机器学习在术后恶心呕吐预测中的应用及前景
Application and Prospect of Machine Learning in Prediction of Postoperative Nausea and Vomiting
DOI: 10.12677/acm.2026.163790, PDF,   
作者: 付 奎:日照市人民医院麻醉科,山东 日照;邵文擎*:日照市人民医院疼痛科,山东 日照
关键词: 术后恶心呕吐机器学习预测模型风险因素Postoperative Nausea and Vomiting Machine Learning Prediction Model Risk Factors
摘要: 术后恶心呕吐(Postoperative nausea and vomiting, PONV)是围术期常见的并发症,严重影响患者的术后康复,具有重要的临床研究意义。PONV的发生受多种因素影响,包括患者因素、麻醉相关因素、手术相关因素等。本文综述了PONV的发生机制、危险因素,并分析了机器学习在PONV预测中的应用、未来研究方向及潜在影响,为进一步提高PONV管理的准确性和个体化医疗提供了新的思路。
Abstract: Postoperative nausea and vomiting (PONV) is a common perioperative complication, which seriously affects the postoperative rehabilitation of patients, and has important clinical research significance. The occurrence of PONV is affected by many factors, including patient factors, anesthesia-related factors, surgery-related factors. This study reviews the occurrence mechanism and risk factors of PONV, analyzes the application, future research direction and potential impact of machine learning in PONV prediction, which provides a new idea for further improving the accuracy of PONV management and individualized medical treatment.
文章引用:付奎, 邵文擎. 机器学习在术后恶心呕吐预测中的应用及前景[J]. 临床医学进展, 2026, 16(3): 278-283. https://doi.org/10.12677/acm.2026.163790

参考文献

[1] Rajan, N. and Joshi, G.P. (2021) Management of Postoperative Nausea and Vomiting in Adults: Current Controversies. Current Opinion in Anaesthesiology, 34, 695-702. [Google Scholar] [CrossRef] [PubMed]
[2] Gan, T.J., Jin, Z. and Meyer, T.A. (2022) Rescue Treatment of Postoperative Nausea and Vomiting: A Systematic Review of Current Clinical Evidence. Anesthesia & Analgesia, 135, 986-1000. [Google Scholar] [CrossRef] [PubMed]
[3] Daccache, N., Wu, Y., Jeffries, S.D., Zako, J., Harutyunyan, R., Pelletier, E.D., et al. (2025) Safety and Recovery Profile of Patients after Inhalational Anaesthesia versus Target-Controlled or Manual Total Intravenous Anaesthesia: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. British Journal of Anaesthesia, 134, 1474-1485. [Google Scholar] [CrossRef] [PubMed]
[4] Qi, X., Wang, S., Fang, C., Jia, J., Lin, L. and Yuan, T. (2025) Machine Learning and SHAP Value Interpretation for Predicting Comorbidity of Cardiovascular Disease and Cancer with Dietary Antioxidants. Redox Biology, 79, Article ID: 103470. [Google Scholar] [CrossRef] [PubMed]
[5] Zhou, C., Wang, Y., Xue, Q., Yang, J. and Zhu, Y. (2023) Predicting Early Postoperative PONV Using Multiple Machine-Learning-and Deep-Learning-Algorithms. BMC Medical Research Methodology, 23, Article No. 133. [Google Scholar] [CrossRef] [PubMed]
[6] Zhang, K., Jiao, B., Sun, J., Zhang, X., Zhang, G., Li, N., et al. (2025) Predicting High-Risk Factors for Postoperative Inadequate Analgesia and Adverse Reactions in Cesarean Delivery Surgery: A Prospective Study. International Journal of Surgery, 111, 3859-3875. [Google Scholar] [CrossRef] [PubMed]
[7] Gan, T.J., Belani, K.G., Bergese, S., Chung, F., Diemunsch, P., Habib, A.S., et al. (2020) Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting. Anesthesia & Analgesia, 131, 411-448. [Google Scholar] [CrossRef] [PubMed]
[8] Bonnet, M.-., Marret, E., Josserand, J. and Mercier, F.J. (2008) Effect of Prophylactic 5-HT3 Receptor Antagonists on Pruritus Induced by Neuraxial Opioids: A Quantitative Systematic Review. British Journal of Anaesthesia, 101, 311-319. [Google Scholar] [CrossRef] [PubMed]
[9] Horn, C.C., Wallisch, W.J., Homanics, G.E. and Williams, J.P. (2014) Pathophysiological and Neurochemical Mechanisms of Postoperative Nausea and Vomiting. European Journal of Pharmacology, 722, 55-66. [Google Scholar] [CrossRef] [PubMed]
[10] Cascella, M., Guerra, C., Atanasov, A.G., Calevo, M.G., Piazza, O., Vittori, A., et al. (2024) Predicting Post-Surgery Discharge Time in Pediatric Patients Using Machine Learning. Translational Medicine @ UniSa, 26, 69-80. [Google Scholar] [CrossRef] [PubMed]
[11] Salajagheh, S., Kuhestani, S., Sharifzadeh Kermani, M., Taheri, O. and Naeimi Bafghi, N. (2019) Comparison of Ondansetron and Granisetron Effects for Prevention of Nausea and Vomiting Following Strabismus Surgery. Open Access Macedonian Journal of Medical Sciences, 7, 3195-3200. [Google Scholar] [CrossRef] [PubMed]
[12] Weibel, S., Rücker, G., Eberhart, L.H., Pace, N.L., Hartl, H.M., Jordan, O.L., et al. (2020) Drugs for Preventing Postoperative Nausea and Vomiting in Adults after General Anaesthesia: A Network Meta-Analysis. Cochrane Database of Systematic Reviews, No. 10, CD012859. [Google Scholar] [CrossRef] [PubMed]
[13] Yu, T., Han, L., Zhao, J., Fu, J., Fang, P. and Lu, Y. (2025) Effects of Motion Sickness Patch on Postoperative Nausea and Vomiting in Female Patients Undergoing Thyroid Surgery: A Randomized Clinical Trial. International Journal of Surgery, 111, 7001-7009. [Google Scholar] [CrossRef] [PubMed]
[14] Sweeney, B.P. (2002) Why Does Smoking Protect against PONV? British Journal of Anaesthesia, 89, 810-813. [Google Scholar] [CrossRef] [PubMed]
[15] Chin, Y., Wang, W. and Yu, H. (2025) Risk Factors Related to Postoperative Dizziness among Patients Who Underwent General Anesthesia and Intraoperative Analgesics: A Prospective Cohort Study. Journal of PeriAnesthesia Nursing, 40, 365-370. [Google Scholar] [CrossRef] [PubMed]
[16] Sprung, J., Deljou, A., Schroeder, D.R., Warner, D.O. and Weingarten, T.N. (2024) Effect of Propofol Infusion on Need for Rescue Antiemetics in Postanesthesia Care Unit after Volatile Anesthesia: A Retrospective Cohort Study. Anesthesia & Analgesia, 139, 26-34. [Google Scholar] [CrossRef] [PubMed]
[17] Feenstra, M.L., Jansen, S., Eshuis, W.J., van Berge Henegouwen, M.I., Hollmann, M.W. and Hermanides, J. (2023) Opioid-Free Anesthesia: A Systematic Review and Meta-Analysis. Journal of Clinical Anesthesia, 90, Article ID: 111215. [Google Scholar] [CrossRef] [PubMed]
[18] Hristovska, A., Duch, P., Allingstrup, M. and Afshari, A. (2017) Efficacy and Safety of Sugammadex versus Neostigmine in Reversing Neuromuscular Blockade in Adults. Cochrane Database of Systematic Reviews, No. 8, CD012763. [Google Scholar] [CrossRef] [PubMed]
[19] Ishikawa, E., Iwamoto, R., Hojo, T., Teshirogi, T., Hashimoto, K., Shibuya, M., et al. (2022) Cross-Sectional Study of PONV Risk Factors for Oral Surgery after Intubated General Anesthesia with Total Intravenous Anesthesia. Anesthesia Progress, 69, 18-23. [Google Scholar] [CrossRef] [PubMed]
[20] Huang, Q., Wang, F., Liang, C., Huang, Y., Zhao, Y., Liu, C., et al. (2023) Fosaprepitant for Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Gastrointestinal Surgery: A Randomised Trial. British Journal of Anaesthesia, 131, 673-681. [Google Scholar] [CrossRef] [PubMed]
[21] Zhang, H., Jiang, L., Zheng, J. and Li, C. (2025) Supervised Machine Learning-Based Bias Risk of Prognostic Models for Total Knee or Hip Arthroplasty Patients: A Systematic Review. Medicine, 104, e45230. [Google Scholar] [CrossRef
[22] Zhu, Y., Jiang, L., Sun, C., Li, Y. and Xie, H. (2025) A Prediction Model for Postoperative Nausea and Vomiting after Laparoscopic Surgery for Gynecologic Cancers. Clinical Therapeutics, 47, 143-147. [Google Scholar] [CrossRef] [PubMed]
[23] Choi, B., Kim, E., Kim, D.H., Kim, K.M., Bang, J., Noh, G., et al. (2024) Dosing Strategy of Ramosetron to Prevent Postoperative Nausea and Vomiting and Development of Prediction Models Using Data Obtained from Randomized Controlled Trials: A Comparative Study. Clinical Therapeutics, 46, 604-611. [Google Scholar] [CrossRef] [PubMed]
[24] Shan, X., Zhang, M., Liang, Y., Yang, Y., Xiao, X., Chen, R., et al. (2025) Application of Machine Learning to Predict Postoperative Nausea and Vomiting in Laparoscopic Sleeve Gastrectomy. Obesity Surgery, 35, 2663-2672. [Google Scholar] [CrossRef] [PubMed]
[25] Douville, N.J., Bastarache, L., He, J., Wu, K.H., Vanderwerff, B., Bertucci-Richter, E., et al. (2024) Polygenic Score for the Prediction of Postoperative Nausea and Vomiting: A Retrospective Derivation and Validation Cohort Study. Anesthesiology, 142, 52-71. [Google Scholar] [CrossRef] [PubMed]
[26] Xie, M., Deng, Y., Wang, Z., He, Y., Wu, X., Zhang, M., et al. (2023) Development and Assessment of Novel Machine Learning Models to Predict the Probability of Postoperative Nausea and Vomiting for Patient-Controlled Analgesia. Scientific Reports, 13, Article No. 6439. [Google Scholar] [CrossRef] [PubMed]