S100家族蛋白在胃癌腹膜转移中的作用及临床应用研究综述
Review on the Role and Clinical Applications of S100 Family Proteins in Peritoneal Metastasis of Gastric Cancer
DOI: 10.12677/acm.2026.162568, PDF,    科研立项经费支持
作者: 李 伟, 高陈杰, 刘桐炫：西安医学院研究生工作部，陕西 西安；高 攀：延安大学医学部，陕西 延安；普彦淞*：陕西省人民医院营养科，陕西 西安
关键词: 胃癌；S100家族；腹膜转移；Gastric Cancer； S100 Family； Peritoneal Metastasis
摘要: 胃癌是全球范围内发病率和死亡率较高的恶性肿瘤之一，腹膜转移是其常见的转移方式，也是导致患者预后不良的主要原因。S100家族蛋白作为一类钙结合蛋白，在肿瘤的发生、发展及转移过程中发挥着重要作用。本综述围绕S100家族蛋白与胃癌腹膜转移的基础理论、流行病学、诊断技术、治疗策略、争议点及未来展望展开系统阐述。通过对相关文献的综合分析，揭示S100家族蛋白在胃癌腹膜转移中的结构与功能特点、分子机制、流行病学特征、诊断价值、治疗潜力及存在的争议，并对其未来研究方向进行展望，为胃癌腹膜转移的精准诊断和治疗提供理论依据和新的思路。
Abstract: Gastric cancer remains a malignancy with significant global morbidity and mortality. Peritoneal metastasis is a common mode of dissemination and a primary contributor to poor patient prognosis. The S100 family of proteins, a group of calcium-binding proteins, plays a crucial role in tumor initiation, progression, and metastasis. This review comprehensively focuses on the fundamental theories, epidemiology, diagnostic techniques, therapeutic strategies, controversies, and future perspectives regarding S100 proteins in the context of gastric cancer peritoneal metastasis. Through a synthesis of relevant literature, it elucidates the structural and functional characteristics, molecular mechanisms, epidemiological features, diagnostic value, therapeutic potential, and existing controversies associated with S100 proteins in this process. Furthermore, it offers insights into future research directions, aiming to lay a theoretical foundation and provide novel perspectives for the precise diagnosis and treatment of peritoneal metastasis in gastric cancer.
文章引用：李伟, 高陈杰, 刘桐炫, 高攀, 普彦淞. S100家族蛋白在胃癌腹膜转移中的作用及临床应用研究综述[J]. 临床医学进展, 2026, 16(2): 1751-1760. https://doi.org/10.12677/acm.2026.162568

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