牙周炎和胰腺癌关联机制的最新进展
Periodontitis and Pancreatic Cancer: Recent Advances in Mechanisms of Association
DOI: 10.12677/acm.2026.163827, PDF,   
作者: 邓杰琳, 吴泳泓, 王 萍*：重庆医科大学附属第一医院口腔科，重庆
关键词: 牙周炎；胰腺癌；研究进展；口腔菌群；Periodontitis； Pancreatic Cancer； Research Progress； Oral Microbiota
摘要: 牙周炎是一种常见的慢性感染性炎症疾病，不仅会危害口腔健康，还和多种全身性病变存在密切联系。近年来流行病学研究以及机制探讨都揭示，牙周炎跟胰腺癌之间具有显著相关性，这为胰腺癌早期预警、诊断及干预提供了新视角。胰腺癌是恶性程度高且预后极差的肿瘤，其早期诊断面临着比较大的挑战，而且治疗耐受性较强，使得患者五年生存率始终处于较低水平。本文对近十年来牙周炎与胰腺癌关联机制研究成果做系统性梳理，着重分析牙周炎在胰腺癌发生发展过程中的具体作用，并且展望牙周医学在胰腺癌诊疗领域的潜在应用价值。研究目的是为牙周炎相关标志物及牙周治疗应用于胰腺癌早期诊断、预后及治疗策略制定提供创新性思路。
Abstract: Periodontitis is a common chronic inflammatory infection, which not only affects oral health, but also is related to many systemic diseases. In recent years, more and more epidemiological and mechanism studies have found that there is a strong correlation between periodontitis and pancreatic cancer, which provides a new idea for early warning, diagnosis and intervention of pancreatic cancer. Pancreatic cancer is a highly malignant tumor, which is difficult to find and treat in the early stage, so the five-year survival rate of patients is very low. This review systematically summarizes the latest research progress on the mechanism relationship between periodontitis and Pancreative Cancer in recent ten years, paying special attention to the role of periodontitis in the occurrence and development of Pancreative Cancer and the potential application of periodontal medicine in clinical treatment. The purpose is to provide a new perspective for early diagnosis, prognosis evaluation and treatment strategy of pancreatic cancer, and to see if periodontitis can help.
文章引用：邓杰琳, 吴泳泓, 王萍. 牙周炎和胰腺癌关联机制的最新进展[J]. 临床医学进展, 2026, 16(3): 600-608. https://doi.org/10.12677/acm.2026.163827

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