替罗非班联合丁苯酞治疗急性进展性前循环 脑梗死的研究
Study on the Treatment of Acute Progressive Anterior Circulation Cerebral Infarction with Tirofiban Combined with Butylphthalide
DOI: 10.12677/acm.2026.162572, PDF,   
作者: 张昕阳：北华大学临床医学院，吉林 吉林；陈 曦*：北华大学附属医院神经内科，吉林 吉林
关键词: 替罗非班；急性进展性脑梗死；前循环；丁苯酞；Tirofiban； Acute Progressive Cerebral Infarction； Anterior Circulation； Butylphthalide
摘要: 急性进展性前循环脑梗死是神经内科常见的危急重症，其致残率和死亡率居高不下，给患者家庭和社会带来沉重负担。尽管血管内治疗取得了显著进展，但如何有效遏制梗死进展、改善神经功能缺损仍是临床面临的重大挑战。本综述系统梳理该领域研究背景、核心药物机制及国内外临床证据，聚焦替罗非班(速效抗血小板药物)与丁苯酞(神经保护剂)的协同作用，提出“精准定位病灶 + 双重通路阻断”的创新治疗思路——通过先进影像技术明确病灶范围，同时针对“血小板聚集微栓子形成”与“缺血级联反应”两大致病情恶化的关键通路实施干预，为临床优化急性进展性前循环脑梗死治疗策略提供循证参考与理论支撑。
Abstract: Acute progressive anterior circulation cerebral infarction (APACI) is a common critical condition in neurology, with persistently high disability and mortality rates, imposing a heavy burden on patients’ families and society. Despite significant advancements in endovascular therapy, effectively halting infarction progression and improving neurological deficits remain major clinical challenges. This review systematically reviews the research background, core pharmacological mechanisms, and clinical evidence from domestic and international studies in this field, focusing on the synergistic effects of tirofiban (a rapid-acting antiplatelet drug) and butylphthalide (a neuroprotective agent). It proposes an innovative therapeutic approach of “precise lesion localization + dual pathway blockade”—using advanced imaging techniques to delineate the lesion extent while targeting two critical pathways that exacerbate the condition: “platelet aggregation and microembolism formation” and “ischemic cascade reaction”. This provides evidence-based reference and theoretical support for optimizing clinical strategies for acute progressive anterior circulation cerebral infarction.
文章引用：张昕阳, 陈曦. 替罗非班联合丁苯酞治疗急性进展性前循环 脑梗死的研究[J]. 临床医学进展, 2026, 16(2): 1792-1798. https://doi.org/10.12677/acm.2026.162572

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