代谢相关脂肪性肝病的研究进展与展望
Research Progress and Prospect of Metabolic-Associated Fatty Liver Disease
DOI: 10.12677/acm.2026.162627, PDF,   
作者: 兰少宏：西安医学院全科医学院，陕西 西安；陈晓林：娄底市第一人民医院超声科，湖南 娄底
关键词: 代谢相关脂肪性肝病；胰岛素抵抗；发病机制；诊断；治疗；Metabolic-Associated Fatty Liver Disease； Insulin Resistance； Pathogenesis； Diagnosis； Treatment
摘要: 代谢相关脂肪性肝病(MAFLD)是全球第一大慢性肝病，是一种代谢应激性肝损伤，与胰岛素抵抗和遗传易感性密切相关。本文从MAFLD的流行病学特征、发病机制、诊断技术及治疗策略等四个方面的研究进展进行综述，分析当前研究中存在的挑战，梳理未来的研究方向，旨在为MAFLD的基础研究方向与临床诊疗策略提供参考。
Abstract: Metabolic-associated fatty liver disease (MAFLD) is the most prevalent chronic liver disease globally, which is a type of metabolic stress-induced liver injury closely correlated with insulin resistance and genetic susceptibility. This paper reviews the research advances in four aspects, namely the epidemiological characteristics, pathogenesis, diagnostic techniques and therapeutic strategies of MAFLD, analyzes the challenges existing in current research, sorts out the future research directions, and aims to provide references for the basic research directions as well as clinical diagnosis and treatment strategies of MAFLD.
文章引用：兰少宏, 陈晓林. 代谢相关脂肪性肝病的研究进展与展望[J]. 临床医学进展, 2026, 16(2): 2267-2272. https://doi.org/10.12677/acm.2026.162627

参考文献

[1] Eslam, M., Newsome, P.N., Sarin, S.K., Anstee, Q.M., Targher, G., Romero-Gomez, M., et al. (2020) A New Definition for Metabolic Dysfunction-Associated Fatty Liver Disease: An International Expert Consensus Statement. Journal of Hepatology, 73, 202-209. [Google Scholar] [CrossRef] [PubMed]
[2] 中华医学会肝病学分会. 代谢相关(非酒精性)脂肪性肝病防治指南(2024年版) [J]. 中华肝脏病杂志, 2024, 32(5): 418-434.
[3] Rinella, M.E., Lazarus, J.V., Ratziu, V., Francque, S.M., Sanyal, A.J., Kanwal, F., et al. (2023) A Multi-Society Delphi Consensus Statement on New Fatty Liver Disease Nomenclature. Hepatology, 78, 1966-1986. [Google Scholar] [CrossRef] [PubMed]
[4] Younossi, Z.M., Anstee, Q.M., Marietti, M., Hardy, T., Henry, L., Eslam, M., et al. (2017) Global Burden of NAFLD and NASH: Trends, Predictions, Risk Factors and Prevention. Nature Reviews Gastroenterology & Hepatology, 15, 11-20. [Google Scholar] [CrossRef] [PubMed]
[5] Chen, X. and Li, L.H. (2023) Remnant Cholesterol, a Valuable Biomarker for Assessing Arteriosclerosis and Cardiovascular Risk: A Systematic Review. Cureus, 15, e44202. [Google Scholar] [CrossRef] [PubMed]
[6] Ye, Q., Zou, B.Y., Yeo, Y.H., Li, J., Huang, D.Q., Wu, Y., et al. (2020) Global Prevalence, Incidence, and Outcomes of Non-Obese or Lean Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. The Lancet Gastroenterology & Hepatology, 5, 739-752. [Google Scholar] [CrossRef] [PubMed]
[7] Li, J., Zou, B., Yeo, Y.H., Feng, Y., Xie, X., Lee, D.H., et al. (2019) Prevalence, Incidence, and Outcome of Non-Alcoholic Fatty Liver Disease in Asia, 1999-2019: A Systematic Review and Meta-Analysis. The Lancet Gastroenterology & Hepatology, 4, 389-398. [Google Scholar] [CrossRef] [PubMed]
[8] Younossi, Z.M., Golabi, P., Paik, J.M., et al. (2019) The Global Epidemiology of Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH): A Systematic Review. Hepatology, 69, 2023-2034.
[9] Wong, R.J., Aguilar, M. and Loomba, R. (2018) Non-Invasive Assessment of Liver Disease in Non-Alcoholic Fatty Liver Disease: A Position Statement from the American Association for the Study of Liver Diseases. Hepatology, 67, 386-405.
[10] Harrison, S.A., Gawrieh, S., Roberts, K., Lisanti, C.J., Schwope, R.B., Cebe, K.M., et al. (2021) Prospective Evaluation of the Prevalence of Non-Alcoholic Fatty Liver Disease and Steatohepatitis in a Large Middle-Aged US Cohort. Journal of Hepatology, 75, 284-291. [Google Scholar] [CrossRef] [PubMed]
[11] Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., et al. (2024) EASL-EASD-EASO Clinical Practice Guidelines on the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Journal of Hepatology, 81, 492-542. [Google Scholar] [CrossRef] [PubMed]
[12] Sanyal, A.J., Chalasani, N., Kowdley, K.V., et al. (2019) Effect of Obeticholic Acid on Nonalcoholic Steatohepatitis. The New England Journal of Medicine, 380, 1939-1949.

为你推荐