壮族与汉族育龄期多囊卵巢综合征临床表型 对比研究

Clinical Phenotype of Polycystic Ovary Syndrome in the Childbearing Age of Zhuang and Han Nationality Comparative Study

摘要: 目的：多囊卵巢综合征(polycystic ovary syndrome, PCOS)临床表型异质性较大，可因种族和地域环境不同，壮族PCOS的研究较少，通过对比壮族汉族PCOS临床表型为个体化治疗提供参考依据。方法：2019年1月至2022年6月在右江民族医学院附属医院就诊壮族PCOS 231例和汉族PCOS 69例，记录两组的一般资料和临床特征，比较分析壮族汉族PCOS临床表型、内分泌特点等数据。结果：壮族和汉族PCOS临床表型均以A和D型为主，高雄激素占比分别75.8% & 75.4%，胰岛素抵抗占比为55.4% & 59.8%，两组在PCOS临床表型、高雄激素、AMH和HOMA-2R等对比无统计学意义。结论：壮族女性PCOS的临床表型与汉族女性PCOS类似，均以高雄激素和胰岛素抵抗为主要表现。

Abstract: Objective: Polycystic ovary syndrome (PCOS) exhibits significant clinical heterogeneity, which may vary due to differences in race and regional environments. There is limited research on PCOS in the Zhuang population. A comparison of the clinical phenotypes of PCOS between Zhuang and Han populations can provide a reference for individualized treatment. Methods: 231 Zhuang women and 69 Han women diagnosed with PCOS in the affiliated hospital of Youjiang Medical University for Nationalities from January 2019 to June 2022 were included, the clinical classification and characteristics of PCOS were compared. The general information and clinical characteristics of the two groups were recorded, and the clinical phenotype, endocrine characteristics and other data of Zhuang and Han PCOS were compared and analysed. Results: The phenotypes of PCOS in Zhuang and Han women are mainly A and D, with the proportion of PCOS hyper androgen is 75.8% & 75.4% and the proportion of insulin resistance is 55.4% & 59.8%. There was no statistical difference between the two groups in clinical classification, hyper androgen and hirsutism, AMH and HOMA-2R. Conclusion: The clinical classification of PCOS in Zhuang women is similar to that in Han women, with the main manifestations of hyperandrogenism and insulin resistance.