基于数据挖掘及网络药理学探析龙江医派代表医家治疗慢性阻塞性肺疾病的用药规律 及作用机制

Based on Data Mining and Network Pharmacology, This Study Explores the Medication Patterns and Mechanism of Action of Representative Physicians of the Longjiang Medical School in Treating Chronic Obstructive Pulmonary Disease

摘要: 目的：基于数据挖掘与网络药理学方法，探究龙江医派代表医家治疗慢性阻塞性肺疾病(COPD)的用药规律及作用机制。方法：收集龙江医派代表医家治疗慢性阻塞性肺疾病的医案，利用中医传承辅助平台(V3.5)进行用药频次分析、性味归经分析、关联规则分析与聚类分析；在此基础上，进一步对核心中药组合进行网络药理学分析。结果：共纳入127首处方、220味中药，高频药物包括茯苓、紫苏、紫菀、清半夏、桔梗等；药性以“温性、苦味、归肺经”为主，功效以“补虚类”“化痰止咳平喘类”“清热类”居多。聚类分析得到核心中药组合“甘草、五味子、黄芪、淫羊藿、党参、紫菀”。针对核心中药组合进行网络药理分析，筛选出活性成分139个、潜在作用靶点214个，PPI网络及富集分析提示核心处方可能通过IL-17信号通路、细胞衰老等途径干预COPD。结论：龙江医派治疗COPD以“温肺化痰、补虚固本”为核心，注重肺脾肾同调，其核心处方具有多成分、多靶点、多通路的作用特点，为寒地COPD的中医药治疗提供了理论依据与用药参考。

Abstract: Objective: Based on data mining and network pharmacology methods, this study aims to explore the medication patterns and mechanism of action of representative physicians of the Longjiang Medical School in treating chronic obstructive pulmonary disease (COPD). Methods: Medical cases of representative physicians of the Longjiang Medical School treating COPD were collected. Medication frequency analysis, taste and nature classification analysis, association rule analysis, and clustering analysis were conducted using the Traditional Chinese Medicine Heritage Support Platform (V3.5). On this basis, network pharmacology analysis of the core traditional Chinese medicine combinations was further carried out. Results: A total of 127 prescriptions and 220 types of traditional Chinese medicines were included. Frequent drugs included Poria cocos, Perilla frutescens, Plumbago zeylanica, Qing Banxia, and Areca catechu. The medicinal properties were mainly “warm, bitter, and belonging to the lung meridian”, and the efficacy was mainly “tonifying deficiency, classifying as cough-relieving, asthma-stopping, and heat-clearing”. Clustering analysis yielded the core traditional Chinese medicine combination “Gancao, Wuniuzi, Huangqi, Liangyanghua, Dangshan, and Plumbago zeylanica”. Network pharmacology analysis of the core traditional Chinese medicine combination identified 139 active components and 214 potential target sites. PPI network and enrichment analysis suggested that the core prescription might intervene in COPD through pathways such as the IL-17 signaling pathway and cellular senescence. Conclusion: The treatment of COPD by the Longjiang Medical School focuses on “warming the lung and resolving phlegm, tonifying deficiency and consolidating the foundation”, emphasizing the coordination of lung, spleen, and kidney. The core prescription has the characteristics of multi-components, multi-targets, and multi-pathways, providing theoretical basis and medication reference for the treatment of COPD in the cold region.