RBM15调控铁死亡在胆管癌治疗中的潜在机制与展望

The Potential Mechanisms and Prospects of RBM15-Mediated Regulation of Ferroptosis in Cholangiocarcinoma Treatment

摘要: RBM15作为关键的RNA结合蛋白，在多种生物学过程中承担核心调控功能，其异常表达与肿瘤发生发展密切相关。近年来，相关研究提示RBM15可能通过调控RNA剪接、表观遗传修饰等参与胆管癌恶性进展，且其与铁死亡这一新型程序性细胞死亡方式的潜在关联已引起关注。然而，目前关于RBM15调控胆管癌细胞铁死亡的直接证据仍较缺乏，现有结论主要基于多领域研究的间接推导。本文作为一篇假说性综述，通过系统梳理RBM15的分子结构与功能特征、胆管癌中的表达模式及铁死亡的分子机制，构建RBM15调控胆管癌细胞铁死亡的潜在假说，旨在为后续针对性验证研究提供理论框架与探索方向。

Abstract: As a key RNA-binding protein, RBM15 plays a central regulatory role in diverse biological processes, and its aberrant expression is closely associated with tumorigenesis and cancer progression. Recent studies suggest that RBM15 may contribute to the malignant progression of cholangiocarcinoma through the regulation of RNA splicing, epigenetic modifications, and related pathways, with emerging evidence highlighting its potential involvement in ferroptosis—a newly recognized form of programmed cell death. However, direct experimental evidence for RBM15-mediated regulation of ferroptosis in cholangiocarcinoma cells remains limited, and current hypotheses are primarily derived from indirect inferences across multiple research fields. As a hypothesis-driven review, this article systematically examines the molecular structure and functional properties of RBM15, its expression profile in cholangiocarcinoma, and the core mechanisms of ferroptosis, proposing a plausible mechanistic link between RBM15 and ferroptosis in cholangiocarcinoma, aiming to provide a theoretical framework and exploratory direction for future targeted validation studies.