头孢哌酮钠他唑巴坦钠降阶梯疗法治疗老年慢性阻塞性肺疾病对气道重塑及炎症因子的影响

The Influence of Cefoperazone Sodium and Tazobactam Sodium Step-Down Therapy on Airway Remodeling and Inflammatory Factors in the Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease

摘要: 目的：观察头孢哌酮钠他唑巴坦钠降阶梯疗法治疗老年慢性阻塞性肺疾病对气道炎症与基质降解相关生物标志物及炎症因子的影响。方法：选取我院老年慢性阻塞性肺疾病患者90例(2022年1月至2025年12月)，采用随机数字表法分为常规治疗的对照组(45例)与头孢哌酮钠他唑巴坦钠降阶梯疗法治疗的观察组(45例)。观察患者肺功能指标、气道炎症与基质降解相关生物标志物、炎症因子水平。结果：与对照组相比，观察组肺功能指标改善好，气道炎症与基质降解相关生物标志物改善好，炎症因子水平低，P < 0.05；两组痰培养阳性率及细菌谱分布对比，P > 0.05。结论：老年慢性阻塞性肺疾病治疗中采用头孢哌酮钠他唑巴坦钠降阶梯疗法有利于肺功能、气道炎症与基质降解相关生物标志物改善，降低炎症因子水平，值得借鉴。

Abstract: Objective: To observe the effects of cefoperazone sodium and tazobactam sodium step-down therapy on airway inflammation and matrix degradation-related biomarkers and inflammatory factors in the treatment of elderly patients with chronic obstructive pulmonary disease. Methods: A total of 90 elderly patients with chronic obstructive pulmonary disease in our hospital (from January 2022 to December 2025) were selected and randomly divided into a control group (45 cases) treated with conventional therapy and an observation group (45 cases) treated with cefoperazone sodium and tazobactam sodium stepwise therapy by random number table method. The pulmonary function indicators of the patients, biomarkers related to airway inflammation and matrix degradation, and the levels of inflammatory factors were observed. Results: Compared with the control group, the pulmonary function indicators in the observation group improved better, the biomarkers related to airway inflammation and matrix degradation improved better, and the levels of inflammatory factors were low, P < 0.05. The comparison of the positive rate of sputum culture and the distribution of bacterial spectra between the two groups showed P > 0.05. Conclusion: The stepwise therapy of cefoperazone sodium and tazobactam sodium in the treatment of elderly chronic obstructive pulmonary disease is beneficial for improving biomarkers related to lung function, airway inflammation and matrix degradation, and reducing the levels of inflammatory factors. It is worth learning from.