PRG4：一个“多面手”蛋白的研究进展与 未来展望
PRG4: Research Progress and Future Perspectives of a “Versatile” Protein
DOI: 10.12677/acm.2026.163828, PDF,   
作者: 钟浩云, 封 初, 李 莉*：延安大学医学院，陕西 延安；榆林市第一医院呼吸与危重症医学科，陕西 榆林；何 达, 高 隆, 刘春娥：榆林市第一医院呼吸与危重症医学科，陕西 榆林
关键词: 蛋白多糖-4；重组人PRG4；细胞外基质；Toll样受体；Proteoglycan 4； rhPRG4； ECM； TLRs
摘要: 蛋白多糖-4 (proteoglycan 4, PRG4)是由软骨细胞、滑膜成纤维细胞等多种细胞分泌的黏蛋白样糖蛋白，其结构包含黏蛋白样重复序列、somatomedin B样结构域与hemopexin样结构域。PRG4不仅在关节润滑与机械保护中发挥核心作用，还具有调控细胞粘附与迁移、调节炎症反应等多重功能。近年来研究显示，PRG4在慢性阻塞性肺疾病、骨关节炎、心血管疾病、代谢性疾病、风湿免疫疾病及肿瘤等多种病理过程中表达异常，并参与疾病的发生与发展。其在滑液、血清及组织中的水平变化与疾病严重程度相关，提示PRG4具有作为疾病生物标志物的潜力。此外，重组人PRG4 (rhPRG4)在一些实验模型中也展现其治疗潜力。本文将对PRG4的结构、功能及其在多种疾病中的作用机制与研究进展进行系统综述。
Abstract: Proteoglycan 4 (PRG4) is a mucin-like glycoprotein secreted by various cell types, including chondrocytes and synovial fibroblasts. Its structure comprises mucin-like repeat domains, a somatomedin B-like domain, and a hemopexin-like domain. PRG4 not only plays a central role in joint lubrication and mechanical protection but also exhibits multiple functions, such as regulating cell adhesion and migration as well as modulating inflammatory responses. Recent studies have shown that PRG4 is aberrantly expressed in a variety of pathological conditions, including chronic obstructive pulmonary disease, osteoarthritis, cardiovascular diseases, metabolic disorders, tumors, and rheumatic immune diseases, and is involved in their pathogenesis and progression. The alterations in PRG4 levels in synovial fluid, serum, and tissues correlate with disease severity, suggesting its potential as a disease biomarker. Furthermore, recombinant human PRG4 (rhPRG4) has demonstrated therapeutic potential in several experimental models. This article aims to systematically review the structure and functions of PRG4, as well as its mechanisms of action and research progress in various diseases.
文章引用：钟浩云, 封初, 何达, 高隆, 刘春娥, 李莉. PRG4：一个“多面手”蛋白的研究进展与 未来展望[J]. 临床医学进展, 2026, 16(3): 609-617. https://doi.org/10.12677/acm.2026.163828

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