病例报告：一氧化碳中毒迟发性脑病后帕金森综合征1例
A Case Report: Parkinson’s Syndrome Secondary to Delayed Encephalopathy after Acute Carbon Monoxide Poisoning
DOI: 10.12677/acm.2026.163898, PDF,   
作者: 游嘉宁, 曾森翠：暨南大学附属第一医院康复科，广东 广州；牟志伟*：暨南大学附属广州市红十字会医院康复科，广东 广州
关键词: 一氧化碳中毒迟发性脑病；帕金森综合征；苍白球；高压氧；康复治疗；Delayed Encephalopathy after Carbon Monoxide Poisoning (DEACMP)； Parkinsonism； Globus Pallidus； Hyperbaric Oxygen； Rehabilitation
摘要: 目的：探讨一氧化碳中毒迟发性脑病(DEACMP)继发帕金森综合征的临床特征及“药物–高压氧–康复”综合治疗方案的疗效。方法：回顾性分析1例53岁女性DEACMP继发帕金森综合征患者的临床资料。患者表现为认知减退、肌张力增高、静止性震颤及慌张步态。在常规抗帕金森药物及高压氧治疗基础上，联合针对性的康复训练。结果：经2周综合治疗，患者四肢肌张力显著降低，不自主震颤减少，起步困难及慌张步态明显改善，日常生活活动能力提高。随访期间病情稳定。结论：DEACMP继发帕金森综合征具有特征性的苍白球影像学改变；早期介入以神经可塑性为基础的综合康复治疗，配合药物与高压氧，可有效改善患者的运动功能与生活质量。
Abstract: Objective: To investigate the clinical characteristics of Parkinson’s syndrome secondary to delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) and the efficacy of a comprehensive treatment protocol combining “medication-hyperbaric oxygen-rehabilitation”. Methods: A retrospective analysis was conducted on the clinical data of a 53-year-old female patient with Parkinson’s syndrome secondary to DEACMP. The patient presented with cognitive decline, increased muscle tone, resting tremor, and festinating gait. Targeted rehabilitation training was combined with conventional anti-Parkinsonian medication and hyperbaric oxygen therapy. Results: After 2 weeks of comprehensive treatment, the patient’s limb muscle tone decreased significantly, involuntary tremor reduced, difficulty in gait initiation and festinating gait improved markedly, and activities of daily living capacity increased. The condition remained stable during follow-up. Conclusion: Parkinson’s syndrome secondary to DEACMP exhibits characteristic imaging changes in the globus pallidus. Early intervention with comprehensive rehabilitation treatment based on neuroplasticity, combined with medication and hyperbaric oxygen therapy, can effectively improve patients’ motor function and quality of life.
文章引用：游嘉宁, 曾森翠, 牟志伟. 病例报告：一氧化碳中毒迟发性脑病后帕金森综合征1例[J]. 临床医学进展, 2026, 16(3): 1217-1224. https://doi.org/10.12677/acm.2026.163898

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