脓毒症相关心肌损伤代谢失调与免疫调节机制的研究进展
Research Progress on Metabolic Disorders and Immune Regulatory Mechanisms in Sepsis-Induced Myocardial Dysfunction
DOI: 10.12677/acm.2026.162707, PDF,   
作者: 谢冰卿：重庆医科大学第一临床医学院，重庆；陈雪梅*：重庆医科大学附属第一医院重症医学科，重庆
关键词: 脓毒症；心肌损伤；代谢失调；免疫调节；炎症反应；线粒体功能；Sepsis； Myocardial Injury； Metabolic Disorder； Immune Regulation； Inflammatory Response； Mitochondrial Function
摘要: 脓毒症相关心肌损伤(Sepsis-Induced Myocardial Dysfunction, SIMD)是导致脓毒症患者病死率显著升高的关键因素之一。近年来，随着代谢失调与免疫调节机制研究的深入，越来越多的证据表明这两者在SIMD的发病机制中起着核心作用。SIMD中心肌细胞代谢异常表现为能量供应不足、线粒体功能障碍及代谢产物积累，直接影响心肌收缩和舒张功能。同时，免疫细胞的激活及炎症因子的释放通过复杂的信号通路调控心肌炎症反应和细胞损伤。本文综述了脓毒症过程中代谢与免疫调节的相互作用，重点分析了代谢失调如何影响免疫反应，以及免疫调节对心肌代谢状态的反馈作用。结合最新基础和临床研究进展，探讨了代谢与免疫互作机制在SIMD中的具体表现及其潜在治疗靶点，旨在为该领域的深入研究和临床干预提供理论支持和新思路。
Abstract: Sepsis-Induced Myocardial Dysfunction (SIMD) is one of the key factors leading to a significant increase in mortality among sepsis patients. In recent years, with the deepening research into metabolic disorders and immune regulatory mechanisms, an increasing amount of evidence has shown that both play a central role in the pathogenesis of SIMD. The metabolic abnormalities in SIMD cardiomyocytes are characterized by insufficient energy supply, mitochondrial dysfunction, and accumulation of metabolic products, which directly affect myocardial contraction and relaxation functions. At the same time, the activation of immune cells and the release of inflammatory factors regulate myocardial inflammatory responses and cellular damage through complex signaling pathways. This article reviews the interaction between metabolism and immune regulation during the process of sepsis, focusing on how metabolic disorders affect immune responses, as well as the feedback effect of immune regulation on myocardial metabolic status. Combining the latest basic and clinical research progress, it explores the specific manifestations and potential therapeutic targets of the interaction mechanisms between metabolism and immunity in SIMD, aiming to provide theoretical support and new ideas for in-depth research and clinical interventions in this field.
文章引用：谢冰卿, 陈雪梅. 脓毒症相关心肌损伤代谢失调与免疫调节机制的研究进展[J]. 临床医学进展, 2026, 16(2): 2962-2971. https://doi.org/10.12677/acm.2026.162707

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