安宫牛黄丸治疗CAR-T相关细胞因子释放 综合征

Treatment of CAR-T-Associated Cytokine Release Syndrome with Angong Niuhuang Pill

摘要: 安宫牛黄丸是中医经典急救用药，具有清热解毒、镇惊开窍的功效。嵌合抗原受体T (chimeric antigen receptor T, CAR-T)细胞治疗通过基因修饰T细胞使其能够靶向并杀伤异常细胞。CAR-T细胞治疗已成为恶性血液病治疗的重要手段。经过CAR-T细胞治疗，患者生存周期明显延长。CAR-T细胞治疗在为患者带来新的生机时刻，也带来了一系列副作用，常见的包括细胞因子释放综合征(Cytokine Release Syndrome, CRS)、免疫效应细胞相关的神经毒性(Immune effector cell-associated neurotoxicity syndrome, ICANS)、慢性移植物抗宿主病(GVHD)。本文介绍1例安宫牛黄丸治疗CAR-T相关细胞因子释放综合征。

Abstract: Angong Niuhuang Pill is a classic first-aid medicine in traditional Chinese medicine, with the effects of clearing away heat and detoxifying, calming convulsions and inducing resuscitation. Chimeric antigen receptor T (CAR-T) cell therapy modifies T cells genetically to enable them to target and kill abnormal cells. CAR-T cell therapy has become an important treatment for hematologic malignancies, and the survival cycle of patients has been significantly prolonged after receiving this therapy. While bringing new hope to patients, CAR-T cell therapy also causes a series of adverse effects, commonly including Cytokine Release Syndrome (CRS), Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS), and chronic Graft-Versus-Host Disease (GVHD). This article reports one case of Angong Niuhuang Pill in the treatment of CAR-T-associated cytokine release syndrome.