纳米递送系统，聚焦于亲疏水性中医药
Nanoparticle Delivery System, Focusing on Hydrophilic and Hydrophobic TCM
DOI: 10.12677/acm.2026.162739, PDF,    科研立项经费支持
作者: 王 威, 杜晓明, 段学庆, 陈 福, 李荣光, 李江龙*：眉山市中医医院骨科康复中心，四川 眉山
关键词: 纳米载体；亲水性；疏水性；递送系统；中医药；现代化；Nanocarriers； Hydrophilicity； Hydrophobicity； Delivery Systems； Traditional Chinese Medicine； Modernization
摘要: 目的：传统中医(TCM)在现代医学中占据着关键地位，但其应用常常受到诸如草药成分溶解度低、稳定性差以及生物利用度低等问题的阻碍。为解决这些难题，纳米粒子递送系统应运而生，展现出显著潜力，能够提升中药疗效并减少副作用。本研究旨在全面回顾纳米粒子递送系统在亲水性和疏水性中药成分中的研究与应用情况，旨在评估并优化这些技术，通过将传统医学与前沿纳米技术相结合，推动中药的现代化和国际化进程。方法：为探究纳米粒子递送系统在改善中药成分的物理化学性质方面的应用，进行了全面的文献综述。该研究重点关注了各种纳米载体，包括脂质基、聚合物、无机和杂化纳米粒子，以及它们在递送亲水性和亲脂性中药成分方面的各自优缺点。此外，还分析了具体实例，以说明这些系统如何提高中药的溶解性、稳定性、生物利用度和靶向能力。结果：该综述表明，纳米粒子递送系统有效地解决了中药成分固有的局限性。对于亲水性成分，基于聚合物的纳米乳液系统显著提高了其稳定性，并促进了靶向递送。相反，脂质基和聚合物纳米粒子被发现能显著提高疏水性成分的溶解性和生物利用度。此外，该研究还强调了这些系统通过精确控制药物释放和靶向性来降低毒性并改善治疗效果的潜力。结论：将纳米粒子递送系统与传统中药相结合，为克服传统草药医学面临的挑战提供了一种新颖的方法。通过利用纳米载体的独特特性，我们可以显著提高中药的疗效和安全性，从而为其在现代医学中的更广泛应用铺平道路。这项研究强调了在该领域持续进行研究和创新的重要性，最终目标是实现传统中药在全球医疗保健中的全部潜力。
Abstract: Objective: Traditional Chinese medicine (TCM) holds a pivotal position in the modernization of medicine, yet its application is often hindered by issues such as low solubility, instability, and poor bioavailability of herbal components. To address these challenges, nanoparticle delivery systems have emerged as a promising solution, showcasing significant potential in enhancing the efficacy and reducing side effects of TCM. This study aims to comprehensively review the research and application of nanoparticle delivery systems in both hydrophilic and hydrophobic TCM ingredients, with the objective of assessing and optimizing these technologies to facilitate the modernization and internationalization of TCM by synergizing traditional medicine with cutting-edge nanotechnology. Methods: A thorough literature review was conducted to explore the utilization of nanoparticle delivery systems in improving the physicochemical properties of TCM ingredients. The study focused on various nanocarriers, including lipid-based, polymeric, inorganic, and hybrid nanoparticles, and their respective merits and limitations in delivering hydrophilic and hydrophobic TCM components. Additionally, specific examples were analyzed to illustrate how these systems enhance the solubility, stability, bioavailability, and targeting capabilities of TCM. Results: The review revealed that nanoparticle delivery systems effectively address the inherent limitations of TCM ingredients. For hydrophilic components, polymer-based and nanoemulsion systems significantly improved their stability and facilitated targeted delivery. Conversely, lipid-based and polymeric nanoparticles were found to markedly enhance the solubility and bioavailability of hydrophobic ingredients. Furthermore, the study highlighted the potential of these systems in reducing toxicity and improving therapeutic outcomes through precise control over drug release and targeting. Conclusion: The integration of nanoparticle delivery systems with TCM offers a novel approach to overcoming the traditional challenges associated with herbal medicine. By leveraging the unique properties of nanocarriers, we can significantly enhance the efficacy and safety of TCM, thereby paving the way for its broader application in modern medicine. This study underscores the importance of continuous research and innovation in this field, with the ultimate goal of realizing the full potential of TCM in global healthcare.
文章引用：王威, 杜晓明, 段学庆, 陈福, 李荣光, 李江龙. 纳米递送系统，聚焦于亲疏水性中医药[J]. 临床医学进展, 2026, 16(2): 3263-3273. https://doi.org/10.12677/acm.2026.162739

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