REG4蛋白在结肠癌中的角色：从分子机制到临床应用的综述
The Role of REG4 Protein in Colon Cancer: A Review from Molecular Mechanisms to Clinical Applications
DOI: 10.12677/acm.2026.162530, PDF,    科研立项经费支持
作者: 李诗琪, 周传意, 吴定洲*, 周鹏宇*：湖南师范大学附属岳阳医院，湖南 岳阳
关键词: REG4；结肠癌；生物标志物；信号通路；化疗抵抗；靶向治疗；REG4； Colorectal Cancer； Biomarker； Signal Pathway； Chemotherapy Resistance； Targeted Therapy
摘要: 再生基因家族成员4 (Regenerating Islet-derived Family Member 4, REG4)是一种分泌性蛋白，属于钙依赖性C型凝集素超家族。其在正常胃肠道组织中局限表达，主要功能涉及黏膜保护、增殖与分化。近年研究发现，REG4在结肠癌中呈现显著的高表达，并通过激活多条关键信号通路，在肿瘤细胞的增殖、凋亡逃逸、侵袭、转移、化疗抵抗以及干细胞特性维持中发挥核心作用。本综述系统阐述了REG4的分子结构与生物学功能，详细分析了其在结肠癌中异常表达的调控机制，并深入探讨了其通过EGFR/Akt、MAPK、STAT3等通路促进肿瘤恶性进展的分子机理。此外，本文重点评述了REG4作为结肠癌诊断、预后判断和疗效预测的新型生物标志物的巨大潜力，以及其作为创新治疗靶点的最新研究进展。最后，我们对当前研究的挑战和未来转化医学的方向进行了展望，旨在为结肠癌的精准医疗提供新的理论依据和策略方向。
Abstract: Regenerating Islet-derived Family Member 4 (REG4) is a secretory protein that belongs to the calcium-dependent C-type lectin superfamily. It is expressed predominantly in normal gastrointestinal tissue and is mainly involved in mucosal protection, proliferation, and differentiation. Recent studies have revealed that REG4 is significantly overexpressed in colorectal cancer, where it plays a critical role in tumor cell proliferation, apoptotic evasion, invasion, metastasis, chemotherapy resistance, and the maintenance of stem cell properties by activating multiple key signaling pathways. This review systematically describes the molecular structure and biological functions of REG4, analyzes the regulatory mechanisms of its abnormal expression in colorectal cancer in detail, and further explores its molecular mechanisms that promote tumor malignancy through pathways such as EGFR/Akt, MAPK, and STAT3. Additionally, this article highlights the tremendous potential of REG4 as a novel biomarker for the diagnosis, prognostic assessment, and therapeutic prediction of colorectal cancer, as well as the latest research developments regarding its role as an innovative therapeutic target. Finally, we discuss the challenges faced in current research and prospects for future translational medicine, aiming to provide new theoretical foundations and strategic directions for precision medicine in colorectal cancer.
文章引用：李诗琪, 周传意, 吴定洲, 周鹏宇. REG4蛋白在结肠癌中的角色：从分子机制到临床应用的综述[J]. 临床医学进展, 2026, 16(2): 1432-1439. https://doi.org/10.12677/acm.2026.162530

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