机器人辅助腹腔镜下舌黏膜补片输尿管成形术治疗复杂输尿管狭窄疗效分析
Analysis of the Efficacy of Robot-Assisted Laparoscopic Lingual Mucosal Graft Ureteroplasty for the Treatment of Complex Ureteral Stricture
DOI: 10.12677/acm.2026.162656, PDF,    科研立项经费支持
作者: 张俊志*, 郝宗耀#:安徽医科大学第一附属医院泌尿外科,安徽 合肥
关键词: 输尿管狭窄舌黏膜补片输尿管成形术机器人手术Ureteral Stricture Lingual Mucosal Graft Ureteroplasty Robotic Surgery
摘要: 目的:评估机器人辅助腹腔镜下舌黏膜补片输尿管成形术在治疗复杂输尿管狭窄中的安全性与临床疗效。方法:对2020年5月至2024年12月期间于安徽医科大学第一附属医院泌尿外科接受机器人辅助腹腔镜下舌黏膜补片输尿管成形术治疗输尿管狭窄的12例患者的病例资料进行回顾性分析,记录所纳入病例的手术过程信息、术后并发症及随访资料。其中,3例采用国产精锋手术机器人系统,9例采用进口达芬奇手术机器人系统。结果:12例手术均顺利完成,无中转开放手术,术中无严重并发症发生。两组患者的平均输尿管狭窄长度分别为(3.67 ± 0.58) cm和(4.22 ± 1.30) cm,平均手术时间分别为(359.33 ± 76.38) min和(338.00 ± 117.15) min,平均术中出血量分别为(36.67 ± 15.28) ml和(38.89 ± 19.65) ml,平均术区引流管留置时间分别为(4.33 ± 0.58)天和(4.44 ± 1.24)天,平均术后住院时间分别为6天和(7.00 ± 4.67)天,平均术后导尿管留置时间分别为14天和(12.22 ± 3.03)天。无Clavien-Dindo III级及以上并发症发生,术后2~3个月拔除输尿管支架,术后随访时间均超过12个月,末次随访时所有患者均达到临床成功标准,手术成功率为100%。结论:机器人辅助腹腔镜下舌黏膜补片输尿管成形术治疗复杂输尿管狭窄具有良好的安全性与临床可行性,但仍需通过更大样本研究和延长随访时间进一步验证。
Abstract: Objective: To evaluate the safety and clinical efficacy of robot-assisted laparoscopic lingual mucosal graft ureteroplasty in the treatment of complex ureteral stricture. Methods: A retrospective analysis was conducted on the case records of 12 patients who underwent robot-assisted laparoscopic lingual mucosal graft ureteroplasty for the treatment of ureteral stricture at the Department of Urology, the First Affiliated Hospital of Anhui Medical University from May 2020 to December 2024. The surgical procedure information, postoperative complications, and follow-up data of the included cases were recorded. Among them, 3 cases were treated with a domestic Jingfeng surgical robot system, and 9 cases were treated with an imported Da Vinci surgical robot system. Results: All 12 surgeries were successfully completed without conversion to open surgery, and no severe complications occurred during the operation. The average length of ureteral stricture in the two groups was (3.67 ± 0.58) cm and (4.22 ± 1.30) cm. The average operation time was (359.33 ± 76.38) min and (338.00 ± 117.15) min. The average intraoperative blood loss was (36.67 ± 15.28) ml and (38.89 ± 19.65) ml. The average postoperative drainage tube placement time was (4.33 ± 0.58) days and (4.44 ± 1.24) days. The average postoperative hospital stay was 6 days and (7.00 ± 4.67) days. The average postoperative catheter placement time was 14 days and (12.22 ± 3.03) days. No Clavien-Dindo grade III or higher complications occurred. The ureteral stents were removed 2~3 months postoperatively, and all patients achieved clinical success at the last follow-up, which was over 12 months. The surgical success rate was 100%. Conclusion: Robot-assisted laparoscopic lingual mucosal graft ureteroplasty for the treatment of complex ureteral stricture demonstrates good safety and clinical feasibility, but further verification through larger sample studies and extended follow-up periods is still needed.
文章引用:张俊志, 郝宗耀. 机器人辅助腹腔镜下舌黏膜补片输尿管成形术治疗复杂输尿管狭窄疗效分析[J]. 临床医学进展, 2026, 16(2): 2503-2511. https://doi.org/10.12677/acm.2026.162656

参考文献

[1] 朱照伟, 赵品, 张雪培. 长段输尿管狭窄外科治疗思考: 不同自体组织成形术的优劣及微创与开放的抉择[J]. 现代泌尿外科杂志, 2025, 30(4): 279-283.
[2] 欧阳洁, 张国庆, 邹忠林, 等. 良性输尿管狭窄的诊疗进展[J]. 局解手术学杂志, 2023, 32(12): 1095-1099.
[3] Paffenholz, P. and Heidenreich, A. (2021) Modern Surgical Strategies in the Management of Complex Ureteral Strictures. Current Opinion in Urology, 31, 170-176. [Google Scholar] [CrossRef] [PubMed]
[4] 王建黎. 补片材料在输尿管狭窄修复中的应用[D]: [博士学位论文]. 武汉: 华中科技大学, 2023.
[5] 柴帅帅, 李兵, 肖行远. 自体组织补片修复复杂输尿管狭窄的手术要点及围手术期管理中国专家共识(2024版) [J]. 现代泌尿外科杂志, 2024, 29(5): 388-393.
[6] Lee, Z., Lee, M., Koster, H., Lee, R., Cheng, N., Jun, M., et al. (2021) A Multi-Institutional Experience with Robotic Ureteroplasty with Buccal Mucosa Graft: An Updated Analysis of Intermediate-Term Outcomes. Urology, 147, 306-310. [Google Scholar] [CrossRef] [PubMed]
[7] Yang, K., Fan, S., Wang, J., Yin, L., Li, Z., Xiong, S., et al. (2022) Robotic-Assisted Lingual Mucosal Graft Ureteroplasty for the Repair of Complex Ureteral Strictures: Technique Description and the Medium-Term Outcome. European Urology, 81, 533-540. [Google Scholar] [CrossRef] [PubMed]
[8] Fan, S., Yin, L., Yang, K., Wang, J., Li, X., Xiong, S., et al. (2021) Posteriorly Augmented Anastomotic Ureteroplasty with Lingual Mucosal Onlay Grafts for Long Proximal Ureteral Strictures: 10 Cases of Experience. Journal of Endourology, 35, 192-199. [Google Scholar] [CrossRef] [PubMed]
[9] Xiong, S., Wang, J., Zhu, W., Yang, K., Ding, G., Li, X., et al. (2020) Onlay Repair Technique for the Management of Ureteral Strictures: A Comprehensive Review. BioMed Research International, 2020, Article ID: 6178286. [Google Scholar] [CrossRef] [PubMed]
[10] 蔡林, 李新飞, 程嗣达, 等. 上尿路重建手术: IUPU技术总结[J]. 现代泌尿外科杂志, 2020, 25(6): 468-473.
[11] 秦旭, 李港, 刘译文, 等. 机器人辅助腹腔镜结合吲哚菁绿荧光显影技术在复杂性输尿管狭窄修复重建中的应用[J]. 徐州医科大学学报, 2024, 44(7): 514-519.
[12] 周袁成, 梁超启, 柴帅帅, 等. 双荧光腹腔镜在舌黏膜修复复杂输尿管狭窄手术中的应用[J]. 现代泌尿外科杂志, 2025, 30(3): 227-231.
[13] 包军胜, 范阳, 冯宁翰, 等. 机器人辅助腹腔镜自体组织补片修复输尿管狭窄中国专家共识[J]. 微创泌尿外科杂志, 2024, 13(2): 93-99.
[14] 孙允冀, 刘云, 左世帅, 等. 腹腔镜舌黏膜补片输尿管成形术治疗长段输尿管狭窄[J]. 现代泌尿外科杂志, 2022, 27(8): 662-665+669.
[15] 陈睿龙, 张恺然, 王毅, 等. 口腔黏膜补片在输尿管狭窄重建中的应用效果[J]. 泌尿外科杂志(电子版), 2024, 16(4): 13-17.
[16] Naude, (1999) Buccal Mucosal Grafts in the Treatment of Ureteric Lesions. BJU International, 83, 751-754. [Google Scholar] [CrossRef] [PubMed]
[17] 李兵, 徐玉节, 海波, 等. 腹腔镜舌黏膜输尿管成形术修复输尿管上段狭窄的初步临床应用[J]. 临床泌尿外科杂志, 2015, 30(10): 869-871.
[18] Wang, Y., Jiang, Y., Zhang, Z., Yang, C., Fang, L. and Yu, D. (2023) Laparoscopic Ureteroplasty with Oral Mucosal Graft for Ureteral Stricture: Initial Experience of Eighteen Patients. Asian Journal of Surgery, 46, 751-755. [Google Scholar] [CrossRef] [PubMed]
[19] Zhao, L.C., Weinberg, A.C., Lee, Z., Ferretti, M.J., Koo, H.P., Metro, M.J., et al. (2018) Robotic Ureteral Reconstruction Using Buccal Mucosa Grafts: A Multi-Institutional Experience. European Urology, 73, 419-426. [Google Scholar] [CrossRef] [PubMed]
[20] 方露, 杨超, 王琦, 等. 腹腔镜自体舌黏膜补片输尿管成形术治疗复杂输尿管狭窄的疗效分析[J]. 中国微创外科杂志, 2025, 25(4): 233-237.
[21] 王璐懿, 付宇强, 包军胜, 等. 舌黏膜及颊黏膜治疗输尿管狭窄效果比较的meta分析[J]. 临床泌尿外科杂志, 2024, 39(7): 589-594.
[22] 肖行远, 周辉霞, 王毅, 等. 口腔黏膜补片修复输尿管狭窄的可行性、安全性和疗效[J]. 中华泌尿外科杂志, 2023, 44(2): 121-127.
[23] Liang, C., Wang, J., Hai, B., Xu, Y., Zeng, J., Chai, S., et al. (2022) Lingual Mucosal Graft Ureteroplasty for Long Proximal Ureteral Stricture: 6 Years of Experience with 41 Cases. European Urology, 82, 193-200. [Google Scholar] [CrossRef] [PubMed]
[24] 杨昆霖, 李新飞, 李志华, 等. 机器人输尿管重建手术治疗成人输尿管狭窄的现状[J]. 泌尿外科杂志(电子版), 2023, 15(1): 1-6.
[25] Lucereau, B., Thaveau, F., Lejay, A., Roussin, M., Georg, Y., Heim, F., et al. (2016) Learning Curve of Robotic-Assisted Anastomosis: Shorter than the Laparoscopic Technique? An Educational Study. Annals of Vascular Surgery, 33, 39-44. [Google Scholar] [CrossRef] [PubMed]
[26] 程嗣达, 李新飞, 熊盛炜, 等. 机器人辅助腹腔镜上尿路修复手术: 单一术者108例经验总结[J]. 北京大学学报(医学版), 2020, 52(4): 771-779.
[27] Fan, S., Dai, X., Yang, K., Xiong, S., Xiong, G., Li, Z., et al. (2021) Robot‐Assisted Pyeloplasty Using a New Robotic System, the Kangduo‐Surgical Robot‐01: A Prospective, Single‐Centre, Single‐Arm Clinical Study. BJU International, 128, 162-165. [Google Scholar] [CrossRef] [PubMed]
[28] 董传江, 刘新峰, 许朋, 等. 国产图迈手术机器人用于尿路修复重建手术7例报道[J]. 微创泌尿外科杂志, 2024, 13(2): 133-135.