进行性核上性麻痹1例并文献复习
Progressive Supranuclear Palsy: A Case Report and Literature Review
摘要: 本文通过对1例进行性核上性麻痹(PSP)患者的临床特征、实验室检查、影像学资料进行回顾分析，结合国内外最新文献报道，对进行性核上性麻痹的临床表现、诊断及治疗方法进行文献复习并总结，从而提高临床工作者对于该病的认知，为PSP的临床诊疗提供参考。
Abstract: Through a retrospective analysis of the clinical features, laboratory examinations, and imaging data of a patient with Progressive Supranuclear Palsy (PSP), combined with the latest domestic and international literature reports, this paper reviews and summarizes the clinical manifestations, diagnosis, and treatment methods of PSP. The aim is to enhance clinicians’ understanding of this disease and provide a reference for the clinical diagnosis and treatment of PSP.
文章引用：刘滢, 雷明盛. 进行性核上性麻痹1例并文献复习[J]. 临床医学进展, 2026, 16(3): 1078-1082. https://doi.org/10.12677/acm.2026.163882

参考文献

[1] Agarwal, S. and Gilbert, R. (2023) Progressive Supranuclear Palsy. StatPearls Publishing.
[2] Dickson, D.W., Ahmed, Z., Algom, A.A., Tsuboi, Y. and Josephs, K.A. (2010) Neuropathology of Variants of Progressive Supranuclear Palsy. Current Opinion in Neurology, 23, 394-400. [Google Scholar] [CrossRef] [PubMed]
[3] Litvan, I., Hauw, J.J., Bartko, J.J., Lantos, P.L., Daniel, S.E., Horoupian, D.S., et al. (1996) Validity and Reliability of the Preliminary NINDS Neuropathologic Criteria for Progressive Supranuclear Palsy and Related Disorders. Journal of Neuropathology and Experimental Neurology, 55, 97-105. [Google Scholar] [CrossRef] [PubMed]
[4] Hauw, J.-J., Daniel, S.E., Dickson, D., Horoupian, D.S., Jellinger, K., Lantos, P.L., et al. (1994) Preliminary NINDS Neuropathologic Criteria for Steele‐Richardson‐Olszewski Syndrome (Progressive Supranuclear Palsy). Neurology, 44, 2015-2019. [Google Scholar] [CrossRef] [PubMed]
[5] Litvan, I. (2004) Update on Progressive Supranuclear Palsy. Current Neurology and Neuroscience Reports, 4, 296-302. [Google Scholar] [CrossRef] [PubMed]
[6] Fukui, T., Lee, E., Hosoda, H. and Okita, K. (2010) Obsessive-Compulsive Behavior as a Symptom of Dementia in Progressive Supranuclear Palsy. Dementia and Geriatric Cognitive Disorders, 30, 179-188. [Google Scholar] [CrossRef] [PubMed]
[7] Baschieri, F., Vitiello, M., Cortelli, P., Calandra-Buonaura, G. and Morgante, F. (2022) Autonomic Dysfunction in Progressive Supranuclear Palsy. Journal of Neurology, 270, 109-129. [Google Scholar] [CrossRef] [PubMed]
[8] Oliveira, M.C.B., Ling, H., Lees, A.J., Holton, J.L., De Pablo-Fernandez, E. and Warner, T.T. (2018) Association of Autonomic Symptoms with Disease Progression and Survival in Progressive Supranuclear Palsy. Journal of Neurology, Neurosurgery & Psychiatry, 90, 555-561. [Google Scholar] [CrossRef] [PubMed]
[9] Golbe, L.I. and Ohman-Strickland, P.A. (2007) A Clinical Rating Scale for Progressive Supranuclear Palsy. Brain, 130, 1552-1565. [Google Scholar] [CrossRef] [PubMed]
[10] Morgan, J.C., Ye, X., Mellor, J.A., Golden, K.J., Zamudio, J., Chiodo, L.A., et al. (2021) Disease Course and Treatment Patterns in Progressive Supranuclear Palsy: A Real-World Study. Journal of the Neurological Sciences, 421, 117293. [Google Scholar] [CrossRef] [PubMed]
[11] Boxer, A.L., Yu, J., Golbe, L.I., Litvan, I., Lang, A.E. and Höglinger, G.U. (2017) Advances in Progressive Supranuclear Palsy: New Diagnostic Criteria, Biomarkers, and Therapeutic Approaches. The Lancet Neurology, 16, 552-563. [Google Scholar] [CrossRef] [PubMed]
[12] Vivash, L., Bertram, K.L., Malpas, C.B., Marotta, C., Harding, I.H., Kolbe, S., et al. (2021) Sodium Selenate as a Disease-Modifying Treatment for Progressive Supranuclear Palsy: Protocol for a Phase 2, Randomised, Double-Blind, Placebo-Controlled Trial. BMJ Open, 11, e055019. [Google Scholar] [CrossRef] [PubMed]
[13] Shoeibi, A., Olfati, N. and Litvan, I. (2018) Preclinical, Phase I, and Phase II Investigational Clinical Trials for Treatment of Progressive Supranuclear Palsy. Expert Opinion on Investigational Drugs, 27, 349-361. [Google Scholar] [CrossRef] [PubMed]
[14] Choi, S.W., Park, K.B., Woo, S.K., Kang, S.K. and Ra, J.C. (2014) Treatment of Progressive Supranuclear Palsy with Autologous Adipose Tissue-Derived Mesenchymal Stem Cells: A Case Report. Journal of Medical Case Reports, 8, Article No. 87. [Google Scholar] [CrossRef] [PubMed]
[15] Li, H., Yuan, F., Du, Y., Pan, T., Wen, W., Li, S., et al. (2021) Umbilical Cord Blood Stem Cells Transplantation in a Patient with Severe Progressive Supranuclear Palsy: A Case Report. Journal of Medical Case Reports, 15, Article No. 574. [Google Scholar] [CrossRef] [PubMed]
[16] O’Sullivan, S.S., Massey, L.A., Williams, D.R., Silveira-Moriyama, L., Kempster, P.A., Holton, J.L., et al. (2008) Clinical Outcomes of Progressive Supranuclear Palsy and Multiple System Atrophy. Brain, 131, 1362-1372. [Google Scholar] [CrossRef] [PubMed]

为你推荐