胰岛素抵抗代谢评分临床应用进展
Clinical Progress in the Application of the Metabolic Score for Insulin Resistance
摘要: 胰岛素抵抗是心血管疾病的独立危险因素。通过胰岛素抵抗的评估，可以早期预警心血管疾病的发生，并指导制定干预措施。胰岛素敏感性检测方法众多，其中高胰岛素–正葡萄糖钳夹(HEC)技术是检测胰岛素敏感性的金标准，然而该方法操作繁琐、价格昂贵，临床推广受限。为满足临床需求，一些间接评估胰岛素敏感性的方法相继问世，但各有优缺点。其中胰岛素抵抗代谢评分作为一种基于空腹血糖、血脂和体重指数的评估胰岛素敏感性工具，因其便捷、经济且不依赖胰岛素检测的优势，在大型流行病学调查及临床研究中展现出对心血管疾病风险与预后的良好预测价值。本综述拟系统阐述胰岛素抵抗代谢评分临床应用进展。
Abstract: Insulin resistance is an independent risk factor for cardiovascular disease. Assessing insulin resistance enables early warning of cardiovascular disease onset and guides the development of intervention strategies. Numerous methods exist for measuring insulin sensitivity, among which the Hyperinsulinemic Euglycemic Clamp (HEC) technique serves as the gold standard. However, its cumbersome procedure and high cost limit clinical implementation. To address clinical needs, several indirect methods for assessing insulin sensitivity have emerged, each with distinct advantages and limitations. Among these, the Metabolic Score for Insulin Resistance (Mets-IR) stands out as an assessment tool based on fasting blood glucose, lipid profile, and body mass index. Its advantages—convenience, cost-effectiveness, and independence from insulin testing—have demonstrated strong predictive value for cardiovascular disease risk and prognosis in large-scale epidemiological and clinical studies. This review aims to systematically outline the clinical application progress of Mets-IR.
文章引用：陈俊安, 高韬, 曾玉潇, 柯大智. 胰岛素抵抗代谢评分临床应用进展[J]. 临床医学进展, 2026, 16(2): 2728-2734. https://doi.org/10.12677/acm.2026.162684

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