血清脑多巴胺神经营养因子水平与急性心肌 梗死严重程度相关性研究
Correlation of Serum CDNF Levels with the Severity of Acute Myocardial Infarction
摘要: 检测急性心肌梗死患者血清中脑多巴胺神经营养因子(Cerebral Dopamine Neurotrophic Factor, CDNF)水平，评估CDNF在急性心肌梗死(Acute myocardial infarction, AMI)严重程度中的价值。纳入2024年9月至2025年8月就诊于青岛大学附属烟台毓璜顶医院心血管内科的急性冠脉综合征(Acute Coronary Syndrome, ACS)患者141例。根据是否诊断为AMI分为AMI组(n = 72)和non-AMI组(n = 69)，收集所有患者入院时血清样本和AMI组患者入院后24 h和96 h血清，通过ELISA法检测血清CDNF的水平，对比AMI组患者与non-AMI组患者入院时CDNF水平。通过Logistic回归和LASSO回归构建诊断模型。分析AMI组患者冠脉病变评分与CDNF水平相关性。研究CDNF水平与AMI患者预后情况相关性。结果：入院AMI组血清CDNF水平高于non-AMI组。多因素Logistic分析显示血清CDNF水平、总胆红素、低密度脂蛋白胆固醇、肌红蛋白是ACS患者发生AMI的独立影响因素。CDNF水平与狭窄冠脉数量、Gensini评分、TIMI血流分级有相关性。不同预后分组患者CDNF水平有差异性，Logistic回归提示CDNF水平与心脏超声结果是患者预后的独立影响因素。结论：CDNF水平对急性心肌梗死的诊断效能、严重程度评估、预后预测有一定意义。
Abstract: To detect serum cerebral dopamine neurotrophic factor (CDNF) levels in patients with acute myocardial infarction (AMI) and evaluate its value in assessing AMI severity. A total of 141 patients with acute coronary syndrome (ACS) admitted to the Department of Cardiology, Affiliated Yantai Yuhuangding Hospital of Qingdao University between September 2024 and August 2025 were enrolled. Patients were divided into an AMI group (n = 72) and a non-AMI group (n = 69). Serum samples were collected from all patients at admission and from AMI patients at 24h and 96h after admission. CDNF levels were measured by ELISA, and levels at admission were compared between the AMI and non-AMI groups. Diagnostic models were constructed using logistic and LASSO regression. The correlation between coronary lesion scores and CDNF levels in AMI patients was analyzed. The association between CDNF levels and prognosis in AMI patients was also investigated. Result: Serum CDNF levels were higher in the AMI group than in the non-AMI group at admission. Multivariate logistic analysis identified serum CDNF, total bilirubin, LDL-C, and myoglobin as independent factors for AMI in ACS patients. CDNF levels correlated with the number of stenosed coronary arteries, Gensini score, and TIMI flow grade. CDNF levels differed among prognostic subgroups, and logistic regression indicated that both CDNF levels and echocardiographic results were independent factors influencing patient prognosis. Conclusion: CDNF levels hold significance for the diagnostic efficacy, severity assessment, and prognosis prediction of acute myocardial infarction.
文章引用：盛勇皓, 任蒙蒙, 董海滨, 王春筱, 龚磊, 仲琳. 血清脑多巴胺神经营养因子水平与急性心肌 梗死严重程度相关性研究[J]. 临床医学进展, 2026, 16(3): 128-143. https://doi.org/10.12677/acm.2026.163771

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