对比敏感度在近视中的应用研究进展
Research Progress on the Application of Contrast Sensitivity in Myopia
DOI: 10.12677/acm.2026.162561, PDF,   
作者: 李可亦*, 李 华：重庆医科大学附属永川医院眼科，重庆
关键词: 对比敏感度；近视；光感受器；Contrast Sensitivity； Myopia； Photoreceptor
摘要: 近视是全球高发眼部疾病，若控制不佳，眼轴会持续过度增长，进而引发不可逆眼部病理性改变。长期以来，对于近视患者视力的评估常优先采用对数视力表，但其对部分视觉损伤及临床场景中的真实视觉效果评估欠佳。对比敏感度(Contrast Sensitivity, CS)作为一种更敏锐的视功能检测手段，可弥补这些不足。同时，近视进展可反映到视网膜微观光感受器等结构改变，CS可无创间接地对该改变进行反映。本文聚焦于CS在近视中的应用，旨在全面总结CS在近视领域的应用进展，为后续相关研究及临床应用提供参考。
Abstract: Myopia is a globally prevalent ocular disorder. If poorly managed, the axial length will continue to increase excessively, leading to irreversible pathological changes in the eye. For a long time, the logarithmic visual acuity chart has been the preferred tool for evaluating visual acuity in myopic patients; however, it shows limitations in evaluating certain visual impairments and the actual visual performance in clinical scenarios. Contrast Sensitivity (CS), as a more sensitive assessment tool for visual function, can make up for these deficiencies. Meanwhile, the progression of myopia can be reflected in structural changes such as the photoreceptors of the retina, and CS can non-invasively and indirectly reflect such changes. This paper focuses on the application of CS in myopia, aiming to comprehensively summarize the research progress of CS in the field of myopia and provide a reference for subsequent related research and clinical application.
文章引用：李可亦, 李华. 对比敏感度在近视中的应用研究进展[J]. 临床医学进展, 2026, 16(2): 1694-1701. https://doi.org/10.12677/acm.2026.162561

参考文献

[1] Arden, G.B. and Jacobson, J.J. (1978) A Simple Grating Test for Contrast Sensitivity: Preliminary Results Indicate Value in Screening for Glaucoma. Investigative Ophthalmology & Visual Science, 17, 23-32.
[2] Pelli, D.G. and Bex, P. (2013) Measuring Contrast Sensitivity. Vision Research, 90, 10-14. [Google Scholar] [CrossRef] [PubMed]
[3] Jong Monica, Resnikoff Serge, Tan Kah Ooi, 等. 亚洲近视管理共识[J]. 中华眼视光学与视觉科学杂志, 2022, 24(3): 161-169.
[4] 中华医学会眼科学分会眼视光学组, 中国医师协会眼科医师分会眼视光专业委员会, 中国非公立医疗机构协会眼科专业委员会视光学组. 近视管理白皮书(2025) [J]. 中华眼视光学与视觉科学杂志, 2025, 27(7): 481-489.
[5] Du, R., Xie, S., Igarashi-Yokoi, T., Watanabe, T., Uramoto, K., Takahashi, H., et al. (2021) Continued Increase of Axial Length and Its Risk Factors in Adults with High Myopia. JAMA Ophthalmology, 139, 1096-1103. [Google Scholar] [CrossRef] [PubMed]
[6] Morgan, I.G., French, A.N., Ashby, R.S., Guo, X., Ding, X., He, M., et al. (2018) The Epidemics of Myopia: Aetiology and Prevention. Progress in Retinal and Eye Research, 62, 134-149. [Google Scholar] [CrossRef] [PubMed]
[7] Neitz, J. and Neitz, M. (2024) Diffusion Optics Technology (DOT): A Myopia Control Spectacle Lens Based on Contrast Theory. Translational Vision Science & Technology, 13, Article 42. [Google Scholar] [CrossRef] [PubMed]
[8] Li, K.Y., Tiruveedhula, P. and Roorda, A. (2010) Intersubject Variability of Foveal Cone Photoreceptor Density in Relation to Eye Length. Investigative Opthalmology & Visual Science, 51, 6858-6867. [Google Scholar] [CrossRef] [PubMed]
[9] Park, S.P., Chung, J.K., Greenstein, V., Tsang, S.H. and Chang, S. (2013) A Study of Factors Affecting the Human Cone Photoreceptor Density Measured by Adaptive Optics Scanning Laser Ophthalmoscope. Experimental Eye Research, 108, 1-9. [Google Scholar] [CrossRef] [PubMed]
[10] Crewther, D.P. (2000) The Role of Photoreceptors in the Control of Refractive State. Progress in Retinal and Eye Research, 19, 421-457. [Google Scholar] [CrossRef] [PubMed]
[11] Shen, Y., Ye, X., Zhou, X., Yu, J., Zhang, C., He, S., et al. (2024) In Vivo Assessment of Cone Loss and Macular Perfusion in Children with Myopia. Scientific Reports, 14, Article No. 26373. [Google Scholar] [CrossRef] [PubMed]
[12] Xin, X., Guo, Q., Ming, S., Liu, C., Wang, Z. and Lei, B. (2021) High-Resolution Image Analysis Reveals a Decrease in Lens Thickness and Cone Density in a Cohort of Young Myopic Patients. Frontiers in Medicine, 8, Article 796778. [Google Scholar] [CrossRef] [PubMed]
[13] Wang, J., Liu, X., Huang, J., Deng, R., Zhao, S., Chen, Y., et al. (2024) Reduced Contrast Sensitivity Function Is Correlated with Changes to Cone Photoreceptors in Simple High Myopia. Frontiers in Neuroscience, 18, Article 1274651. [Google Scholar] [CrossRef] [PubMed]
[14] Liu, X., Wang, Y., Ying, X., Zhang, F., Huang, J., Yu, H., et al. (2022) Contrast Sensitivity Is Associated with Chorioretinal Thickness and Vascular Density of Eyes in Simple Early-Stage High Myopia. Frontiers in Medicine, 9, Article 847817. [Google Scholar] [CrossRef] [PubMed]
[15] Przekoracka, K., Michalak, K., Olszewski, J., Zeri, F., Michalski, A., Paluch, J., et al. (2020) Contrast Sensitivity and Visual Acuity in Subjects Wearing Multifocal Contact Lenses with High Additions Designed for Myopia Progression Control. Contact Lens and Anterior Eye, 43, 33-39. [Google Scholar] [CrossRef] [PubMed]
[16] 李风鸣. 眼科全书[M]. 北京: 人民卫生出版社, 1996: 390-391.
[17] Leung, T., Li, R.W. and Kee, C. (2023) Brief Adaptation to Astigmatism Reduces Meridional Anisotropy in Contrast Sensitivity. Investigative Opthalmology & Visual Science, 64, Article 4. [Google Scholar] [CrossRef] [PubMed]
[18] Stoimenova, B.D. (2007) The Effect of Myopia on Contrast Thresholds. Investigative Opthalmology & Visual Science, 48, 2371-2374. [Google Scholar] [CrossRef] [PubMed]
[19] McKinney, P. and Zukowski, M.L. (1989) The Value of Tear Film Breakup and Schirmerʼs Tests in Preoperative Blepharoplasty Evaluation. Plastic and Reconstructive Surgery, 84, 572-576. [Google Scholar] [CrossRef] 
[20] 田春慧, 雷秀丽, 连丽英, 等. 对比敏感度在近视初期患者检查中的作用[J]. 中国斜视与小儿眼科杂志, 2018, 26(4): 22-24.
[21] Ye, Y., Liu, F., Xian, Y., Li, M., Niu, L., Zhou, X., et al. (2025) Correlation of Contrast Sensitivity at Low Spatial Frequencies with Myopic Shift in Chinese Children. BMC Ophthalmology, 25, Article No. 99. [Google Scholar] [CrossRef] [PubMed]
[22] Comune, C., Montorio, D. and Cennamo, G. (2021) Optical Coherence Tomography Angiography in Myopic Peripapillary Intrachoroidal Cavitation Complicated by Choroidal Neovascularization. European Journal of Ophthalmology, 31, 1920-1924. [Google Scholar] [CrossRef] [PubMed]
[23] Na, H., Lee, E.J., Lee, S.H. and Kim, T. (2020) Evaluation of Peripapillary Choroidal Microvasculature to Detect Glaucomatous Damage in Eyes with High Myopia. Journal of Glaucoma, 29, 39-45. [Google Scholar] [CrossRef] [PubMed]
[24] Du, Y., Meng, J., He, W., Qi, J., Lu, Y. and Zhu, X. (2024) Complications of High Myopia: An Update from Clinical Manifestations to Underlying Mechanisms. Advances in Ophthalmology Practice and Research, 4, 156-163. [Google Scholar] [CrossRef] [PubMed]
[25] Lee, J.H., Lee, S.C., Kim, S.H., Koh, H.J., Kim, S.S., Byeon, S.H., et al. (2017) Choroidal Thickness and Chorioretinal Atrophy in Myopic Choroidal Neovascularization with Anti-Vascular Endothelial Growth Factor Therapy. Retina, 37, 1516-1522. [Google Scholar] [CrossRef] [PubMed]
[26] Iacono, P., Battaglia Parodi, M., Selvi, F., Parravano, M.C., Chiaravalloti, A., Varano, M., et al. (2017) Factors Influencing Visual Acuity in Patients Receiving Anti-Vascular Endothelial Growth Factor for Myopic Choroidal Neovascularization. Retina, 37, 1931-1941. [Google Scholar] [CrossRef] [PubMed]
[27] 韩丁, 王宇欣, 贺美男, 等. 同心双焦设计离焦软镜与单焦软镜的主观视觉效果比较[J]. 中华眼视光学与视觉科学杂志, 2024, 26(11): 816-823.
[28] García-Marqués, J.V., Macedo-De-Araújo, R.J., Cerviño, A., García-Lázaro, S., McAlinden, C. and González-Méijome, J.M. (2020) Comparison of Short-Term Light Disturbance, Optical and Visual Performance Outcomes between a Myopia Control Contact Lens and a Single-Vision Contact Lens. Ophthalmic and Physiological Optics, 40, 718-727. [Google Scholar] [CrossRef] [PubMed]
[29] Li, X., Ding, C., Li, Y., Lim, E.W., Gao, Y., Fermigier, B., et al. (2021) Influence of Lenslet Configuration on Short-Term Visual Performance in Myopia Control Spectacle Lenses. Frontiers in Neuroscience, 15, Article 667329. [Google Scholar] [CrossRef] [PubMed]
[30] 李晓莹, 马薇, 宋雨桐, 等. 多区正向光学离焦镜片对双眼视功能和视觉质量影响的随机双盲对照研究[J]. 中华实验眼科杂志, 2025, 43(2): 130-137.
[31] Lu, W., Song, G., Zhang, Y., Lian, Y., Ma, K., Lu, Q., et al. (2023) The Effect of Orthokeratology Lenses on Optical Quality and Visual Function in Children. Frontiers in Neuroscience, 17, Article 1142524. [Google Scholar] [CrossRef] [PubMed]
[32] 王艳, 廖萱, 兰长骏, 等. 自适应光学视觉模拟器评价角膜塑形镜配戴前后的视觉质量变化[J]. 中华眼视光学与视觉科学杂志(中英文), 2025, 27(10): 747-753.
[33] Dorr, M., Wille, M., Viulet, T., Sanchez, E., Bex, P.J., Lu, Z., et al. (2015) Next-Generation Vision Testing: The Quick CSF. Current Directions in Biomedical Engineering, 1, 131-134. [Google Scholar] [CrossRef] 
[34] Hou, F., Lesmes, L.A., Kim, W., Gu, H., Pitt, M.A., Myung, J.I., et al. (2016) Evaluating the Performance of the Quick CSF Method in Detecting Contrast Sensitivity Function Changes. Journal of Vision, 16, Article 18. [Google Scholar] [CrossRef] [PubMed]
[35] Mena-Guevara, K.J., Piñero, D.P., Luque, M.J. and de Fez, D. (2024) The Measurement of Contrast Sensitivity in Near Vision: The Use of a Digital System vs. a Conventional Printed Test. Technologies, 12, Article 108. [Google Scholar] [CrossRef] 
[36] 王丽萍, 陆佳峰, 邱飞岳, 等. 度量对比敏感度阈值的自适应优化方法研究[J]. 小型微型计算机系统, 2022, 43(8): 1638-1643.
[37] Stellmann, J., Young, K., Pöttgen, J., Dorr, M. and Heesen, C. (2015) Introducing a New Method to Assess Vision: Computer-Adaptive Contrast-Sensitivity Testing Predicts Visual Functioning Better than Charts in Multiple Sclerosis Patients. Multiple Sclerosis Journal—Experimental, Translational and Clinical, 1, 1-8. [Google Scholar] [CrossRef] [PubMed]
[38] Anstice, N.S. and Phillips, J.R. (2011) Effect of Dual-Focus Soft Contact Lens Wear on Axial Myopia Progression in Children. Ophthalmology, 118, 1152-1161. [Google Scholar] [CrossRef] [PubMed]
[39] Jung, H., Han, S.U., Kim, S., Ahn, H., Jun, I., Lee, H.K., et al. (2022) Comparison of Two Different Contrast Sensitivity Devices in Young Adults with Normal Visual Acuity with or without Refractive Surgery. Scientific Reports, 12, Article No. 12882. [Google Scholar] [CrossRef] [PubMed]

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