习模型可融合形态学、血流动力学与分子组学特征,破裂风险预测AUC达0.85~0.90。AI模型在EVAR术后内漏检测与并发症预测中亦表现优异。结论:AI可显著提升AAA破裂风险预测的精准度与个体化水平,但仍受限于数据标准化、模型可解释性及临床转化。未来应整合多模态信息并建立多中心协作平台,以实现智能化、可推广的风险评估体系。
Abstract: Objective: To review recent advances in the application of Artificial Intelligence (AI) for predicting the rupture risk of Abdominal Aortic Aneurysm (AAA). Methods: Literature published within the past five years regarding AI applications in AAA was systematically reviewed. Technical principles and clinical efficacy were analyzed across imaging segmentation, aneurysm growth prediction, rupture risk assessment, and biomechanical analysis. Results: Deep learning significantly improves CT-based segmentation accuracy for aortic wall and intraluminal thrombus (Dice > 0.9). Machine learning models integrating morphological, hemodynamic, and omics features achieved AUCs of 0.85~0.90 for rupture prediction. AI systems also perform well in detecting endoleak and postoperative complications after EVAR. Conclusion: AI enhances precision and individualization in AAA rupture risk prediction; however, limitations persist regarding data standardization, model interpretability, and clinical translation. Future efforts should focus on multimodal data integration and multicenter cooperation to achieve intelligent and generalizable risk assessment frameworks.
文章引用:贺紫灵, 杨超. 人工智能在腹主动脉瘤疾病中的应用[J]. 临床医学进展, 2026, 16(2): 957-964. https://doi.org/10.12677/acm.2026.162474

参考文献

[1] Ullery, B.W., Hallett, R.L. and Fleischmann, D. (2018) Epidemiology and Contemporary Management of Abdominal Aortic Aneurysms. Abdominal Radiology, 43, 1032-1043. [Google Scholar] [CrossRef] [PubMed]
[2] Lieberg, J., Pruks, L.-L., Kals, M., Paapstel, K., Aavik, A. and Kals, J. (2017) Mortality after Elective and Ruptured Abdominal Aortic Aneurysm Surgical Repair: 12-Year Single-Center Experience of Estonia. Scandinavian Journal of Surgery, 107, 152-157. [Google Scholar] [CrossRef] [PubMed]
[3] Jeong, J., Kim, J., Kim, N., Cho, J., Kim, J., Oh, J., et al. (2016) Risk Diagnosis Based on Diameter of Abdominal Aortic Aneurysm. Technology and Health Care, 24, S569-S575. [Google Scholar] [CrossRef] [PubMed]
[4] Murali Krishna, S., Morton, S.K., Li, J. and Golledge, J. (2020) Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture. International Journal of Molecular Sciences, 21, Article No. 7250. [Google Scholar] [CrossRef] [PubMed]
[5] Gasser, T.C. (2016) Biomechanical Rupture Risk Assessment—A Consistent and Objective Decision-Making Tool for Abdominal Aortic Aneurysm Patients. Aorta, 4, 42-60. [Google Scholar] [CrossRef
[6] Golledge, J., Norman, P.E., Murphy, M.P. and Dalman, R.L. (2017) Challenges and Opportunities in Limiting Abdominal Aortic Aneurysm Growth. Journal of Vascular Surgery, 65, 225-233. [Google Scholar] [CrossRef] [PubMed]
[7] Sidik, A.I., Komarov, R.N., Gawusu, S., Moomin, A., Al-Ariki, M.K., Elias, M., et al. (2024) Application of Artificial Intelligence in Cardiology: A Bibliometric Analysis. Cureus, 16, e66925. [Google Scholar] [CrossRef] [PubMed]
[8] Xiang, Y., Zhao, L., Liu, Z., Wu, X., Chen, J., Long, E., et al. (2020) Implementation of Artificial Intelligence in Medicine: Status Analysis and Development Suggestions. Artificial Intelligence in Medicine, 102, Article ID: 101780. [Google Scholar] [CrossRef] [PubMed]
[9] Chen, D., Krycia, M., Avondo, J. and Cavallo, J. (2025) Performance Assessment of an Artificial Intelligence Algorithm for Opportunistic Screening of Abdominal Aortic Aneurysms. Clinical Imaging, 125, Article ID: 110550. [Google Scholar] [CrossRef] [PubMed]
[10] Guo, J., Lareyre, F., Lee, R., Teraa, M., Delingette, H. and Raffort, J. (2025) Artificial Intelligence and Machine Learning for Risk Prediction of Abdominal Aortic Aneurysm Growth and Rupture. Angiology. [Google Scholar] [CrossRef
[11] Abdolmanafi, A., Forneris, A., Moore, R.D. and Di Martino, E.S. (2023) Deep-Learning Method for Fully Automatic Segmentation of the Abdominal Aortic Aneurysm from Computed Tomography Imaging. Frontiers in Cardiovascular Medicine, 9, Article ID: 1040053. [Google Scholar] [CrossRef] [PubMed]
[12] López-Linares, K., Aranjuelo, N., Kabongo, L., Maclair, G., Lete, N., Ceresa, M., et al. (2018) Fully Automatic Detection and Segmentation of Abdominal Aortic Thrombus in Post-Operative CTA Images Using Deep Convolutional Neural Networks. Medical Image Analysis, 46, 202-214. [Google Scholar] [CrossRef] [PubMed]
[13] López-Linares, K., Stephens, M., García, I., Macía, I., González Ballester, M.Á. and José Estepar, R.S. (2019) Abdominal Aortic Aneurysm Segmentation Using Convolutional Neural Networks Trained with Images Generated with a Synthetic Shape Model. In: Liao, H.E., et al., Eds., Machine Learning and Medical Engineering for Cardiovascular Health and Intravascular Imaging and Computer Assisted Stenting, Springer International Publishing, 167-174. [Google Scholar] [CrossRef] [PubMed]
[14] Caradu, C., Pouncey, A., Lakhlifi, E., Brunet, C., Bérard, X. and Ducasse, E. (2022) Fully Automatic Volume Segmentation Using Deep Learning Approaches to Assess Aneurysmal Sac Evolution after Infrarenal Endovascular Aortic Repair. Journal of Vascular Surgery, 76, 620-630.e3. [Google Scholar] [CrossRef] [PubMed]
[15] Siriapisith, T., Kusakunniran, W. and Haddawy, P. (2019) 3D Segmentation of Exterior Wall Surface of Abdominal Aortic Aneurysm from CT Images Using Variable Neighborhood Search. Computers in Biology and Medicine, 107, 73-85. [Google Scholar] [CrossRef] [PubMed]
[16] Ginzburg, D., Nowak, S., Attenberger, U., Luetkens, J., Sprinkart, A.M. and Kuetting, D. (2024) Computer Tomography-Based Assessment of Perivascular Adipose Tissue in Patients with Abdominal Aortic Aneurysms. Scientific Reports, 14, Article No. 20512. [Google Scholar] [CrossRef] [PubMed]
[17] Hahn, S., Perry, M., Morris, C.S., Wshah, S. and Bertges, D.J. (2020) Machine Deep Learning Accurately Detects Endoleak after Endovascular Abdominal Aortic Aneurysm Repair. JVS-Vascular Science, 1, 5-12. [Google Scholar] [CrossRef] [PubMed]
[18] Hirata, K., Nakaura, T., Nakagawa, M., Kidoh, M., Oda, S., Utsunomiya, D., et al. (2020) Machine Learning to Predict the Rapid Growth of Small Abdominal Aortic Aneurysm. Journal of Computer Assisted Tomography, 44, 37-42. [Google Scholar] [CrossRef] [PubMed]
[19] Lee, R., Jarchi, D., Perera, R., Jones, A., Cassimjee, I., Handa, A., et al. (2018) Applied Machine Learning for the Prediction of Growth of Abdominal Aortic Aneurysm in Humans. EJVES Short Reports, 39, 24-28. [Google Scholar] [CrossRef] [PubMed]
[20] Li, B., Aljabri, B., Beaton, D., Al-Omran, L., Hussain, M.A., Lee, D.S., et al. (2025) Predicting Outcomes Following Open Abdominal Aortic Aneurysm Repair Using Machine Learning. Scientific Reports, 15, Article No. 14362. [Google Scholar] [CrossRef] [PubMed]
[21] Wang, Y., Xiong, F., Leach, J., Kao, E., Tian, B., Zhu, C., et al. (2023) Contrast-Enhanced CT Radiomics Improves the Prediction of Abdominal Aortic Aneurysm Progression. European Radiology, 33, 3444-3454. [Google Scholar] [CrossRef] [PubMed]
[22] Alloisio, M., Siika, A., Roy, J., Zerwes, S., Hyhlik-duerr, A. and Gasser, T.C. (2024) Merging Geometrical, Biomechanical, and Clinical Data to Assess the Rupture Risk of Abdominal Aortic Aneurysms. EJVES Vascular Forum, 62, S21. [Google Scholar] [CrossRef
[23] Mansouri, M., Therasse, E., Montagnon, E., Zhan, Y.O., Lessard, S., Roy, A., et al. (2023) CT Analysis of Aortic Calcifications to Predict Abdominal Aortic Aneurysm Rupture. European Radiology, 34, 3903-3911. [Google Scholar] [CrossRef] [PubMed]
[24] Skovbo, J.S., Andersen, N.S., Obel, L.M., Laursen, M.S., Riis, A.S., Houlind, K.C., et al. (2025) Individual Risk Assessment for Rupture of Abdominal Aortic Aneurysm Using Artificial Intelligence. European Journal of Vascular and Endovascular Surgery, 69, e244. [Google Scholar] [CrossRef
[25] Rijswijk, R.E., Bogdanovic, M., Roy, J., et al. (2025) Multimodal Artificial Intelligence Model for Prediction of Abdominal Aortic Aneurysm Shrinkage after Endovascular Repair (the ART in EVAR Study). Journal of Endovascular Therapy.
[26] Chung, T.K., Gueldner, P.H., Aloziem, O.U., Liang, N.L. and Vorp, D.A. (2024) An Artificial Intelligence Based Abdominal Aortic Aneurysm Prognosis Classifier to Predict Patient Outcomes. Scientific Reports, 14, Article No. 3390. [Google Scholar] [CrossRef] [PubMed]
[27] Li, D., Zhang, G., Du, P., Cao, C., He, X., Lv, Y., et al. (2025) Machine Learning Combined with Omics-Based Approaches Reveals T-Lymphocyte Cellular Fate Imbalance in Abdominal Aortic Aneurysm. BMC Biology, 23, Article No. 280. [Google Scholar] [CrossRef
[28] Han, Z., Lu, X., He, Y., Zhang, T., Zhou, Z., Zhang, J., et al. (2024) Integration of Bulk/scRNA-seq and Multiple Machine Learning Algorithms Identifies PIM1 as a Biomarker Associated with Cuproptosis and Ferroptosis in Abdominal Aortic Aneurysm. Frontiers in Immunology, 15, Article ID: 1486209. [Google Scholar] [CrossRef] [PubMed]
[29] Zhang, L., Yang, H., Zhou, C., Li, Y., Long, Z., Li, Q., et al. (2024) Artificial Intelligence-Driven Multiomics Predictive Model for Abdominal Aortic Aneurysm Subtypes to Identify Heterogeneous Immune Cell Infiltration and Predict Disease Progression. International Immunopharmacology, 138, Article ID: 112608. [Google Scholar] [CrossRef] [PubMed]
[30] Lindquist Liljeqvist, M., Bogdanovic, M., Siika, A., Gasser, T.C., Hultgren, R. and Roy, J. (2021) Geometric and Biomechanical Modeling Aided by Machine Learning Improves the Prediction of Growth and Rupture of Small Abdominal Aortic Aneurysms. Scientific Reports, 11, Article No. 18040. [Google Scholar] [CrossRef] [PubMed]
[31] Chung, T.K., Liang, N.L. and Vorp, D.A. (2022) Artificial Intelligence Framework to Predict Wall Stress in Abdominal Aortic Aneurysm. Applications in Engineering Science, 10, Article ID: 100104. [Google Scholar] [CrossRef] [PubMed]
[32] Rezaeitaleshmahalleh, M., Lyu, Z., Mu, N., Wang, M., Zhang, X., Rasmussen, T.E., et al. (2024) Computational Hemodynamics-Based Growth Prediction for Small Abdominal Aortic Aneurysms: Laminar Simulations versus Large Eddy Simulations. Annals of Biomedical Engineering, 52, 3078-3097. [Google Scholar] [CrossRef] [PubMed]
[33] Zhou, M., Shi, Z., Li, X., Cai, L., Ding, Y., Si, Y., et al. (2021) Prediction of Distal Aortic Enlargement after Proximal Repair of Aortic Dissection Using Machine Learning. Annals of Vascular Surgery, 75, 332-340. [Google Scholar] [CrossRef] [PubMed]
[34] 陈广新, 才莹, 郭金兴, 等. 基于血流动力学与形态学特征融合的动脉瘤破裂风险机器学习预测研究[J]. 新一代信息技术, 2023, 6(23): 9-14.