血清尿酸与高密度脂蛋白胆固醇比值(UHR)与阻塞性睡眠呼吸暂停的相关性

Correlation between Serum Uric Acid to High-Density Lipoprotein Cholesterol Ratio (UHR) and Obstructive Sleep Apnea

摘要: 目的：基于美国国家健康与营养检查调查(NHANES)数据库探讨血清尿酸与高密度脂蛋白胆固醇比值(UHR)与阻塞性睡眠呼吸暂停的关系。方法：本研究利用2005~2008年及2015~2018年开展的美国国家健康和营养检查调查(NHANES)数据，探讨了血清尿酸与高密度脂蛋白胆固醇比值(UHR)与阻塞性睡眠呼吸暂停(OSA)之间的相关性。研究采用经多变量调整的Logistic回归模型分析二者的关系，通过亚组分析探讨其在不同亚组人群的作用。结果：OSA患者的血清尿酸与高密度脂蛋白胆固醇比值显著高于非OSA患者。多变量逻辑回归分析显示，在调整所有变量的模型4中，UHR与OSA之间的正向关联依然存在(OR = 1.81, 95% CI: 1.40~2.35, P < 0.001)。进一步的亚组分析显示，这些关联在“≤49岁”、“无心血管疾病史”的人群中更加显著。结论：本研究揭示了血清尿酸与高密度脂蛋白胆固醇比值(UHR)与阻塞性睡眠呼吸暂停(OSA)发生率之间存在正相关关系，这一发现强调了有必要开展更多研究，以探究这种关联背后的潜在机制及其影响。

Abstract: Objective: To explore the relationship between the serum uric acid to high-density lipoprotein cholesterol ratio (UHR) and obstructive sleep apnea based on the National Health and Nutrition Examination Survey (NHANES) database. Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted during 2005~2008 and 2015~2018 to investigate the correlation between the serum uric acid to high-density lipoprotein cholesterol ratio (UHR) and obstructive sleep apnea (OSA). A multivariate-adjusted Logistic regression model was employed to analyze the relationship between the two indicators, and subgroup analyses were performed to explore the effect of UHR on OSA in different populations. Results: The serum uric acid to high-density lipoprotein cholesterol ratio (UHR) in OSA patients was significantly higher than that in non-OSA patients. Multivariate Logistic regression analysis showed that in Model 4 with all variables adjusted, the positive association between UHR and OSA remained statistically significant (OR = 1.81, 95% CI: 1.40~2.35, P < 0.001). Further subgroup analyses revealed that these associations were more pronounced in the populations of “≤49 years old” and “without a history of cardiovascular diseases”. Conclusion: This study reveals a positive correlation between the serum uric acid to high-density lipoprotein cholesterol ratio (UHR) and the incidence of obstructive sleep apnea (OSA). This finding highlights the necessity of conducting more studies to explore the potential mechanisms underlying this association and its implications.