糖酵解重编程介导肿瘤放疗抵抗
Glycolytic Reprogramming Mediated Tumor Radioresistance
DOI: 10.12677/acm.2026.162740, PDF,   
作者: 赖铭楷, 张贵海*：暨南大学珠海临床医学院(珠海市人民医院，北京理工大学附属医院)肿瘤科，广东 珠海
关键词: 糖酵解重编程；Warburg效应；放疗抵抗；放射增敏；Glycolytic Reprogramming； Warburg Effect； Radiotherapy Resistance； Radiosensitization
摘要: 放射治疗是肿瘤治疗的重要手段，但肿瘤细胞可通过糖酵解重编程形成多层次的辐射防御网络，导致放疗抵抗。本综述系统阐述了其核心机制：糖酵解重编程通过增强DNA损伤修复、维持氧化还原稳态、酸化肿瘤微环境并诱导免疫抑制、维持肿瘤干细胞干性与代谢可塑性，以及与细胞周期和自噬等过程交互作用，共同促进肿瘤放疗抵抗。尽管靶向糖酵解在临床前研究中显示出放射增敏潜力，但其临床转化仍面临代谢异质性等挑战。未来需深入解析相关调控网络，发展选择性干预策略，为克服放疗抵抗提供新方向。
Abstract: Radiation therapy is an important means of tumor treatment, but tumor cells can be reprogrammed by glycolysis to form a multi-level radiation defense network, which leads to radiation resistance. This review systematically expounds its core mechanism: glycolytic reprogramming promotes tumor radiotherapy resistance by enhancing DNA damage repair, maintaining redox homeostasis, acidifying tumor microenvironment and inducing immunosuppression, maintaining tumor stem cell dryness and metabolic plasticity, and interacting with cell cycle and autophagy. Although targeted glycolysis shows radiosensitization potential in preclinical research, its clinical transformation still faces challenges such as metabolic heterogeneity. In the future, it is necessary to deeply analyze the relevant regulatory networks and develop selective intervention strategies to provide a new direction for overcoming radiotherapy resistance.
文章引用：赖铭楷, 张贵海. 糖酵解重编程介导肿瘤放疗抵抗[J]. 临床医学进展, 2026, 16(2): 3274-3287. https://doi.org/10.12677/acm.2026.162740

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