氟比洛芬酯超前镇痛联合七氟烷吸入麻醉在 普外科腹腔镜胆囊切除术患者中的应用效果

The Effect of Firocoxib Estolate Prophylactic Analgesia Combined with Sevoflurane Inhalation Anesthesia in Patients Undergoing Laparoscopic Cholecystectomy in General Surgery

摘要: 目的：分析普外科腹腔镜胆囊切除术(LC)患者应用氟比洛芬酯超前镇痛联合七氟烷吸入麻醉的效果。方法：选取2024年12月至2025年12月在本院普外科行LC的62例患者，采用随机数字表法分为研究组(n = 31)和基础组(n = 31)。研究组采用氟比洛芬酯超前镇痛联合七氟烷吸入麻醉，基础组仅采用七氟烷吸入麻醉。组间对比麻醉指标、术后疼痛程度、炎性因子。结果：研究组苏醒时间、拔管时间、术中七氟烷用量均少于基础组(P < 0.05)；研究组术后6 h、术后12 h、术后24 h评分均低于基础组(P < 0.05)；研究组炎性因子水平均低于基础组(P < 0.05)。结论：氟比洛芬酯超前镇痛联合七氟烷吸入麻醉能够改善LC患者的麻醉指标，降低术后疼痛程度和炎性因子。

Abstract: Objective: To analyze the effect of preemptive analgesia with flurbiprofen axetil combined with sevoflurane inhalation anesthesia in patients undergoing laparoscopic cholecystectomy (LC) in the general surgery department. Methods: A total of 62 patients who underwent LC in the general surgery department of our hospital from December 2024 to December 2025 were selected and randomly divided into a study group (n = 31) and a control group (n = 31) using a random number table. The study group received preemptive analgesia with flurbiprofen axetil combined with sevoflurane inhalation anesthesia, while the control group received only sevoflurane inhalation anesthesia. Anesthesia indicators, postoperative pain levels, and inflammatory factors were compared between the groups. Results: The study group had shorter awakening time, extubation time, and intraoperative sevoflurane consumption compared to the control group (P < 0.05). The study group also showed lower scores at 6 hours, 12 hours, and 24 hours postoperatively than the control group (P < 0.05). Additionally, the study group exhibited lower levels of inflammatory factors than the control group (P < 0.05). Conclusion: Preemptive analgesia with flurbiprofen axetil combined with sevoflurane inhalation anesthesia can improve anesthesia indicators, reduce postoperative pain levels, and lower inflammatory factors in patients undergoing LC.