肠道菌群与特应性皮炎相关性的研究进展
Research Progress on the Correlation between Gut Microbiota and Atopic Dermatitis
DOI: 10.12677/acm.2026.162601, PDF,    科研立项经费支持
作者: 何通通, 郭 芸*：昆明医科大学第二附属医院皮肤科，云南 昆明
关键词: 特应性皮炎；肠道菌群；益生菌；Atopic Dermatitis； Gut Microbiota； Probiotics
摘要: 特应性皮炎(atopic dermatitis, AD)是皮肤科常见的慢性炎症性皮肤病，其发病率高、机制不清、治疗困难，对患者身心健康影响巨大。研究表明，AD的发病与遗传因素、环境暴露、皮肤屏障受损、免疫功能异常和微生物失衡相关。随着对“肠道–皮肤轴”研究的不断深入，发现肠道菌群平衡的破坏会导致皮肤免疫和新陈代谢紊乱，促进AD的发生；口服益生菌可通过重建肠道菌群和全身免疫反应的平衡、调节代谢缓解AD的临床表现。本文旨在综述肠道菌群与AD相关性的最新研究进展。
Abstract: Atopic dermatitis (AD) is a common chronic inflammatory skin disease in dermatology, with a high incidence rate, unclear mechanism, and difficult treatment, which has a significant impact on the physical and mental health of patients. Research shows that the onset of AD is related to genetic factors, environmental exposure, impaired skin barrier, abnormal immune function, and microbial imbalance. With the continuous deepening of research on the “gut-skin axis”, it has been found that the disruption of intestinal flora balance can lead to skin immune and metabolic disorders, promoting the occurrence of AD; oral probiotics can alleviate the clinical manifestations of AD by restoring the balance of intestinal flora and systemic immune responses and regulating metabolism. This article aims to review the latest research progress on the correlation between intestinal flora and AD.
文章引用：何通通, 郭芸. 肠道菌群与特应性皮炎相关性的研究进展[J]. 临床医学进展, 2026, 16(2): 2043-2048. https://doi.org/10.12677/acm.2026.162601

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