原发性牙齿萌出障碍动物模型构建的研究现状
Research Status on the Establishment of Animal Models for Primary Failure of Tooth Eruption
摘要: 原发性牙齿萌出障碍(Primary Failure of Eruption, PFE)是一类导致牙列开HE的罕见病，临床只出现局部症状，无全身表现，主要与牙齿萌出机制异常有关。PFE是一种常染色体显性遗传病，甲状旁腺激素受体1 (Parathyroid Hormone Receptor 1, PTH1R)基因突变是其主要病因，多位学者以不同方式敲除PTH1R基因并构建出几种PFE小鼠动物模型作为研究之用，本文就有关PFE动物模型建模方法、建模思路、特点、局限性以及研究结果进行综合，为PFE致病机制研究提供参考。
Abstract: Primary failure of eruption (PFE) is a rare disorder leading to an anterior open bite, characterized by localized clinical symptoms without systemic manifestations, primarily associated with abnormal tooth eruption mechanisms. As an autosomal dominant genetic disease, the main etiology of PFE is mutation in the parathyroid hormone receptor 1 (PTH1R) gene. Several researchers have developed various PFE mouse models by knocking out the PTH1R gene using different approaches. This review comprehensively summarizes the modeling methods, strategies, features, limitations, and research outcomes of existing PFE animal models, aiming to provide a reference for investigating the pathogenic mechanisms of PFE.
文章引用：乔婧, 孔卫东. 原发性牙齿萌出障碍动物模型构建的研究现状[J]. 临床医学进展, 2026, 16(3): 1201-1208. https://doi.org/10.12677/acm.2026.163896

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