RNA修饰在结直肠癌中的研究进展:从分子 机制到临床转化
Research Progress of RNA Modification in Colorectal Cancer: From Molecular Mechanism to Clinical Translation
DOI: 10.12677/acm.2026.162687, PDF,   
作者: 王延刚, 杨泽旭, 于照祥*:西安医学院第一附属医院普通外科,陕西 西安;田一凡:西安医学院第一附属医院全科医学,陕西 西安
关键词: RNA修饰结直肠癌结直肠癌的发生肿瘤微环境综述RNA Modification Colorectal Cancer The Occurrence of Colorectal Cancer Tumor Microenvironment Review
摘要: 结直肠癌是全球最常见的恶性肿瘤之一,侵袭性强、致死率高。RNA修饰是目前的一个研究热点,其在结直肠癌的恶性生物学中发挥重要调控作用。RNA修饰由一系列书写蛋白、阅读蛋白和擦除蛋白的协同作用动态且可逆地调节。本文就近年来RNA相关修饰在结直肠癌领域的相关研究作一综述,为结直肠癌发病机制及其治疗的研究提供新的方向。
Abstract: Colorectal cancer is one of the most common malignant tumors in the world, with strong invasiveness and high mortality rate. RNA modification is a research hotspot at present, and it plays an important regulatory role in the malignant biology of colorectal cancer. RNA modification is dynamically and reversibly regulated by the synergistic action of a series of writing, reading, and erasing proteins. In this paper, the related research of RNA-related modification in the field of colorectal cancer in recent years is reviewed, which provides a new direction for the research of pathogenesis and treatment of colorectal cancer.
文章引用:王延刚, 杨泽旭, 田一凡, 于照祥. RNA修饰在结直肠癌中的研究进展:从分子 机制到临床转化[J]. 临床医学进展, 2026, 16(2): 2756-2765. https://doi.org/10.12677/acm.2026.162687

参考文献

[1] Lagunas-Rangel, F.A. (2025) METTL3 in Colorectal Cancer: Molecular Insights and Clinical Implications. Molecular Biology Reports, 53, Article No. 98. [Google Scholar] [CrossRef
[2] Jiang, T., Jiang, N., Chen, X. and Xiong, Z. (2025) The Role of NSUN Family Genes in m5C Methylation and Diseases. Biomedicines, 13, Article 2951. [Google Scholar] [CrossRef
[3] Wang, H., Ge, L., Li, J., Zhong, K., Li, S., Ma, N., et al. (2026) NAT10 Triggers Colorectal Cancer Progression via Promoting PPAN-Regulated DNA Damage Repair. Oncogene, 45, 558-576. [Google Scholar] [CrossRef
[4] Zhao, Y., Sun, H., Li, W., Ye, C., Dou, X., Peng, Y., et al. (2025) Pseudouridylation of 7SK by PUS7 Regulates Pol II Transcription Elongation. Nature Communications, 16, Article No. 9595. [Google Scholar] [CrossRef
[5] Yang, Q., Boyer, T.G. and Al-Hendy, A. (2025) Pseudouridine Synthase 7 in Cancer: Functions, Mechanisms, and Therapeutic Potential. Cells, 14, Article 1380. [Google Scholar] [CrossRef
[6] Hu, J., Zhu, S., He, X., Cen, B., Xu, Z., Han, F., et al. (2026) ALKBH5 Enhances Cadmium-Induced Stemness Enrichment and Proliferation of Colon Cancer Cells via m6A-Dependent Regulation of AXIN2 and Activation of Wnt/β-Catenin Signaling. Chemico-Biological Interactions, 425, Article 111905. [Google Scholar] [CrossRef
[7] Niu, F., Ren, Y., Li, Y., Li, Z., Li, Z., Wang, J., et al. (2026) RNA-Binding Protein GIGYF2 Promotes Colorectal Cancer Progression through Activation of the METTL3/SERP1/STAT3 Axis in an m6A-IGF2BP2-Dependent Manner. Biochemical Pharmacology, 243, Article 117446. [Google Scholar] [CrossRef
[8] Lu, Q., Lv, X., Wang, J., Xia, B., Yan, H., Wang, Z., et al. (2025) Methylation-Mediated LncRNA CRAT40 Promotes Colorectal Cancer Progression by Recruiting YBX1 to Initiate Rela Transcription. International Journal of Biological Sciences, 21, 4834-4850. [Google Scholar] [CrossRef] [PubMed]
[9] Li, J., Luo, Q., Lu, M., Lu, C., Xu, C., Ding, J., et al. (2025) METTL16 Promotes Lipid Metabolic Reprogramming and Colorectal Cancer Progression. International Journal of Biological Sciences, 21, 4782-4797. [Google Scholar] [CrossRef] [PubMed]
[10] Wang, J., Dai, X., Liu, H., et al. (2025) HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4. Advanced Science, 2025, e08541.
[11] Xu, J., Zhang, J., Li, R., Chen, S., Duan, C., Ma, X., et al. (2026) FTO-Mediated m6A Demethylation of CSF3 Suppresses Netosis via Downregulation of RLN2 Expression in Colorectal Cancer. Cell Biology and Toxicology, 42, Article No. 4. [Google Scholar] [CrossRef
[12] Zhou, H., Chen, H., Liu, W., Liang, C., Wang, S., Yuan, K., et al. (2025) Targeting of the M6a Eraser ALKBH5 Suppresses Stemness and Chemoresistance of Colorectal Cancer. Nature Communications, 17, Article No. 803. [Google Scholar] [CrossRef
[13] Cheung, H., Chen, H., Chen, D., Zhou, H., Liang, C., Liu, W., et al. (2025) YTHDF1 Targets the Chemotherapy Response by Suppressing NOTCH1-Induced Stemness in Colorectal Cancer. Signal Transduction and Targeted Therapy, 10, Article No. 409. [Google Scholar] [CrossRef
[14] Wen, J., Shen, M., Zhao, H., Liu, L., Hua, Q., Zhao, X., et al. (2025) Deacetylation of ACLY Mediates RNA m6A-Modification of NOXA and Promotes Chemoresistance of Colorectal Cancer. Advanced Science, 12, e03323. [Google Scholar] [CrossRef
[15] Meng, H., Jalal, M., Wang, H., Wang, Y., Feng, Y., Zheng, P., et al. (2026) 17-AAG Promotes the Degradation of HSP90 Client METTL3 to Suppress MYC RNA m6A Modification and Expression in Colorectal Cancer. International Journal of Biological Macromolecules, 337, Article 149421. [Google Scholar] [CrossRef
[16] Zhu, J.F., Guo, D.P., Lv, H.N., et al. (2025) Histone Lactylation‐Mediated Up‐Regulation of IGF2BP2 Enhances Ferroptosis Resistance via Nrf2 in Colorectal Cancer. Clinical and Translational Medicine, 15, e70551. [Google Scholar] [CrossRef
[17] Li, M., Zha, X., Gao, Z., Zhao, Y., Ma, J., Tian, J., et al. (2025) Downregulated Smad3 Signaling Impairs the Maturation of MO-MDSC in Colorectal Cancer. Cell Death & Disease, 16, Article No. 880. [Google Scholar] [CrossRef
[18] Tan, J., Yu, J., Hou, D., Xie, Y., Lai, D., Zheng, F., et al. (2025) Extracellular Vesicle-Packaged circTAX1BP1 from Cancer-Associated Fibroblasts Regulates RNA m6A Modification through Lactylation of VIRMA in Colorectal Cancer Cells. Advanced Science, 12, e14008. [Google Scholar] [CrossRef
[19] Gong, T., Rai, S.K., Zhu, Y., et al. (2025) Integrative Epitranscriptomic and Transcriptomic Characterization in Human Colorectal Cancer. Journal of Advanced Research. (In Press) [Google Scholar] [CrossRef
[20] Wang, Q., Jiang, X., Yuan, Y. and Li, C. (2025) METTL16 Emerges as a Pivotal Epitranscriptomic Regulator, Linking RNA Modification, Tumor Progression, and Immune Modulation. Frontiers in Immunology, 16, Article 1706971. [Google Scholar] [CrossRef
[21] Wang, G., Ma, Q., Zhu, N., Yan, Y., Zhong, C., Hong, X., et al. (2025) Long Non-Coding Rnas Promote Colorectal Cancer Development through Other Epigenetic Modifications. Gastroenterology Report, 13, goaf081. [Google Scholar] [CrossRef
[22] Qian, S., Song, H., Huang, L., Hua, H., Zhang, X., Li, Z., et al. (2025) DNA, RNA, and Histone Methylation Regulation Enzymes and Their Crosstalk in Colorectal Carcinogenesis and Progression: A Review of Molecular Mechanisms, Clinical Implications, and Future Perspectives. Cellular & Molecular Biology Letters, 30, Article No. 142. [Google Scholar] [CrossRef
[23] Cheng, X., Guo, J., Cao, H., Bi, H., Dong, S., Wang, H., et al. (2025) A Highly Sensitive Magnetic Separation-Assisted Electrochemical Sensor for Detection of m6A-MicroRNA-17-5p Based on Rolling Circle Amplification and N3-Kethoxal Labeling Strategy at LIG Electrodes. Analytica Chimica Acta, 1377, Article 344655. [Google Scholar] [CrossRef
[24] Xi, Y., Liu, L., Kim, J., Zhang, M., Wang, X., Abdirassil, A., et al. (2026) Targeting ADAR1-Mediated RNA Editing Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis by Enhancing HSC-Intrinsic Innate Immunity. Gut, 2026, gutjnl-2025-335942. [Google Scholar] [CrossRef
[25] Li, H., Guo, Z., Zou, Y., Zhang, J., Shi, J., Fu, X., et al. (2026) Tumor Extracellular Vesicles LncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A-Dependent hnRNPA2B1/COX-2 Axis. Advanced Science, 2026, e19490. [Google Scholar] [CrossRef
[26] Xi, C., Gao, Y., Jiang, H., Bian, Y., Yu, C., Chen, Z., et al. (2026) The Novel Roles of RNA 5-Methylcytosine Modification in Gastrointestinal Tract Cancers. Critical Reviews in Oncology/Hematology, 219, Article 105140. [Google Scholar] [CrossRef
[27] Lee, K.H., Sears, T.J., Zanetti, M., et al. (2025) NeoPrecis: Enhancing Immunotherapy Response Prediction through Integration of Qualified Immunogenicity and Clonality-Aware Neoantigen Landscapes. [Google Scholar] [CrossRef] [PubMed]
[28] Zecchin, C., Schalkwijk, S., Pouliquen, I.J., et al. (2026) Straight to Phase III: Model-Informed Approach Speeds Depemokimab Clinical Development in Interleukin-5-Driven Diseases. Clinical Pharmacology and Therapeutics. [Google Scholar] [CrossRef
[29] Ingber, D.E. (2026) Challenges and Opportunities for Human Organ Chips in FDA Assessments and Pharma Pipelines. Cell Stem Cell, 33, 176-183. [Google Scholar] [CrossRef
[30] Ni, W., Xu, Y., Zhang, M., Li, Y., Huang, P., Li, Z., et al. (2025) Lipid Deposition Promotes YTHDF3-Mediated m6A Modification of PPARα to Facilitate Liver Metastasis of Colorectal Cancer. Protein & Cell, 2025, pwaf092. [Google Scholar] [CrossRef