SYT7表达水平与非小细胞肺癌临床特征及预后的关系
Relationship between SYT7 Expression and Clinical Characteristics and Prognosis of Non-Small Cell Lung Cancer
摘要: 目的：检测非小细胞肺癌(NSCLC)患者癌组织和外周血中SYT7的表达，并分析SYT7表达水平与非小细胞肺癌的关系。方法：采用免疫组化法(IHC)和酶联免疫吸附法(ELISA)分别检测SYT7在非小细胞肺癌(NSCLC)患者癌组织、癌旁组织以及外周血中的表达情况。结果：免疫组化及酶联免疫吸附法结果证明SYT7在NSCLC患者癌组织及外周血中呈高表达，与肿瘤的直径、淋巴结转移密切相关，且SYT7高表达组的患者PFS和OS均优于低表达组。结论：SYT7或可作为辅助评估患者预后的潜在标志物。
Abstract: Objective: To detect the expression of SYT7 in cancer tissues and peripheral blood of non-small cell lung cancer (NSCLC) patients, and analyze the relationship between SYT7 expression levels and NSCLC. Methods: The expression of SYT7 in NSCLC tissues, adjacent tissues and peripheral blood was detected by immunohistochemistry (IHC) and enzyme-linked immunosorbent assay (ELISA). Results: Immunohistochemical and ELISA results demonstrated that SYT7 was highly expressed in NSCLC patients’ tumor tissues and peripheral blood, which was closely related to tumor diameter and lymph node metastasis. Moreover, patients with high SYT7 expression showed better progression-free survival (PFS) and overall survival (OS) compared to those with low expression. Conclusion: SYT7 may serve as a potential biomarker for auxiliary evaluation of patient prognosis.
文章引用：周雨, 滕根, 李溪, 徐碧澄, 魏婧琦, 彭一楠, 邸文慧, 朱翠敏. SYT7表达水平与非小细胞肺癌临床特征及预后的关系[J]. 临床医学进展, 2026, 16(2): 2494-2502. https://doi.org/10.12677/acm.2026.162655

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