难治性鼻窦炎表现的嗜酸性肉芽肿性 多血管炎病例1例
One Case of Eosinophilic Granulomatosis with Polyangiitis Presenting with Difficult-to-Treat rhinosinusitis
DOI: 10.12677/acm.2026.162678, PDF,    科研立项经费支持
作者: 申格格*, 和 溪：云南中医药大学第一临床医学院，云南 昆明；黄春江, 刘 骥, 李治金：云南省中医医院耳鼻喉科，云南 昆明
关键词: 难治性鼻窦炎；嗜酸性肉芽肿性多血管炎；哮喘；嗜酸性粒细胞增多；Difficult-to-Treat Rhinosinusitis； Eosinophilic Granulomatosis with Polyangiitis； Asthma； Eosinophils
摘要: EGPA与DTRS由于都有嗜酸性粒细胞升高与伴发哮喘的特点，但EGPA可累及全身多个系统且缺乏特异性的临床表现，且由于哮喘及鼻、鼻窦病变常在EGPA早期出现，并且较其他全身系统症状早发数年，因此在患者初期就诊时极易漏诊，导致患者病情进一步进展。本篇报道2025年云南省中医医院收治的以难治性慢性鼻窦炎表现的嗜酸性肉芽肿性多血管炎(eosinophilic granulomatosis with polyangiitis, EGPA)的一则病例的诊治，表明慢性鼻窦炎伴有鼻息肉(CRSwNP)、DTRS、EGPA具有很强的相关性，值得我们进一步探索。
Abstract: Both EGPA and DTRS have the characteristics of eosinophilia and asthma, but EGPA can involve multiple systems of the whole body and lacks specific clinical manifestations. Asthma and nasal and paranasal sinus diseases often appear in the early stage of EGPA, which is several years earlier than other systemic symptoms, so it is easy to miss the diagnosis at the initial visit, leading to further progress of the patient’s condition. This paper reports the diagnosis and treatment of a case of eosinophilic granulomatosis with polyangiitis (EGPA) with refractory chronic sinusitis admitted to Yunnan Provincial Hospital of Traditional Chinese Medicine in 2025. It shows that chronic sinusitis with nasal polyps (CRSwNP), DTRS and EGPA have a strong correlation, which deserves our further exploration.
文章引用：申格格, 和溪, 黄春江, 刘骥, 李治金. 难治性鼻窦炎表现的嗜酸性肉芽肿性 多血管炎病例1例[J]. 临床医学进展, 2026, 16(2): 2682-2688. https://doi.org/10.12677/acm.2026.162678

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