亚低温治疗在创伤性脑损伤中的应用进展
Advances in the Application of Hypothermia Therapy in Traumatic Brain Injury
DOI: 10.12677/acm.2026.163948, PDF,   
作者: 冉春艳：重庆市万州区上海医院重症医学科，重庆；赖烈勇*：重庆市万州区上海医院麻醉科，重庆
关键词: 创伤性脑损伤；亚低温治疗；Traumatic Brain Injury (TBI)； Hypothermic Therapy (HT)
摘要: 创伤性脑损伤(Traumatic Brain Injury, TBI)因其高发病率、高重症化率以及高致残率给社会带来沉重经济负担，因此改进其治疗手段一直是临床研究重点与热点。亚低温治疗(Hypothermic Therapy, HT)目前已经广泛应用于临床许多疾病的治疗；但HT在TBI的治疗中仍旧面临许多问题亟待解决。本文我们从Pubmed、Web of science、知网等平台根据关键词“创伤性脑损伤”、“亚低温治疗”、“创伤性脑损伤 + 亚低温治疗”搜索近5年文献，在去掉重复性文章、病例报告、初步报告(未经证实数据)等文献后筛选出274篇文献作为备选。然后我们邀请重庆市内具有临床教学资质的三级甲等综合医院重症医学科、神经学科主任医师各2名，这4名专家综合讨论评估后最终筛选出59篇文献。本文就HT在TBI治疗中的诸多问题做一综述，进一步明确其实际价值以及未来的研究方向。
Abstract: Traumatic Brain Injury (TBI) imposes a heavy economic burden on society due to its high incidence, high severity rate, and high disability rate. Therefore, improving its treatment methods has long been a key focus and research hotspot in clinical medicine. Hypothermic Therapy (HT) is currently widely used in the treatment of many clinical conditions; however, HT still faces numerous challenges in the management of TBI that require urgent resolution. In this study, we searched the literature from the past 5 years on platforms including PubMed, Web of Science, and CNKI using the keywords “Taumatic Brain Injury”, “Mild Hypothermia Therapy”, and “Traumatic Brain Injury + Mild Hypothermia Therapy”. After excluding duplicate articles, case reports, preliminary reports (with unconfirmed data), and other irrelevant literature, 274 articles were selected as candidates. We then invited 2 chief physicians from the Department of Critical Care Medicine and 2 chief physicians from the Department of Neurology, all from tertiary Class A general hospitals with clinical teaching qualifications in Chongqing, resulting in a total of 4 experts. Following comprehensive discussion and evaluation by these experts, 59 articles were ultimately included. This paper reviews several issues regarding HT in the treatment of TBI, to further clarify its practical value and future research directions.
文章引用：冉春艳, 赖烈勇. 亚低温治疗在创伤性脑损伤中的应用进展[J]. 临床医学进展, 2026, 16(3): 1636-1643. https://doi.org/10.12677/acm.2026.163948

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