年龄分层下口腔益生菌抑龋机制整合与应用 优化

Age-Stratified Mechanisms and Application Optimization of Oral Probiotics for Caries Prevention

摘要: 龋病作为全球高发的口腔疾病，其发病机制与口腔微生物群落失调密切相关。近年来，益生菌凭借其独特的生态调节功能，逐渐发展成为一种生态可持续的防龋新策略。通过分析各生命阶段口腔微生态特点、龋病易感因素以及益生菌防治作用等相关研究数据，研究发现益生菌的作用途径与效果存在明显的年龄差异性。进一步提出针对不同年龄群体的益生菌应用优化方案，具体包括菌种选择、给药方案及联合治疗策略，并指出未来应致力于发展个性化干预和新型递送系统，以促进口腔益生菌的精准临床应用。

Abstract: Dental caries is a prevalent oral disease worldwide, and its pathogenesis is closely related to the dysbiosis of the oral microbiome. In recent years, probiotics have emerged as an ecologically sustainable strategy for caries prevention, leveraging their unique ability to regulate the oral microecology. By synthesizing research on age-specific oral microecological profiles, factors influencing caries susceptibility, and the preventive and therapeutic potential of probiotics, this study demonstrates that the mechanisms and efficacy of probiotic interventions exhibit distinct variations across different life stages. Furthermore, it proposes optimized, age-stratified probiotic application strategies covering strain selection, administration protocols, and combination therapies. Future efforts should focus on developing personalized probiotic interventions and advanced delivery systems to enable their precise clinical application in oral healthcare.