血清骨膜蛋白与心肌纤维化在HOCM心肌切除术后预后评估中的研究进展

Research Progress of Serum Periosteal Protein and Myocardial Fibrosis in Prognosis Evaluation after HOCM Myocardial Resection

摘要: 本综述旨在探讨梗阻性肥厚型心肌病(obstructive hypertrophic cardiomyopathy, HCM)患者在接受心肌切除术前，其血清骨膜蛋白水平及心肌纤维化程度与术后转归之间的相关性。梗阻性肥厚型心肌病是一种常见的遗传性心脏病，患者往往面临严重的心功能障碍和不良预后。近年来，研究发现血清骨膜蛋白作为一种生物标志物，可能在评估心肌病患者的病情及术后恢复中发挥重要作用。同时，心肌纤维化程度被认为是影响术后心功能恢复的关键因素之一。通过分析现有文献，本文系统性地评估了血清骨膜蛋白与心肌纤维化在术后预后中的重要性。研究结果表明，术前的生物标志物水平与患者的术后恢复及心功能改善密切相关，为临床提供了重要的参考依据，提示在术前评估中考虑这些因素可能有助于优化患者的治疗方案。

Abstract: This review aims to investigate the correlation between serum periosteal protein levels and myocardial fibrosis and postoperative outcomes in patients with obstructive hypertrophic cardiomyopathy (HCM) before myocardial resection. Obstructive hypertrophic cardiomyopathy is a common genetic heart disease, and patients often face severe cardiac dysfunction and poor prognosis. In recent years, studies have found that serum periosteal protein, as a biomarker, may play an important role in evaluating the condition and postoperative recovery of patients with cardiomyopathy. At the same time, the degree of myocardial fibrosis is considered to be one of the key factors affecting the recovery of cardiac function after operation. By analyzing the existing literature, this paper systematically evaluated the importance of serum periosteal protein and myocardial fibrosis in postoperative prognosis. The results showed that the preoperative biomarker level was closely related to the postoperative recovery and cardiac function improvement of patients, which provided an important reference for clinical practice, suggesting that considering these factors in the preoperative evaluation may help to optimize the treatment plan of patients.