新型肺穿刺技术在肺占位性病变诊断中的研究 进展
Research Progress on Novel Lung Biopsy Techniques in the Diagnosis of Pulmonary Space-Occupying Lesions
DOI: 10.12677/acm.2026.162699, PDF,   
作者: 魏世纪:承德医学院研究生学院,河北 承德;邯郸市中心医院肿瘤内二科,河北 邯郸;郭志远*, 付吕平:邯郸市中心医院肿瘤内二科,河北 邯郸
关键词: 肺癌CT引导下的活检经皮肺活检诊断准确性并发症Lung Cancer Computed Tomography-Guided Biopsy Percutaneous Lung Biopsy Diagnostic Accuracy Complications
摘要: 肺癌位居中国癌症发病顺位第一,同时也是癌症首位死因,随着人口增长与人口老龄化趋势加重,未来中国将面临沉重的癌症负担。早发现,早诊断,早治疗能有效降低肺癌患者的死亡率。CT引导的经皮肺穿刺活检由于其对周围型病变的高诊断率被广泛应用于临床。然而其高并发症的发生限制了该技术的进一步应用。本文通过检索、整理文献资料,总结不同肺穿刺引导方法在肺穿刺中的具体应用情况,以指导不同医疗机构合理选择CT引导的经皮肺穿刺活检方法,提高肺癌的早期诊断准确率,降低肺癌穿刺并发症。
Abstract: Lung cancer ranks first in China’s cancer incidence spectrum and is also the leading cause of cancer-related mortality. With population growth and an accelerating trend of population aging, China is projected to face a substantial cancer burden in the future. Early detection, diagnosis, and treatment can effectively reduce the mortality rate of lung cancer patients. CT-guided percutaneous lung biopsy is widely utilized in clinical practice due to its high diagnostic yield for peripheral lesions. However, the high incidence of complications associated with this technique limits its broader application. This article reviews and synthesizes existing literature to summarize the specific applications of various guidance methods in lung biopsy procedures. The findings aim to assist healthcare institutions in rationally selecting CT-guided percutaneous lung biopsy techniques, thereby improving the accuracy of early lung cancer diagnosis and reducing complication rates.
文章引用:魏世纪, 郭志远, 付吕平. 新型肺穿刺技术在肺占位性病变诊断中的研究 进展[J]. 临床医学进展, 2026, 16(2): 2872-2877. https://doi.org/10.12677/acm.2026.162699

参考文献

[1] Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R.L., Soerjomataram, I., et al. (2024) Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 74, 229-263. [Google Scholar] [CrossRef] [PubMed]
[2] 滕熠, 张晓丹, 夏昌发, 等. 中国与全球癌症发病、死亡和患病对比及其预测分析: GLOBOCAN2022数据解读[J]. 中华肿瘤防治杂志, 2024, 31(23): 1413-1420.
[3] Wu, Y., He, S., Cao, M., Teng, Y., Li, Q., Tan, N., et al. (2024) Comparative Analysis of Cancer Statistics in China and the United States in 2024. Chinese Medical Journal, 137, 3093-3100. [Google Scholar] [CrossRef] [PubMed]
[4] 张小艳, 张俊林, 王娴, 等. 肺癌早期筛查研究进展[J]. 健康体检与管理, 2024, 5(3): 250-256, 312.
[5] Balasubramanian, P., Abia-Trujillo, D., Barrios-Ruiz, A., Garza-Salas, A., Koratala, A., Chandra, N.C., et al. (2024) Diagnostic Yield and Safety of Diagnostic Techniques for Pulmonary Lesions: Systematic Review, Meta-Analysis and Network Meta-Analysis. European Respiratory Review, 33, Article ID: 240046. [Google Scholar] [CrossRef] [PubMed]
[6] 崔海燕, 梁振宇, 张达成, 等. 比较纤维支气管镜和经皮肺穿刺活检在肺占位性病变中的诊断价值[J]. 中国临床解剖学杂志, 2014, 32(3): 361-364.
[7] Vachani, A., Zhou, M., Ghosh, S., Zhang, S., Szapary, P., Gaurav, D., et al. (2022) Complications after Transthoracic Needle Biopsy of Pulmonary Nodules: A Population-Level Retrospective Cohort Analysis. Journal of the American College of Radiology, 19, 1121-1129. [Google Scholar] [CrossRef] [PubMed]
[8] 王立学, 董鸿鹏, 白博锋, 等. CT引导下经皮肺穿刺活检对不同大小肺结节的诊断效能及并发症相关因素分析[J]. 放射学实践, 2020, 35(11): 1409-1414.
[9] Hoffman, R.M., Atallah, R.P., Struble, R.D. and Badgett, R.G. (2020) Lung Cancer Screening with Low-Dose CT: A Meta-Analysis. Journal of General Internal Medicine, 35, 3015-3025. [Google Scholar] [CrossRef] [PubMed]
[10] Elshafee, A.S., Karch, A., Ringe, K.I., Shin, H., Raatschen, H., Soliman, N.Y., et al. (2019) Complications of Ct-Guided Lung Biopsy with a Non-Coaxial Semi-Automated 18 Gauge Biopsy System: Frequency, Severity and Risk Factors. PLOS ONE, 14, e0213990. [Google Scholar] [CrossRef] [PubMed]
[11] 王勇, 陈列松, 周钢, 等. 远距离激光引导进针角度装置用于CT引导下经皮肺穿刺活检[J]. 中国介入影像与治疗学, 2021, 18(6): 330-334.
[12] Li, Z., Hu, S., Leng, L., Ding, C., Zhao, J., Ye, L., et al. (2025) Comparison of Laser-Guided Technology and Conventional Manual Percutaneous Lung Biopsy: A Single-Center Retrospective Study. Journal of Thoracic Disease, 17, 1570-1579. [Google Scholar] [CrossRef] [PubMed]
[13] Jeon, M., Kim, J.O., Jung, S.S., Park, H.S., Lee, J.E., Moon, J.Y., et al. (2018) CT-Guided Percutaneous Transthoracic Needle Biopsy Using the Additional Laser Guidance System by a Pulmonologist with 2 Years of Experience in CT-Guided Percutaneous Transthoracic Needle Biopsy. Tuberculosis and Respiratory Diseases, 81, 330-338. [Google Scholar] [CrossRef] [PubMed]
[14] 董建春, 杨纯杰, 薛青青, 等. 双极激光定位导航仪在深部肺结节经皮穿刺活检中的应用[J]. 介入放射学杂志, 2023, 32(10): 1010-1013.
[15] 黄晓媚, 杨清杰, 孙晓雁, 等. 自主研发的三维激光引导装置在经皮肺小结节穿刺中的应用[J]. 中国微创外科杂志, 2019, 19(11): 1027-1031.
[16] Zhang, J., He, J., Chen, J., Zhong, Y., He, J. and Li, S. (2021) Application of Indocyanine Green Injection Guided by Electromagnetic Navigation Bronchoscopy in Localization of Pulmonary Nodules. Translational Lung Cancer Research, 10, 4414-4422. [Google Scholar] [CrossRef] [PubMed]
[17] Taton, O., Bondue, B., Gevenois, P.A., Remmelink, M. and Leduc, D. (2018) Diagnostic Yield of Combined Pulmonary Cryobiopsies and Electromagnetic Navigation in Small Pulmonary Nodules. Pulmonary Medicine, 2018, Article ID: 6032974. [Google Scholar] [CrossRef] [PubMed]
[18] Livi, V., Barisione, E., Zuccatosta, L., Romagnoli, M., Praticò, A., Michieletto, L., et al. (2019) Competence in Navigation and Guided Transbronchial Biopsy for Peripheral Pulmonary Lesions. Panminerva Medica, 61, 280-289. [Google Scholar] [CrossRef] [PubMed]
[19] Yarmus, L.B., Arias, S., Feller-Kopman, D., et al. (2016) Electromagnetic Navigation Transthoracic Needle Aspiration for the Diagnosis of Pulmonary Nodules: A Safety and Feasibility Pilot Study. Journal of Thoracic Disease, 8, 186-194.
[20] Zhang, Y., Huang, H., Cao, S., Teng, J., Wang, Y., Ling, X., et al. (2021) Clinical Value of an Electromagnetic Navigation System for CT-Guided Percutaneous Lung Biopsy of Peripheral Lung Lesions. Journal of Thoracic Disease, 13, 4885-4893. [Google Scholar] [CrossRef] [PubMed]
[21] 曾晖, 章浙伟, 严兴, 等. IG4电磁导航系统辅助CT引导下肺穿刺活检术在肺占位病变诊断中的临床价值[J]. 中华危重症医学杂志(电子版), 2020, 13(4): 264-269.
[22] 吕银章, 郑光, 王南, 等. 电磁导航系统在CT引导下肺结块病变穿刺中的应用价值[J]. 放射学实践, 2018, 33(7): 746-749.
[23] Martelli, N., Serrano, C., van den Brink, H., Pineau, J., Prognon, P., Borget, I., et al. (2016) Advantages and Disadvantages of 3-Dimensional Printing in Surgery: A Systematic Review. Surgery, 159, 1485-1500. [Google Scholar] [CrossRef] [PubMed]
[24] Mounsef, P.J., Aita, R., Skaik, K., Addab, S. and Hamdy, R.C. (2024) Three-Dimensional-Printing-Guided Preoperative Planning of Upper and Lower Extremity Pediatric Orthopedic Surgeries: A Systematic Review of Surgical Outcomes. Journal of Childrens Orthopaedics, 18, 360-371. [Google Scholar] [CrossRef] [PubMed]
[25] Goetstouwers, S., Kempink, D., The, B., Eygendaal, D., van Oirschot, B. and van Bergen, C.J. (2022) Three-Dimensional Printing in Paediatric Orthopaedic Surgery. World Journal of Orthopedics, 13, 1-10. [Google Scholar] [CrossRef] [PubMed]
[26] Kang, W., Zhang, H., Liang, Y., Chen, E., Zhao, J., Gao, Z., et al. (2021) Comparison of Three-Dimensional-Printed Template-Guided and Traditional Implantation of 125I Seeds for Gynecological Tumors: A Dosimetric and Efficacy Study. Journal of Cancer Research and Therapeutics, 17, 688-694. [Google Scholar] [CrossRef] [PubMed]
[27] 王洪波, 曹永军, 杜丽娜. 导航技术和3D打印共面穿刺模板对肺微小结节的诊断价值[J]. 中国防痨杂志, 2024, 46(S1): 97-99.
[28] Wang, H., Ren, T., Chen, P., Luo, G., Wei, N., Tang, Y., et al. (2022) Application of 3-Dimensionally Printed Coplanar Template Improves Diagnostic Yield of CT-Guided Percutaneous Core Needle Biopsy for Pulmonary Nodules. Technology in Cancer Research & Treatment, 21, 1-9. [Google Scholar] [CrossRef] [PubMed]