金锁固精丸的药理作用及临床应用研究进展

Research Progress on the Pharmacological Effects and Clinical Applications of Jinsuo Gujing Pill

摘要: 金锁固精丸源于《医方集解》，是中医补肾固精的代表方剂，全方由沙苑子、芡实、莲须、龙骨、牡蛎组成，具有补肾固精、交通心肾之效。现代研究表明，该方通过多成分、多靶点、多通路机制，发挥调节内分泌、保护肾脏、延缓肾损伤等作用。临床不仅广泛应用于遗精、早泄等男科疾病，亦拓展至糖尿病肾病、慢性肾衰竭等肾系疾病及妇科、儿科下元不固诸症，体现“异病同治”特色。未来研究应聚焦于解析其药效物质基础与作用机制网络，并开展高质量临床研究，同时探索人工智能与多组学等新策略，以推动其精准应用与现代化发展。

Abstract: Jinsuo Gujing Pill, originating from Yifang Jijie, is a representative formula in Traditional Chinese Medicine for tonifying the kidney and consolidating essence. It is composed of Astragali Complanati Semen (Sha Yuan Zi), Euryales Semen (Qian Shi), Stamen nelumbinis (Lian Xu), Mastodi Ossis Fossilia (Long Gu), and Ostreae concha (Mu Li). Its functions are to tonify the kidney, secure essence, and regulate the heart-kidney interaction. Modern studies have shown that this formula exerts its effects through multi-component, multi-target, and multi-pathway mechanisms, including regulating endocrine function, protecting renal tissues, and delaying renal injury. Clinically, it is not only widely used in andrological conditions such as spermatorrhea and premature ejaculation but has also been extended to renal diseases like diabetic nephropathy and chronic renal failure, as well as gynecological and pediatric disorders characterized by instability of the lower energizer. This reflects the TCM principle of “treating different diseases with the same method.” Future research should focus on elucidating its pharmacodynamic material basis and mechanism networks, conducting high-quality clinical studies, and exploring novel strategies such as artificial intelligence and multi-omics integration, so as to promote its precise application and modernization.