人工智能在中心性浆液性脉络膜视网膜病变中的研究进展
Research Advances of Artificial Intelligence in Central Serous Chorioretinopathy
DOI: 10.12677/acm.2026.163817, PDF,   
作者: 夏玉佳:暨南大学附属爱尔眼科医院,广东 广州;暨南大学附属第一医院,广东 广州;马红婕*:暨南大学附属爱尔眼科医院,广东 广州
关键词: 中心性浆液性脉络膜视网膜病变深度学习光学相干断层扫描多模态影像生物标志物预后预测Central Serous Chorioretinopathy Deep Learning Optical Coherence Tomography Multimodal Imaging Biomarkers Prognostic Prediction
摘要: 中心性浆液性脉络膜视网膜病变(Central Serous Chorioretinopathy, CSC)是常见的致视力损害黄斑疾病,其诊断与治疗监测高度依赖光学相干断层扫描(OCT)及其血管成像(OCTA)等多模态影像。近年来,人工智能(Artificial Intelligence, AI)尤其是深度学习,在医学影像自动分析方面进展迅速,为CSC的筛查、分型与疗效评估提供了新的技术路径。本文系统综述深度学习在CSC自动筛查、病灶分割与量化、疾病分期、疗效预测及预后评估中的研究现状,归纳常用模型、应用场景与验证结果,并讨论其外部验证、可解释性与临床转化等关键挑战,以期为后续研究与临床落地提供参考。
Abstract: Central serous chorioretinopathy (CSC) is a common vision-threatening macular disorder, and its diagnosis and treatment monitoring rely heavily on multimodal imaging, particularly optical coherence tomography (OCT) and OCT angiography (OCTA). In recent years, artificial intelligence, especially deep learning—has advanced rapidly in automated medical image analysis, providing new technical approaches for CSC screening, subtyping, and treatment-response assessment. This review systematically summarizes the current research on deep learning applications in CSC, including automated screening, lesion segmentation and quantification, disease staging, therapeutic response prediction, and prognostic evaluation. We synthesize commonly used models, clinical application scenarios, and validation results, and discuss key challenges such as external validation, model interpretability, and clinical translation, with the aim of informing future research and facilitating real-world implementation.
文章引用:夏玉佳, 马红婕. 人工智能在中心性浆液性脉络膜视网膜病变中的研究进展[J]. 临床医学进展, 2026, 16(3): 507-515. https://doi.org/10.12677/acm.2026.163817

参考文献

[1] Fung, A.T., Yang, Y. and Kam, A.W. (2023) Central Serous Chorioretinopathy: A Review. Clinical & Experimental Ophthalmology, 51, 243-270. [Google Scholar] [CrossRef] [PubMed]
[2] Shojaeinia, M., Hosseini, A., Naderi, M., Baloutch, B., Yekta, M.S., Akbarpour, L., et al. (2025) A Comprehensive Overview: Deep Learning Approaches to Central Serous Chorioretinopathy Diagnosis. BMC Ophthalmology, 25, Article No. 549. [Google Scholar] [CrossRef
[3] Nouri, H., Hasan, N., Abtahi, S.H., et al. (2025) Deep Learning in Central Serous Chorioretinopathy. Survey of Ophthalmology, 71, 718-748.
[4] Zhang, P., Zhang, Q., Hu, X., Chi, W. and Yang, W. (2025) Research Progress in Artificial Intelligence for Central Serous Chorioretinopathy: A Systematic Review. Ophthalmology and Therapy, 14, 2083-2107. [Google Scholar] [CrossRef] [PubMed]
[5] Yoon, J., Han, J., Park, J.I., Hwang, J.S., Han, J.M., Sohn, J., et al. (2020) Optical Coherence Tomography-Based Deep-Learning Model for Detecting Central Serous Chorioretinopathy. Scientific Reports, 10, Article No. 18852. [Google Scholar] [CrossRef] [PubMed]
[6] Han, J., Choi, S., Park, J.I., Hwang, J.S., Han, J.M., Ko, J., et al. (2023) Detecting Macular Disease Based on Optical Coherence Tomography Using a Deep Convolutional Network. Journal of Clinical Medicine, 12, Article 1005. [Google Scholar] [CrossRef] [PubMed]
[7] Yoon, J., Han, J., Ko, J., Choi, S., Park, J.I., Hwang, J.S., et al. (2022) Classifying Central Serous Chorioretinopathy Subtypes with a Deep Neural Network Using Optical Coherence Tomography Images: A Cross-Sectional Study. Scientific Reports, 12, Article No. 422. [Google Scholar] [CrossRef] [PubMed]
[8] Zhang, Z., Deng, C., Duan, J., Wu, S., Lu, S., Chen, T., et al. (2026) The Role of En Face Imaging of Retinal Pigment Epithelium Alterations in Rapid Classification of Central Serous Chorioretinopathy Using Widefield Swept-Source Optical Coherence Tomography. Retina, 46, 373-382. [Google Scholar] [CrossRef
[9] Ko, J., Han, J., Yoon, J., Park, J.I., Hwang, J.S., Han, J.M., et al. (2022) Assessing Central Serous Chorioretinopathy with Deep Learning and Multiple Optical Coherence Tomography Images. Scientific Reports, 12, Article No. 1831. [Google Scholar] [CrossRef] [PubMed]
[10] Jee, D., Yoon, J.H., Ra, H., Kwon, J. and Baek, J. (2022) Predicting Persistent Central Serous Chorioretinopathy Using Multiple Optical Coherence Tomographic Images by Deep Learning. Scientific Reports, 12, Article No. 9335. [Google Scholar] [CrossRef] [PubMed]
[11] Yoon, J., Han, J., Ko, J., Choi, S., Park, J.I., Hwang, J.S., et al. (2023) Developing and Evaluating an AI-Based Computer-Aided Diagnosis System for Retinal Disease: Diagnostic Study for Central Serous Chorioretinopathy. Journal of Medical Internet Research, 25, e48142. [Google Scholar] [CrossRef] [PubMed]
[12] Yoo, T.K., Kim, B.Y., Jeong, H.K., Kim, H.K., Yang, D. and Ryu, I.H. (2022) Simple Code Implementation for Deep Learning-Based Segmentation to Evaluate Central Serous Chorioretinopathy in Fundus Photography. Translational Vision Science & Technology, 11, 22. [Google Scholar] [CrossRef] [PubMed]
[13] Goyanes, E., de Moura, J., Fernández-Vigo, J.I., García-Feijóo, J., Novo, J. and Ortega, M. (2025) 3D Features Fusion for Automated Segmentation of Fluid Regions in CSCR Patients: An OCT-Based Photodynamic Therapy Response Analysis. Journal of Imaging Informatics in Medicine, 38, 476-495. [Google Scholar] [CrossRef] [PubMed]
[14] Ferro Desideri, L., Anguita, R., Berger, L.E., Feenstra, H.M.A., Scandella, D., Sznitman, R., et al. (2024) Analysis of Optical Coherence Tomography Biomarker Probability Detection in Central Serous Chorioretinopathy by Using an Artificial Intelligence-Based Biomarker Detector. International Journal of Retina and Vitreous, 10, Article No. 42. [Google Scholar] [CrossRef] [PubMed]
[15] Ferro Desideri, L., Anguita, R., Berger, L.E., Feenstra, H.M.A., Scandella, D., Sznitman, R., et al. (2024) Baseline Spectral Domain Optical Coherence Tomographic Retinal Layer Features Identified by Artificial Intelligence Predict the Course of Central Serous Chorioretinopathy. Retina, 44, 316-323. [Google Scholar] [CrossRef] [PubMed]
[16] Desideri, L.F., Scandella, D., Berger, L., et al. (2024) Prediction of Chronic Central Serous Chorioretinopathy through Combined Manual Annotation and AI-Assisted Volume Measurement of Flat Irregular Pigment Epithelium. Ophthalmologica, 247, 187-190.
[17] Wei, J., Yu, S., Du, Y., Liu, K., Xu, Y. and Xu, X. (2023) Automatic Segmentation of Hyperreflective Foci in OCT Images Based on Lightweight DBR Network. Journal of Digital Imaging, 36, 1148-1157. [Google Scholar] [CrossRef] [PubMed]
[18] Xu, J., Shen, J., Wan, C., Yan, Z., Zhou, F., Zhang, S., et al. (2023) An Automatic Image Processing Method Based on Artificial Intelligence for Locating the Key Boundary Points in the Central Serous Chorioretinopathy Lesion Area. Computational Intelligence and Neuroscience, 2023, Article 1839387. [Google Scholar] [CrossRef] [PubMed]
[19] Xu, J., Shen, J., Yan, Z., Zhou, F., Wan, C. and Yang, W. (2022) An Intelligent Location Method of Key Boundary Points for Assisting the Diameter Measurement of Central Serous Chorioretinopathy Lesion Area. Computers in Biology and Medicine, 147, Article 105730. [Google Scholar] [CrossRef] [PubMed]
[20] Xu, J., Zhou, F., Shen, J., Yan, Z., Wan, C. and Yao, J. (2024) Automatic Height Measurement of Central Serous Chorioretinopathy Lesion Using a Deep Learning and Adaptive Gradient Threshold Based Cascading Strategy. Computers in Biology and Medicine, 177, Article 108610. [Google Scholar] [CrossRef] [PubMed]
[21] Koidala, S.P., Manne, S.R., Ozimba, K., Rasheed, M.A., Bashar, S.B., Ibrahim, M.N., et al. (2023) Deep Learning Based Diagnostic Quality Assessment of Choroidal OCT Features with Expert-Evaluated Explainability. Scientific Reports, 13, Article No. 1570. [Google Scholar] [CrossRef] [PubMed]
[22] Aoyama, Y., Maruko, I., Kawano, T., Yokoyama, T., Ogawa, Y., Maruko, R., et al. (2021) Diagnosis of Central Serous Chorioretinopathy by Deep Learning Analysis of En Face Images of Choroidal Vasculature: A Pilot Study. PLOS ONE, 16, e0244469. [Google Scholar] [CrossRef] [PubMed]
[23] Lee, K., Ra, H., Lee, J.H., Baek, J. and Lee, W.K. (2021) Classification of Pachychoroid on Optical Coherence Tomographic in Face Images Using Deep Convolutional Neural Networks. Translational Vision Science & Technology, 10, Article 28. [Google Scholar] [CrossRef] [PubMed]
[24] Saito, M., Mitamura, M., Ito, Y., Endo, H., Katsuta, S. and Ishida, S. (2025) A Deep Learning-Based Pachychoroid Index Based on Choroidal Image Patterns of Central Serous Chorioretinopathy Using Enhanced-Depth-Imaging Optical Coherence Tomography. Japanese Journal of Ophthalmology. [Google Scholar] [CrossRef
[25] Mirshahi, R., Naseripour, M., Shojaei, A., Heirani, M., Alemzadeh, S.A., Moodi, F., et al. (2022) Differentiating a Pachychoroid and Healthy Choroid Using an Unsupervised Machine Learning Approach. Scientific Reports, 12, Article No. 16323. [Google Scholar] [CrossRef] [PubMed]
[26] Chen, R., Zhao, Z., Yusufu, M., Shang, X., He, M. and Shi, D. (2025) Choroidal Vascular Fingerprints from Indocyanine Green Angiography Unveil Chorioretinal Disease State. Investigative Ophthalmology & Visual Science, 66, Article No. 3. [Google Scholar] [CrossRef
[27] Kim, I.K., Lee, K., Park, J.H., Baek, J. and Lee, W.K. (2021) Classification of Pachychoroid Disease on Ultrawide-Field Indocyanine Green Angiography Using Auto-Machine Learning Platform. British Journal of Ophthalmology, 105, 856-861. [Google Scholar] [CrossRef] [PubMed]
[28] Maruyama, K., Mei, S., Sakaguchi, H., Hara, C., Miki, A., Mao, Z., et al. (2022) Diagnosis of Choroidal Disease with Deep Learning-Based Image Enhancement and Volumetric Quantification of Optical Coherence Tomography. Translational Vision Science & Technology, 11, Article No. 22. [Google Scholar] [CrossRef] [PubMed]
[29] Seiler, E., Delachaux, L., Cattaneo, J., Garjani, A., Martin, T., Duriez, A., et al. (2024) Importance of OCT-Derived Biomarkers for the Recurrence of Central Serous Chorioretinopathy Using Statistics and Predictive Modelling. Scientific Reports, 14, Article No. 23940. [Google Scholar] [CrossRef] [PubMed]
[30] Pfau, M., van Dijk, E.H.C., van Rijssen, T.J., Schmitz-Valckenberg, S., Holz, F.G., Fleckenstein, M., et al. (2021) Estimation of Current and Post-Treatment Retinal Function in Chronic Central Serous Chorioretinopathy Using Artificial Intelligence. Scientific Reports, 11, Article No. 20446. [Google Scholar] [CrossRef] [PubMed]
[31] Ra, H., Jee, D., Han, S., Lee, S., Kwon, J., Jung, Y., et al. (2025) Prediction of Short-Term Anatomic Prognosis for Central Serous Chorioretinopathy Using a Generative Adversarial Network. Graefes Archive for Clinical and Experimental Ophthalmology, 263, 1523-1531. [Google Scholar] [CrossRef] [PubMed]
[32] Fernández-Vigo, J.I., Gómez Calleja, V., de Moura Ramos, J.J., Novo-Bujan, J., Burgos-Blasco, B., López-Guajardo, L., et al. (2022) Prediction of the Response to Photodynamic Therapy in Patients with Chronic Central Serous Chorioretinopathy Based on Optical Coherence Tomography Using Deep Learning. Photodiagnosis and Photodynamic Therapy, 40, Article 103107. [Google Scholar] [CrossRef] [PubMed]
[33] Yoo, T.K., Kim, S.H., Kim, M., Lee, C.S., Byeon, S.H., Kim, S.S., et al. (2022) DeepPDT-Net: Predicting the Outcome of Photodynamic Therapy for Chronic Central Serous Chorioretinopathy Using Two-Stage Multimodal Transfer Learning. Scientific Reports, 12, Article No. 18689. [Google Scholar] [CrossRef] [PubMed]
[34] Chen, M., Jin, K., You, K., Xu, Y., Wang, Y., Yip, C., et al. (2021) Automatic Detection of Leakage Point in Central Serous Chorioretinopathy of Fundus Fluorescein Angiography Based on Time Sequence Deep Learning. Graefes Archive for Clinical and Experimental Ophthalmology, 259, 2401-2411. [Google Scholar] [CrossRef] [PubMed]
[35] Xu, J., Wan, C., Yang, W., Zheng, B., Yan, Z. and Shen, J. (2021) A Novel Multi-Modal Fundus Image Fusion Method for Guiding the Laser Surgery of Central Serous Chorioretinopathy. Mathematical Biosciences and Engineering, 18, 4797-4816. [Google Scholar] [CrossRef] [PubMed]
[36] Arrigo, A., Calamuneri, A., Aragona, E., Bordato, A., Grazioli Moretti, A., Amato, A., et al. (2021) Structural OCT Parameters Associated with Treatment Response and Macular Neovascularization Onset in Central Serous Chorioretinopathy. Ophthalmology and Therapy, 10, 289-298. [Google Scholar] [CrossRef] [PubMed]
[37] Xu, F., Wan, C., Zhao, L., Liu, S., Hong, J., Xiang, Y., et al. (2021) Predicting Post-Therapeutic Visual Acuity and OCT Images in Patients with Central Serous Chorioretinopathy by Artificial Intelligence. Frontiers in Bioengineering and Biotechnology, 9, Article 649221. [Google Scholar] [CrossRef] [PubMed]
[38] Huynh, E., Chandrasekera, E., Bukowska, D., et al. (2017) Past, Present, and Future Concepts of the Choroidal Scleral Interface Morphology on Optical Coherence Tomography. Asia-Pacific Journal of Ophthalmology, 6, 94-103.
[39] Liu, X., Li, X., Zhang, Y., Wang, M., Yao, J. and Tang, J. (2024) Boundary-Repairing Dual-Path Network for Retinal Layer Segmentation in OCT Image with Pigment Epithelial Detachment. Journal of Imaging Informatics in Medicine, 37, 3101-3130. [Google Scholar] [CrossRef] [PubMed]
[40] Chang-Wolf, J.M., Pauleikhoff, L.J.B., Ruiters, C., Moll, A.C., Schlingemann, R.O., van Dijk, E.H.C., et al. (2025) Choroidal Vascular Hyperpermeability Patterns in Central Serous Chorioretinopathy Correlate with Microperimetry: Certain Study Report 4. Acta Ophthalmologica. [Google Scholar] [CrossRef
[41] Zhang, X., Lim, C.Z.F., Chhablani, J. and Wong, Y.M. (2023) Central Serous Chorioretinopathy: Updates in the Pathogenesis, Diagnosis and Therapeutic Strategies. Eye and Vision, 10, Article No. 33. [Google Scholar] [CrossRef] [PubMed]
[42] Schellevis, R.L., van Dijk, E.H.C., Breukink, M.B., Altay, L., Bakker, B., Koeleman, B.P.C., et al. (2018) Role of the Complement System in Chronic Central Serous Chorioretinopathy. JAMA Ophthalmology, 136, 1128-1136. [Google Scholar] [CrossRef] [PubMed]
[43] Chen, Z.J., Lu, S.Y., Rong, S.S., Ho, M., Ng, D.S., Chen, H., et al. (2021) Genetic Associations of Central Serous Chorioretinopathy: A Systematic Review and Meta-Analysis. British Journal of Ophthalmology, 106, 1542-1548. [Google Scholar] [CrossRef] [PubMed]
[44] Haimovici, R., Rumelt, S. and Melby, J. (2003) Endocrine Abnormalities in Patients with Central Serous Chorioretinopathy. Ophthalmology, 110, 698-703. [Google Scholar] [CrossRef] [PubMed]
[45] Nicholson, B.P., Atchison, E., Idris, A.A. and Bakri, S.J. (2018) Central Serous Chorioretinopathy and Glucocorticoids: An Update on Evidence for Association. Survey of Ophthalmology, 63, 1-8. [Google Scholar] [CrossRef] [PubMed]
[46] Mansour, A.M., Koaik, M., Lima, L.H., Casella, A.M.B., Uwaydat, S.H., Shahin, M., et al. (2017) Physiologic and Psychologic Risk Factors in Central Serous Chorioretinopathy. Ophthalmology Retina, 1, 497-507. [Google Scholar] [CrossRef] [PubMed]
[47] Antaki, F., Chopra, R. and Keane, P.A. (2024) Vision-Language Models for Feature Detection of Macular Diseases on Optical Coherence Tomography. JAMA Ophthalmology, 142, 573-576. [Google Scholar] [CrossRef] [PubMed]