循环鞘氨醇-1-磷酸作为阻塞性睡眠呼吸暂停 综合征诊断生物标志物的研究
Circulating Sphingosine-1-Phosphate as a Diagnostic Biomarker for Obstructive Sleep Apnea Syndrome
DOI: 10.12677/acm.2026.162674, PDF,    科研立项经费支持
作者: 蔡 湘, 张 超, 王逸群, 马 静, 杨 进*：安徽医科大学第二临床医学院，安徽 合肥；安徽医科大学第二附属医院呼吸与危重症医学科，安徽 合肥
关键词: 阻塞性睡眠呼吸暂停综合征；鞘氨醇-1-磷酸；Epworth嗜睡量表；Obstructive Sleep Apnea Syndrome； Sphingosine-1-Phosphate； Epworth Sleepiness Scale
摘要: 目的：阻塞性睡眠呼吸暂停综合征(OSAS)是重大公共卫生问题，可增加患者代谢性疾病和心血管疾病的发病风险，本研究旨在明确OSAS发病及其严重程度与血清鞘氨醇-1磷酸(S1P)浓度的相关性。方法：纳入111名肥胖受试者，均接受夜间多导睡眠监测(PSG)评估肥胖手术适应症。其中有86例确诊为OSAS患者，25例则作为对照组。采用酶联免疫吸附试验(ELISA)检测血清S1P水平，收集并分析人口统计学及临床相关信息。结果：相较于对照组，OSAS患者的血清S1P水平显著降低；进一步分析可见，OSAS患者群体中，血清S1P水平随病情严重程度的加剧呈逐步下降趋势。线性回归分析结果证实，血清S1P水平与呼吸暂停低通气指数(AHI)存在显著强负相关，而与最低血氧饱和度(LSaO2)则呈明显正相关关系。受试者工作特征(ROC)曲线分析表明，血清S1P在OSAS筛查中的预测效能优于Epworth嗜睡量表(ESS)和STOP评分。结论：相较于对照组，OSAS患者血清S1P水平显著下调，且其水平高低与疾病严重程度呈负相关；同时血清S1P在OSAS诊断中具有良好的特异性、敏感性及阳性预测值，有望成为OSAS的潜在诊断性生物标志物。
Abstract: Objective: Obstructive sleep apnea syndrome (OSAS) is a significant public health issue that increases patients’ risk of developing metabolic and cardiovascular diseases. This study aims to clarify the association between OSAS incidence and severity with serum sphingosine-1-phosphate (S1P) concentrations. Methods: A total of 111 obese subjects were enrolled and underwent overnight polysomnography (PSG) to assess eligibility for bariatric surgery. Among them, 86 were diagnosed with OSAS, while 25 served as the control group. Serum S1P levels were measured using enzyme-linked immunosorbent assay (ELISA), and demographic and clinically relevant information was collected and analyzed. Results: Compared with the control group, serum S1P levels were significantly reduced in OSAS patients. Further analysis revealed that within the OSAS patient cohort, serum S1P levels exhibited a progressive decline with increasing disease severity. Linear regression analysis confirmed a significantly strong negative correlation between serum S1P levels and the apnea-hypopnea index (AHI), while a marked positive correlation was observed with the lowest arterial oxygen saturation (LSaO2). Receiver operating characteristic (ROC) curve analysis indicated that serum S1P demonstrated superior predictive efficacy for OSAS screening compared to the Epworth Sleepiness Scale (ESS) and STOP score. Conclusion: Compared with the control group, serum S1P levels were significantly downregulated in OSAS patients, and their levels showed a negative correlation with disease severity. Simultaneously, serum S1P demonstrated good specificity, sensitivity, and positive predictive value in OSAS diagnosis, suggesting its potential as a diagnostic biomarker for OSAS.
文章引用：蔡湘, 张超, 王逸群, 马静, 杨进. 循环鞘氨醇-1-磷酸作为阻塞性睡眠呼吸暂停 综合征诊断生物标志物的研究[J]. 临床医学进展, 2026, 16(2): 2646-2653. https://doi.org/10.12677/acm.2026.162674

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