超声评估颈动脉易损斑块及其在缺血性脑卒中风险预测中的研究进展
Research Progress of Ultrasonic Evaluation of Vulnerable Carotid Plaques and Its Application in Risk Prediction of Ischemic Stroke
摘要: 缺血性脑卒中是全球高致残致死性脑血管疾病,颈动脉易损斑块破裂及栓子脱落是其重要致病机制之一。常规二维超声在斑块易损性精准评估方面存在一定局限,而缺血性脑卒中的发生与易损斑块密切相关。近年来,超声技术的快速发展推动颈动脉斑块评估由形态学向功能学和分子学层面拓展。本文综述多种超声新技术在颈动脉易损斑块评估中的研究进展,探讨其临床应用价值与未来发展方向,为缺血性脑卒中的风险评估与精准防控提供参考。
Abstract: Ischemic stroke is a cerebrovascular disease with high rates of disability and mortality worldwide, and the rupture of vulnerable carotid plaques followed by embolus detachment constitutes one of its crucial pathogenic mechanisms. Conventional two-dimensional ultrasound has certain limitations in the accurate assessment of plaque vulnerability, whereas the occurrence of ischemic stroke is closely correlated with vulnerable plaques. In recent years, the rapid advancement of ultrasonic techniques has promoted the shift of carotid plaque assessment from the morphological level to the functional and molecular levels. This article reviews the research progress of various novel ultrasonic technologies in the evaluation of vulnerable carotid plaques, discusses their clinical application value and future development directions, and thereby provides a reference for the risk assessment and precise prevention and control of ischemic stroke.
文章引用:汤晓倩, 孙阳. 超声评估颈动脉易损斑块及其在缺血性脑卒中风险预测中的研究进展[J]. 临床医学进展, 2026, 16(3): 1313-1321. https://doi.org/10.12677/acm.2026.163909

参考文献

[1] 孟文婷, 李东翔, 佟玲. 缺血性脑卒中的治疗研究进展[J]. 中国新药杂志, 2016, 25(10): 1114-1120.
[2] 马力丰, 温德惠, 袁桂莉等. 缺血性脑卒中患者的超微血流显像颈动脉斑块特征分析[J]. 影像科学与光化学, 2022, 40(5): 1304-1307.
[3] Zhou, S., Yan, Y. and Hui, P. (2024) Clinical and Carotid Plaque Features in Symptomatic and Asymptomatic Ischemic Stroke. British Journal of Hospital Medicine, 85, 1-13. [Google Scholar] [CrossRef] [PubMed]
[4] 毕瀚文, 刘真. 颈动脉易损斑块的多模态超声评估现状及展望[J]. 中国中西医结合影像学杂志, 2024, 22(2): 227-231.
[5] Kashiwazaki, D., Yamamoto, S., Akioka, N., Hori, E., Shibata, T., Kuwayama, N., et al. (2021) Dilated Microvessel with Endothelial Cell Proliferation Involves Intraplaque Hemorrhage in Unstable Carotid Plaque. Acta Neurochirurgica, 163, 1777-1785. [Google Scholar] [CrossRef] [PubMed]
[6] Mathiesen, E.B., Johnsen, S.H., Wilsgaard, T., Bønaa, K.H., et al. (2011) Carotid Plaque Area and Intima-Media Thickness in Prediction of First-Ever Ischemic Stroke: A 10-Year Follow-Up of 6584 Men and Women: The Tromsø Study. Stroke, 42, 972-978.
[7] 中国医师协会超声医师分会. 超声评价颈动脉易损斑块中国专家共识(2023版) [J]. 中华超声影像学杂志, 2023, 32(8): 645-655.
[8] Prabhakaran, S., Rundek, T., Ramas, R., et al. (2006) Carotid Plaque Surface Irregularity Predicts Ischemic Stroke: The Northern Manhattan Study. Stroke, 37, 2696-2701.
[9] Gupta, A., Kesavabhotla, K., Baradaran, H., et al. (2015) Plaque Echolucency and Stroke Risk in Asymptomatic Carotid Stenosis: A Systematic Review and Meta-Analysis. Stroke, 46, 91-97.
[10] 马春燕, 黄品同, 张巍, 等. 洞察血管, 见微知著: 颈动脉超声临床应用进展[J]. 中国医学影像技术, 2025, 41(8): 1308-1312.
[11] Landry, A., Spence, J.D. and Fenster, A. (2005) Quantification of Carotid Plaque Volume Measurements Using 3D Ultrasound Imaging. Ultrasound in Medicine & Biology, 31, 751-762. [Google Scholar] [CrossRef] [PubMed]
[12] 邢海英, 陈玉辉, 许珂等. 三维超声血管斑块定量分析技术评估颈动脉粥样硬化斑块[J]. 北京大学学报(医学版), 2022, 54(5): 991-999.
[13] van Engelen, A., Wannarong, T., Parraga, G., Niessen, W.J., Fenster, A., Spence, J.D., et al. (2014) Three-Dimensional Carotid Ultrasound Plaque Texture Predicts Vascular Events. Stroke, 45, 2695-2701. [Google Scholar] [CrossRef] [PubMed]
[14] Zhang, Y., Cao, J., Zhou, J., Zhang, C., Li, Q., Chen, S., et al. (2021) Plaque Elasticity and Intraplaque Neovascularisation on Carotid Artery Ultrasound: A Comparative Histological Study. European Journal of Vascular and Endovascular Surgery, 62, 358-366. [Google Scholar] [CrossRef] [PubMed]
[15] Drivelegka, P., Forsblad-d’Elia, H., Angerås, O., Bergström, G., Schmidt, C., Jacobsson, L.T.H., et al. (2020) Association between Serum Level of Urate and Subclinical Atherosclerosis: Results from the SCAPIS Pilot. Arthritis Research & Therapy, 22, Article No. 37. [Google Scholar] [CrossRef] [PubMed]
[16] 中国医师协会超声医师分会. 中国超声造影临床应用指南[M]. 北京: 人民军医出版社, 2017: 64-66.
[17] Li, C., He, W., Guo, D., Chen, L., Jin, X., Wang, W., et al. (2014) Quantification of Carotid Plaque Neovascularization Using Contrast-Enhanced Ultrasound with Histopathologic Validation. Ultrasound in Medicine & Biology, 40, 1827-1833. [Google Scholar] [CrossRef] [PubMed]
[18] 王学椒, 崔立刚. 超声造影及超声弹性成像评估颈动脉斑块易损性应用进展[J]. 中华医学超声杂志(电子版), 2020, 17(9): 911-913.
[19] Baud, J.M., Stanciu, D., Yeung, J., Maurizot, A., Chabay, S., de Malherbe, M., et al. (2021) Contrast Enhanced Ultrasound of Carotid Plaque in Acute Ischemic Stroke (CUSCAS Study). Revue Neurologique, 177, 115-123. [Google Scholar] [CrossRef] [PubMed]
[20] Sun, X., Niu, H., Pei, Y., Wang, X. and Chen, M. (2025) Development and Validation of a Prediction Model for Acute Ischemic Stroke Based on a Novel Ultrasound-Based Carotid Plaque Scoring System and Clinical Factors. Journal of Clinical Ultrasound, 54, 322-333. [Google Scholar] [CrossRef
[21] Xie, X., Bai, Z.Y., Liu, Y. and Zhang, H.B. (2018) Value of Superb Micro-Vascular Imaging in Diagnosing Carotid Artery Vulnerable Plaque. Acta Academiae Medicinae Sinicae, 40, 444-449.
[22] Zamani, M., Skagen, K., Scott, H., Lindberg, B., Russell, D. and Skjelland, M. (2019) Carotid Plaque Neovascularization Detected with Superb Microvascular Imaging Ultrasound without Using Contrast Media. Stroke, 50, 3121-3127. [Google Scholar] [CrossRef] [PubMed]
[23] 魏小雨, 杨力, 王雪, 等. SMI和超声造影在颈动脉斑块内新生血管的比较分析[J]. 中国超声医学杂志, 2018, 34(4): 307-309.
[24] Cheng, L., Zheng, S., Zhang, J., Wang, F., Liu, X., Zhang, L., et al. (2023) Multimodal Ultrasound-Based Carotid Plaque Risk Biomarkers Predict Poor Functional Outcome in Patients with Ischemic Stroke or TIA. BMC Neurology, 23, Article No. 13. [Google Scholar] [CrossRef] [PubMed]
[25] Jin, X., Yang, X. and Li, F. (2025) Prediction of Ischemic Stroke in Elderly Hypertensive Patients Using Carotid Plaque Superb Microvascular Imaging Characteristics: A Lasso-Logistic Regression Model. Journal of Medical Ultrasonics, 52, 227-235. [Google Scholar] [CrossRef] [PubMed]
[26] 王艳红, 钱林学, 胡向东, 马棣, 梁思. 剪切波弹性成像技术评估颈动脉斑块硬度[J]. 临床和实验医学杂志, 2015, 14(4): 327-330.
[27] Pitros, C.F., Manaki, V., Kakisis, J.D. and Kakkos, S.K. (2025) The Role of Shear Wave Elastography in the Assessment of Carotid Plaque Vulnerability: A Systematic Review and Meta-Analysis. International Angiology, 44, 415-425. [Google Scholar] [CrossRef
[28] 杨淑丽, 戴安群, 王盈溢. 剪切波弹性成像联合甘油三酯-葡萄糖指数对颈动脉粥样硬化斑块易损性的诊断效能[J]. 中国超声医学杂志, 2025, 41(8): 854-857.
[29] Zhang, L., Jia, C., Gu, S., Chen, J. and Wu, R. (2024) Intraplaque Neovascularization Combined with Plaque Elasticity for Predicting Ipsilateral Stroke in Patients with Asymptomatic Mild Carotid Stenosis. Quantitative Imaging in Medicine and Surgery, 14, 4815-4824. [Google Scholar] [CrossRef] [PubMed]
[30] Habib, A.H., Baz, A.A., Mohamed, S.F. and Al-Azayem, S.A. (2025) Diagnostic Value of Ultrasound and Shear Wave Elastography in Carotid Plaque Risk Stratification. Journal of Ultrasound, 28, 691-700. [Google Scholar] [CrossRef] [PubMed]
[31] Chen, Q., Song, H., Yu, J. and Kim, K. (2021) Current Development and Applications of Super-Resolution Ultrasound Imaging. Sensors, 21, Article 2417. [Google Scholar] [CrossRef] [PubMed]
[32] Chen, Q., Yu, J., Lukashova, L., Latoche, J.D., Zhu, J., Lavery, L., et al. (2020) Validation of Ultrasound Super-Resolution Imaging of Vasa Vasorum in Rabbit Atherosclerotic Plaques. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 67, 1725-1729. [Google Scholar] [CrossRef] [PubMed]
[33] Song, P., Rubin, J.M. and Lowerison, M.R. (2023) Super-Resolution Ultrasound Microvascular Imaging: Is It Ready for Clinical Use? Zeitschrift für Medizinische Physik, 33, 309-323. [Google Scholar] [CrossRef] [PubMed]
[34] 江珍珍, 刘夏天, 马彩叶, 侯传玲, 程祖胜, 夏国园. 白细胞介素18靶向超声微泡对动脉斑块分子成像的实验研究[J]. 中华危重症医学杂志, 2018, 11(2): 100-103.
[35] 刘金玲. 超声微泡造影应用于疾病诊疗的研究进展[J]. 中国中西医结合影像学杂志, 2010, 8(5): 453-455.
[36] 温伊林, 刘俐, 魏立亚, 等. 超声靶向微泡爆破技术诊治动脉粥样硬化的研究进展[J]. 中国心血管病研究, 2022, 20(8): 752-756.
[37] Wu, Y., Deng, C., Xu, J., Wang, W., Chen, Y., Qin, X., et al. (2023) Enhanced Local Delivery of MicroRNA-145a-5p into Mouse Aorta via Ultrasound-Targeted Microbubble Destruction Inhibits Atherosclerotic Plaque Formation. Molecular Pharmaceutics, 20, 1086-1095. [Google Scholar] [CrossRef] [PubMed]
[38] Yang, L., Chen, L., Fang, Y. and Ma, S. (2021) Downregulation of GSK-3β Expression via Ultrasound-Targeted Microbubble Destruction Enhances Atherosclerotic Plaque Stability in New Zealand Rabbits. Ultrasound in Medicine & Biology, 47, 710-722. [Google Scholar] [CrossRef] [PubMed]
[39] 黄鑫, 邓倾, 雷雨蒙, 田怡, 胡玉刚, 张瑶, 周青. 超声超分辨率成像评估前列腺结节微血管特征的可行性研究[J]. 中国超声医学杂志, 2025, 41(2): 206-209.
[40] 陈蝶, 陈红, 吴晶晶, 郑恩海, 关莹. 颈部血管超声、CT血管成像及磁共振血管造影诊断急性脑梗死患者颈动脉狭窄的研究[J]. 中国医学装备, 2023, 20(4): 52-55.
[41] Saba, L., Sanagala, S.S., Gupta, S.K., Koppula, V.K., Johri, A.M., Khanna, N.N., et al. (2021) Multimodality Carotid Plaque Tissue Characterization and Classification in the Artificial Intelligence Paradigm: A Narrative Review for Stroke Application. Annals of Translational Medicine, 9, Article 1206. [Google Scholar] [CrossRef] [PubMed]
[42] 杨振, 张明博, 罗渝昆. 超声分子靶向造影剂的应用研究进展[J]. 中国医学科学院学报, 2023, 45(2): 298-302.