肠道微生物群与结直肠癌：菌群失调特征与 关键分子机制的研究进展
Gut Microbiota and Colorectal Cancer: Research Advances in Dysbiosis Characteristics and Key Molecular Mechanisms
DOI: 10.12677/acm.2026.163877, PDF,   
作者: 李彦亭, 姜 政*：重庆医科大学附属第一医院消化内科，重庆
关键词: 肠道微生物群；结直肠癌；菌群失调；Gut Microbiota； Colorectal Cancer； Dysbiosis
摘要: 结直肠癌是全球高发的消化道恶性肿瘤，其发生发展与肠道微生态失衡存在密切关联。肠道微生物群主要通过其代谢产物调控、免疫炎症激活及直接遗传损伤等机制，改变宿主肠道微环境，影响上皮细胞功能与肠道屏障稳定性，从而参与结直肠癌的发生与发展。本文旨在对肠道微生物群的失调特征及其与结直肠癌相关的关键分子机制进行系统综述，为结直肠癌的早期干预、诊断及治疗提供理论参考。
Abstract: Colorectal cancer (CRC) is a highly prevalent malignant tumor of the digestive tract worldwide, and its development is closely associated with intestinal microecological imbalance. The gut microbiota primarily influences the host intestinal microenvironment through mechanisms such as metabolite regulation, immune-inflammatory activation, and direct genetic damage, thereby altering epithelial cell function and intestinal barrier stability, and participating in the initiation and progression of colorectal cancer. This article aims to systematically review the characteristics of gut microbiota dysbiosis and its key molecular mechanisms related to colorectal cancer, providing theoretical insights for early intervention, diagnosis, and treatment of colorectal cancer.
文章引用：李彦亭, 姜政. 肠道微生物群与结直肠癌：菌群失调特征与 关键分子机制的研究进展[J]. 临床医学进展, 2026, 16(3): 1041-1048. https://doi.org/10.12677/acm.2026.163877

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