卵巢衰老的研究进展：从机制研究到临床管理
Advances in Ovarian Aging Research: From Mechanistic Insights to Clinical Management
DOI: 10.12677/acm.2026.163818, PDF,    科研立项经费支持
作者: 金一丹*, 冯小文, 周 勇：浙江大学医学院附属妇产科医院，浙江 杭州；吴瑞瑾#：浙江大学医学院附属妇产科医院，浙江 杭州；中华人民共和国浙江省妇女生殖健康重点实验室，浙江 杭州；中华人民共和国浙江省妇产科临床研究中心，浙江 杭州
关键词: 卵巢衰老；氧化应激；生物标志物；个体化治疗；综合管理；Ovarian Aging； Oxidative Stress； Biomarkers； Individualized Treatment； Comprehensive Management
摘要: 卵巢衰老不仅是女性生殖健康领域的核心议题，也是多系统健康变化的重要生物学基础，与生育能力下降，内分泌紊乱及多种慢性疾病风险增加密切相关。随着人口老龄化及生育年龄推迟，卵巢衰老问题日益受到临床关注。本文围绕卵巢衰老的研究进展，从发生机制、高危因素进行系统综述，并重点总结卵巢功能的临床评估方法及其对女性整体健康的多维影响。同时，对现有治疗和干预策略的应用现状与局限性进行归纳分析，并对未来个体化管理和精准干预的发展方向进行展望，以期为卵巢衰老的临床评估与综合管理提供参考。
Abstract: Ovarian aging is a central issue in women’s reproductive health and represents a fundamental biological basis for multisystem health changes. It is closely associated with declining fertility, endocrine dysfunction, and an increased risk of various chronic diseases. With population aging and the trend toward delayed childbearing, ovarian aging has received growing attention in clinical practice. This review systematically summarizes recent advances in ovarian aging, focusing on underlying mechanisms and risk factors. Particular emphasis is placed on clinical approaches for assessing ovarian function and the multidimensional impact of ovarian aging on women’s overall health. In addition, current therapeutic and interventional strategies are reviewed with respect to their clinical applications and limitations, and future directions toward individualized management and precision intervention are discussed, with the aim of providing a reference for the clinical evaluation and comprehensive management of ovarian aging.
文章引用：金一丹, 冯小文, 周勇, 吴瑞瑾. 卵巢衰老的研究进展：从机制研究到临床管理[J]. 临床医学进展, 2026, 16(3): 516-524. https://doi.org/10.12677/acm.2026.163818

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