转运体SLC26A6与草酸钙泌尿系结石的相互 作用及影响因素的研究进展
Research Progress on the Interaction between the Transporter SLC26A6 and Calcium Oxalate Urolithiasis and Its Influencing Factors
DOI: 10.12677/acm.2026.163922, PDF,    科研立项经费支持
作者: 梁晓涛, 雷自勇, 刘入铭, 方 玮, 陈禹希, 姜永明*:昆明医科大学第二附属医院泌尿外科,云南 昆明
关键词: 草酸钙结石SLC26A6泌尿系结石肠道菌群Calcium Oxalate Stone Transporter SLC26A6 Urinary System Stones Gut Microbiota
摘要: 泌尿系结石是我国最常见的泌尿外科疾病之一,在泌尿外科住院患者中占据首位,并且伴随着环境,饮食习惯等多种因素的影响,我国近年来的发病率正逐年上升。对于泌尿系结石,除了进一步开展更为有效的治疗方式,还应重视其预防手段的研究。转运体SLC26A6 (PAT1)与草酸钙类泌尿系结石存在重要联系。本篇综述通过分别阐述目前PAT1于肠道位点及肾脏近端小管位点对于草酸钙类结石的影响机制及其相关影响因素(包括肠道菌群及其代谢产物,雌激素等)的研究进展对预防草酸钙类泌尿系结石提出建议。
Abstract: Urolithiasis is one of the most common urological diseases in China and ranks first among hospitalized patients in urology. Influenced by various factors such as environment and dietary habits, the incidence rate in China has been gradually increasing in recent years. For urolithiasis, in addition to developing more effective treatments, attention should also be given to research on preventive measures. Several studies have indicated that the transporter SLC26A6 (PAT1) is closely associated with calcium oxalate urolithiasis. This review discusses the research progress on the mechanisms by which PAT1 affects calcium oxalate stones at the intestinal and renal proximal tubule sites, as well as related influencing factors (including gut microbiota and its metabolites, estrogen, etc.), and provides recommendations for the prevention of calcium oxalate urolithiasis.
文章引用:梁晓涛, 雷自勇, 刘入铭, 方玮, 陈禹希, 姜永明. 转运体SLC26A6与草酸钙泌尿系结石的相互 作用及影响因素的研究进展[J]. 临床医学进展, 2026, 16(3): 1422-1428. https://doi.org/10.12677/acm.2026.163922

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