血清IL-6、IL-8水平对肺癌术后感染预测价值的研究
Review on the Predictive Value of Serum IL-6 and IL-8 Levels for Post-Surgical Infections in Lung Cancer
DOI: 10.12677/acm.2026.163795, PDF,   
作者: 张一帆, 李 旭*：昆明医科大学第二附属医院胸外科，云南 昆明
关键词: IL-6；IL-8；肺癌；术后感染；预测生物标志物；IL-6； IL-8； Lung Cancer； Post-Surgical Infection； Predictive Biomarkers
摘要: 肺癌手术后感染是影响患者预后的常见并发症，血清炎症因子IL-6和IL-8作为潜在的生物标志物，已在多项研究中显示出预测术后感染的潜力。本文综述了IL-6和IL-8在肺癌术后感染中的作用，比较了它们与传统感染标志物的差异，分析了其在临床中的应用前景。研究表明，IL-6和IL-8在术后感染预测中具有较高的敏感性和特异性，尤其在与传统感染标志物联合使用时，能显著提高预测准确性。未来的研究应进一步验证其临床应用价值。
Abstract: Post-surgical infections in lung cancer patients are common complications that significantly affect patient outcomes. Serum inflammatory cytokines IL-6 and IL-8 have been identified as potential biomarkers for predicting post-surgical infections. This review summarizes the role of IL-6 and IL-8 in post-surgical infections following lung cancer surgery, compares them with traditional infection markers, and discusses their clinical application prospects. Studies suggest that IL-6 and IL-8 exhibit high sensitivity and specificity in predicting post-surgical infections, especially when used in combination with traditional infection markers. Future research should further validate their clinical value.
文章引用：张一帆, 李旭. 血清IL-6、IL-8水平对肺癌术后感染预测价值的研究[J]. 临床医学进展, 2026, 16(3): 324-332. https://doi.org/10.12677/acm.2026.163795

参考文献

[1] Aokage, K., Yoshida, J., Hishida, T., Tsuboi, M., Saji, H., Okada, M., et al. (2017) Limited Resection for Early-Stage Non-Small Cell Lung Cancer as Function-Preserving Radical Surgery: A Review. Japanese Journal of Clinical Oncology, 47, 7-11. [Google Scholar] [CrossRef] [PubMed]
[2] Fleszar, M.G., Fortuna, P., Zawadzki, M., Hodurek, P., Bednarz-Misa, I., Witkiewicz, W., et al. (2021) Sex, Type of Surgery, and Surgical Site Infections Are Associated with Perioperative Cortisol in Colorectal Cancer Patients. Journal of Clinical Medicine, 10, 589. [Google Scholar] [CrossRef] [PubMed]
[3] Mustafić, S., Brkić, S., Prnjavorac, B., Sinanović, A., Porobić-Jahić, H. and Salkić, S. (2018) Diagnostic and Prognostic Value of Procalcitonin in Patients with Sepsis. Medicinski Glasnik, 15, 93-100. [Google Scholar] [CrossRef] [PubMed]
[4] Tocu, G., Mihailov, R., Serban, C., Stefanescu, B.I., Tutunaru, D. and Firescu, D. (2023) The Contribution of Procalcitonin, C-Reactive Protein and Interleukin-6 in the Diagnosis and Prognosis of Surgical Sepsis: An Observational and Statistical Study. Journal of Multidisciplinary Healthcare, 16, 2351-2359. [Google Scholar] [CrossRef] [PubMed]
[5] Lim, W., Leung, J.H., Xie, C., Cheng, A.W.T., Su, L., Lum, L., et al. (2024) Circulating Interleukins as Biomarkers in Non-Small Cell Lung Cancer Patients: A Pilot Study Compared to Normal Individuals. Diseases, 12, Article 221. [Google Scholar] [CrossRef] [PubMed]
[6] Liao, C., Yu, Z., Guo, W., Liu, Q., Wu, Y., Li, Y., et al. (2014) Prognostic Value of Circulating Inflammatory Factors in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis. Cancer Biomarkers, 14, 469-481. [Google Scholar] [CrossRef] [PubMed]
[7] Ryan, B.M., Pine, S.R., Chaturvedi, A.K., Caporaso, N. and Harris, C.C. (2014) A Combined Prognostic Serum Interleukin-8 and Interleukin-6 Classifier for Stage 1 Lung Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Journal of Thoracic Oncology, 9, 1494-1503. [Google Scholar] [CrossRef] [PubMed]
[8] Nakamura, T., Procházka, V., Lacina, L., et al. (2020) Postoperative Changes in IL-6 Levels and Their Role in Predicting Infection after Colorectal Surgery. Journal of Surgical Research, 258, 1-9.
[9] Zhang, D., Ren, J., Arafeh, M., Sawyer, R.G., Hu, Q., Wu, X., et al. (2018) The Significance of Interleukin-6 in the Early Detection of Surgical Site Infections after Definitive Operation for Gastrointestinal Fistulae. Surgical Infections, 19, 523-528. [Google Scholar] [CrossRef] [PubMed]
[10] Yamada, T., Hisanaga, M., Nakajima, Y., Kanehiro, H., Watanabe, A., Ohyama, T., et al. (1998) Serum Interleukin-6, Interleukin-8, Hepatocyte Growth Factor, and Nitric Oxide Changes during Thoracic Surgery. World Journal of Surgery, 22, 783-790. [Google Scholar] [CrossRef] [PubMed]
[11] Chang, Y., Huang, W., Yang, S., Jan, C., Nieh, S., Lin, Y., et al. (2024) Interleukin-8/CXCR1 Signaling Contributes to the Progression of Pulmonary Adenocarcinoma Resulting in Malignant Pleural Effusion. Cells, 13, Article 968. [Google Scholar] [CrossRef] [PubMed]
[12] Morjani, O., Yang, Y., Lahlil, R., Lakhiari, H. and Alaoui, H. (2025) Hematological Biomarkers for Early Detection of Lung Cancer: Evaluating the Diagnostic Potential of Circulating Interleukin Levels. International Journal of Molecular Sciences, 26, Article 11014. [Google Scholar] [CrossRef] 
[13] Zheng, X., Lan, H., Hu, Y., et al. (2025) Effect of Interleukin-6 and Interleukin-8 Levels on Pathogenic Bacteria Types in Patients with Advanced Lung Cancer and Pulmonary Infection during Chemotherapy. American Journal of Translational Research, 17, 4723-4732. [Google Scholar] [CrossRef] [PubMed]
[14] Bi, Z.K., Xu, Y., Guo, L., et al. (2024) Effect of Peripheral Blood Inflammatory Indicators on the Efficacy of Immunotherapy in Patients with Advanced Non-Small Cell Lung Cancer and Chronic Obstructive Pulmonary Disease. National Medical Journal of China, 104, 1601-1609.
[15] Yan, X., Han, L., Zhao, R., Fatima, S., Zhao, L. and Gao, F. (2022) Prognosis Value of IL-6, IL-8, and Il-1β in Serum of Patients with Lung Cancer: A Fresh Look at Interleukins as a Biomarker. Heliyon, 8, e09953. [Google Scholar] [CrossRef] [PubMed]
[16] Shiels, M.S., Pfeiffer, R.M., Hildesheim, A., Engels, E.A., Kemp, T.J., Park, J., et al. (2013) Circulating Inflammation Markers and Prospective Risk for Lung Cancer. Journal of the National Cancer Institute, 105, 1871-1880. [Google Scholar] [CrossRef] [PubMed]
[17] Brenner, D.R., Fanidi, A., Grankvist, K., Muller, D.C., Brennan, P., Manjer, J., et al. (2017) Inflammatory Cytokines and Lung Cancer Risk in 3 Prospective Studies. American Journal of Epidemiology, 185, 86-95. [Google Scholar] [CrossRef] [PubMed]
[18] Darif, D., Hammi, I., Kihel, A., El Idrissi Saik, I., Guessous, F. and Akarid, K. (2021) The Pro-Inflammatory Cytokines in COVID-19 Pathogenesis: What Goes Wrong? Microbial Pathogenesis, 153, Article 104799. [Google Scholar] [CrossRef] [PubMed]
[19] Eide, H.A., Halvorsen, A.R., Sandhu, V., Fåne, A., Berg, J., Haakensen, V.D., et al. (2016) Non-Small Cell Lung Cancer Is Characterised by a Distinct Inflammatory Signature in Serum Compared with Chronic Obstructive Pulmonary Disease. Clinical & Translational Immunology, 5, e109. [Google Scholar] [CrossRef] [PubMed]
[20] Huang, Y., Yang, L., Yang, W., Zhou, P., Jiang, Q., Liu, W., et al. (2024) Interleukin-6 on Postoperative Day Three as an Early Predictor of Infections Following Laparoscopic Gastric Cancer Resection. BMC Surgery, 24, Article No. 92. [Google Scholar] [CrossRef] [PubMed]
[21] Corsini, E.M., Wang, Q., Tran, H.T., Mitchell, K.G., Antonoff, M.B., Hofstetter, W.L., et al. (2020) Peripheral Cytokines Are Not Influenced by the Type of Surgical Approach for Non-Small Cell Lung Cancer by Four Weeks Postoperatively. Lung Cancer, 146, 303-309. [Google Scholar] [CrossRef] [PubMed]
[22] Bateman, R.M., Sharpe, M.D., Jagger, J.E., Ellis, C.G., Solé-Violán, J., et al. (2016) Erratum To: 36th International Symposium on Intensive Care and Emergency Medicine. Critical Care, 20, Article No. 347. [Google Scholar] [CrossRef] [PubMed]
[23] 姚燕珍, 方可欣, 鲍舟君, 等. 肺腺癌患者手术前后外周血清细胞因子动态变化研究[J]. 中国卫生检验杂志, 2022, 32(21): 2610-2612.
[24] 张倩, 翟所锴, 张翠华, 等. 血清IL-6和IL-8水平对肺癌术后感染的预测价值[J]. 中华医院感染学杂志, 2024, 34(8): 1187-1190.
[25] Pine, S.R., Mechanic, L.E., Enewold, L., Chaturvedi, A.K., Katki, H.A., Zheng, Y., et al. (2011) Increased Levels of Circulating Interleukin 6, Interleukin 8, C-Reactive Protein, and Risk of Lung Cancer. Journal of the National Cancer Institute, 103, 1112-1122. [Google Scholar] [CrossRef] [PubMed]
[26] Wangsubtawee, S., Thamrongjirapat, T., Trachu, N., Incharoen, P., Jinawath, N., Cheyasawan, P., et al. (2025) The Impact of Systemic Inflammatory Markers on EGFR-Mutant Non-Small Cell Lung Cancer. BMC Cancer, 25, Article No. 1510. [Google Scholar] [CrossRef] 
[27] Gao, J., Ying, Y., Wang, J., Cui, Y. and Zhang, W. (2020) Certain Interleukin Polymorphisms Might Influence Predisposition to Lung Cancer: A Meta-Analysis of 35 Published Studies. IUBMB Life, 72, 957-964. [Google Scholar] [CrossRef] [PubMed]
[28] Patella, M., Anile, M., Del Porto, P., Diso, D., Pecoraro, Y., Onorati, I., et al. (2015) Role of Cytokine Profile in the Differential Diagnosis between Acute Lung Rejection and Pulmonary Infections after Lung Transplantation. European Journal of Cardio-Thoracic Surgery, 47, 1031-1036. [Google Scholar] [CrossRef] [PubMed]
[29] Ding, K., Yi, M., Li, L. and Zhang, Y. (2021) Interleukin Polymorphisms and Protein Levels Associated with Lung Cancer Susceptibility and Phenotypes. Expert Review of Clinical Immunology, 17, 1029-1040. [Google Scholar] [CrossRef] [PubMed]
[30] Song, X., Zhou, S., Xiao, N., Li, Y., Zhen, D., Su, C., et al. (2013) Research on the Relationship between Serum Levels of Inflammatory Cytokines and Non-Small Cell Lung Cancer. Asian Pacific Journal of Cancer Prevention, 14, 4765-4768. [Google Scholar] [CrossRef] [PubMed]
[31] Hofmann, J.N., Yu, K., Bagni, R.K., Lan, Q., Rothman, N. and Purdue, M.P. (2011) Intra-Individual Variability over Time in Serum Cytokine Levels among Participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Cytokine, 56, 145-148. [Google Scholar] [CrossRef] [PubMed]
[32] Kaanane, H., Senhaji, N., Berradi, H., Benchakroun, N., Benider, A., Karkouri, M., et al. (2022) The Influence of Interleukin-6, Interleukin-8, Interleukin-10, Interleukin-17, TNF-A, MIF, STAT3 on Lung Cancer Risk in Moroccan Population. Cytokine, 151, Article 155806. [Google Scholar] [CrossRef] [PubMed]
[33] Zhao, Y., Jia, S., Zhang, K. and Zhang, L. (2023) Serum Cytokine Levels and Other Associated Factors as Possible Immunotherapeutic Targets and Prognostic Indicators for Lung Cancer. Frontiers in Oncology, 13, Article 1064616. [Google Scholar] [CrossRef] [PubMed]
[34] Xie, H., Ruan, G., Wei, L., Deng, L., Zhang, Q., Ge, Y., et al. (2023) The Inflammatory Burden Index Is a Superior Systemic Inflammation Biomarker for the Prognosis of Non-Small Cell Lung Cancer. Journal of Cachexia, Sarcopenia and Muscle, 14, 869-878. [Google Scholar] [CrossRef] [PubMed]
[35] Taylor, M., Evison, M., Michael, S., Obale, E., Fritsch, N.C., Abah, U., et al. (2024) Pre-Operative Measures of Systemic Inflammation Predict Survival after Surgery for Primary Lung Cancer. Clinical Lung Cancer, 25, 460-467.e7. [Google Scholar] [CrossRef] [PubMed]
[36] Millat, M.S., Hasan, M.M., Uddin, M.S., Salam, M.A., Aziz, M.A., Akhter, I., et al. (2025) Inflammatory Cytokines and Specific Factors Influencing Lung Cancer Progression. Cancer Pathogenesis and Therapy, 3, 484-500. [Google Scholar] [CrossRef] 
[37] Vendramini-Costa, D.B. and E. Carvalho, J. (2012) Molecular Link Mechanisms between Inflammation and Cancer. Current Pharmaceutical Design, 18, 3831-3852. [Google Scholar] [CrossRef] [PubMed]
[38] Cavalli, G., Colafrancesco, S., Emmi, G., Imazio, M., Lopalco, G., Maggio, M.C., et al. (2021) Interleukin 1α: A Comprehensive Review on the Role of Il-1α in the Pathogenesis and Treatment of Autoimmune and Inflammatory Diseases. Autoimmunity Reviews, 20, Article 102763. [Google Scholar] [CrossRef] [PubMed]
[39] Fukuyama, T., Ichiki, Y., Yamada, S., Shigematsu, Y., Baba, T., Nagata, Y., et al. (2007) Cytokine Production of Lung Cancer Cell Lines: Correlation between Their Production and the Inflammatory/Immunological Responses Both in Vivo and in Vitro. Cancer Science, 98, 1048-1054. [Google Scholar] [CrossRef] [PubMed]

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